scholarly journals Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage.

BMJ ◽  
1985 ◽  
Vol 291 (6493) ◽  
pp. 427-431 ◽  
Author(s):  
G J Beckett ◽  
H A Kellett ◽  
S M Gow ◽  
A J Hussey ◽  
J D Hayes ◽  
...  
1987 ◽  
Vol 169 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Geoffrey J. Beckett ◽  
Peter C. Hayes ◽  
Amanda J. Hussey ◽  
Ian A.D. Bouchier ◽  
John D. Hayes

1990 ◽  
Vol 9 (3) ◽  
pp. 183-186 ◽  
Author(s):  
G.J. Beckett ◽  
J.W. Donovan ◽  
A.J. Hussey ◽  
A.T. Proudfoot ◽  
L.F. Prescott

The concentration of glutatione S-transferase B1 (GST B1) subunits was measured in sequential plasma samples taken at frequent intervals for 48 h from ten patients with severe paracetamol poisoning who were treated with intravenous N-acetylcysteine. No significant increase in plasma GST B1 concentration was observed over the study period and within 4 h of starting treatment with N-acetylcysteine there were significant decreases in plasma GST B1 concentrations. None of the patients subsequently developed significant liver damage. At the dose used for the treatment of paracetamol poisoning, N-acetylcysteine has no hepatotoxic effects.


2013 ◽  
pp. 65-71 ◽  
Author(s):  
Mitsuru Ito ◽  
Akira Kitanaka ◽  
Takeshi Arishima ◽  
Takumi Kudo ◽  
Eijun Nishihara ◽  
...  

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