scholarly journals Ear, nose, and throat symptoms in subacute Wegener's granulomatosis.

BMJ ◽  
1989 ◽  
Vol 299 (6702) ◽  
pp. 791-791
2012 ◽  
Vol 63 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Carmelo Morales-Angulo ◽  
Roberto García-Zornoza ◽  
Sergio Obeso-Agüera ◽  
Jaime Calvo-Alén ◽  
Miguel A. González-Gay

BMJ ◽  
1989 ◽  
Vol 299 (6702) ◽  
pp. 791-791 ◽  
Author(s):  
G. E Murty ◽  
B. T Mains

BMJ ◽  
1989 ◽  
Vol 299 (6696) ◽  
pp. 419-422 ◽  
Author(s):  
D. P. D'Cruz ◽  
E. Baguley ◽  
R. A. Asherson ◽  
G. R. Hughes

Author(s):  
Marlies Böhm ◽  
Sandra Basson

Granulomatosis with polyangiitis (Wegener’s granulomatosis) is one of the idiopathicimmune-mediated small-vessel vasculitides described in humans which are characterised bythe presence of circulating antineutrophil cytoplasmic antibodies. It most commonly involvescapillaries, venules and arterioles of the ear, nose and throat, lungs and glomeruli. A caseof destructive haemopurulent rhinitis associated with relapsing periods of pyrexia, lethargyand stiffness as well as generalised pulmonary infiltrates in a young Anatolian shepherddog is presented that closely resembles granulomatosis with polyangiitis (GPA) as reportedin humans. Perinuclear antineutrophil cytoplasmic antibodies (pANCA) were detectedin the dog’s serum. Signs resolved promptly and completely once immunosuppressivedoses of prednisone were administered, and have not recurred. This is the first report onthe use of pANCA to investigate rhinitis in dogs. It is also, to the authors’ knowledge,the first description of a relapsing haemopurulent lytic rhinitis in this species. Theconcurrent manifestations of erosive haemopurulent rhinitis, ground-glass opacities onpulmonary computed tomography, pyrexia and listlessness resemble GPA as described inhumans.


2005 ◽  
Vol 16 (08) ◽  
pp. 596-599
Author(s):  
Raymond H. Hull

This case report of bilateral otitis media in a 39-year-old woman secondary to Wegener's Granulomatosis highlights, for the audiologist, the importance of being aware of some of the less common etiologies of middle ear disease. Bilateral otitis media that resists usual forms of medical treatment may represent one of the earliest signs of Wegener's Granulomatosis, a potentially life-threatening disease. According to recent literature, involvement of the ears, nose, and throat can in many instances be the only early manifestation of the disease. It is important that audiologists be aware of the early signs in order to make appropriate referral for treatment, particularly since they are usually among the first to see these patients. Early diagnosis and referral is critical since the mean survival of untreated WG is five months, with 82% of patients dying within one year, and more than 90% dying within two years. The disease involves a systemic vasculitis that may involve any organ system: however, pulmonary or renal disease appear to be among the later signs, while both middle ear and upper respiratory involvement are frequently among the earliest.


BMJ ◽  
1989 ◽  
Vol 299 (6702) ◽  
pp. 791-791 ◽  
Author(s):  
R. Vaughan-Jones ◽  
N. Padgham

BMJ ◽  
1989 ◽  
Vol 299 (6705) ◽  
pp. 975-975
Author(s):  
G R V Hughes ◽  
D D'Cruz ◽  
R Asherson ◽  
E Baguley

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