scholarly journals The response to prednisolone in atrophic gastritis: a possible effect on non-intrinsic factor-mediated vitamin B12 absorption

Gut ◽  
1973 ◽  
Vol 14 (1) ◽  
pp. 13-19 ◽  
Author(s):  
R. G. Strickland ◽  
J. M. Fisher ◽  
K. Lewin ◽  
K. B. Taylor
Keyword(s):  
Vitamin B12 ◽  
Atrophic Gastritis ◽  
Intrinsic Factor ◽  
Vitamin B12 Absorption

scholarly journals Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
G. F. Cittolin-Santos ◽  
S. Khalil ◽  
J. K. Bakos ◽  
K. Baker
Keyword(s):  
Vitamin B12 ◽  
Atrophic Gastritis ◽  
Pernicious Anemia ◽  
Hemolytic Anemia ◽  
Parietal Cell ◽  
Intrinsic Factor ◽  
Peripheral Blood Smear ◽  
Chronic Atrophic Gastritis ◽  
Cell Antibody ◽  
Parietal Cell Antibody

A 28-year-old Caucasian male with Hashimoto’s disease and vitiligo presented with two weeks of dizziness on exertion following pharyngitis which was treated with prednisone 40 mg by mouth once a day for five days. Initial workup revealed anemia, elevated lactate dehydrogenase (LDH), and low haptoglobin. He underwent workup for causes of hemolytic anemia which was remarkable for a peripheral blood smear with hypersegmented neutrophils and low vitamin B12 levels concerning for pernicious anemia. Parietal cell and intrinsic factor antibodies were negative, and he then underwent an esophagogastroduodenoscopy with biopsy. The biopsy was negative for Helicobacter pylori, and the immunohistochemical stains were suggestive of chronic atrophic gastritis. He was started on vitamin B12 1,000 mcg intramuscular injections daily. His hemoglobin, LDH, and haptoglobin normalized. Given the absence of the parietal cell antibody and intrinsic factor antibody, this is a rare case of seronegative pernicious anemia.

scholarly journals Vitamin B12 Malabsorption Due to Intrinsic Factor Deficiency in Indian Subjects

Blood ◽  
1972 ◽  
Vol 40 (5) ◽  
pp. 747-753 ◽  
Author(s):  
H. G. Desai ◽  
F. P. Antia
Keyword(s):  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Indian Population ◽  
Intrinsic Factor ◽  
Subacute Combined Degeneration ◽  
Factor Deficiency ◽  
Vitamin B12 Absorption ◽  
Intrinsic Factor Deficiency ◽  
Intrinsic Factor Antibody ◽  
Vitamin B12 Malabsorption

Abstract Sixteen patients (from Bombay) with severe vitamin B12 malabsorption due to intrinsic factor deficiency, presenting as subacute combined degeneration of the cord (7), tropical sprue (3), anemia (2), thyrotoxicosis (2), diabetes mellitus (1), and pain in the abdomen (1), are reported. The difficulties of establishing a definite diagnosis of pernicious anemia in Indian population are described. The lower incidence of circulating intrinsic factor antibody (IFA) in Indian patients with histamine-fast achlorhydria and poor vitamin B12 absorption is emphasized. The necessity of separating atrophic gastritis, with severely impaired vitamm B12 absorption, from pernicious anemia on the basis of absence or presence of IFA in serum and/or gastric juice cannot be overemphasized.

Intestinal distribution of intrinsic factor and vitamin B12 absorption

1965 ◽  
Vol 208 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Kunio Okuda ◽  
Katsumi Sasayama
Keyword(s):  
Small Intestine ◽  
Vitamin B12 ◽  
Large Intestine ◽  
Intrinsic Factor ◽  
Vitamin B ◽  
Vitamin B12 Absorption ◽  
Small Intestine Absorption

Evidence is presented that intrinsic-factor (IF) activity is present in the small intestine as far down as the ileal end. Physiologic doses of radioactive vitamin B12 without IF were applied directly into various levels of the intestine by surgical and other means in man and rats, and significant absorption was obtained from the small intestine. Absorption inhibition by ethylenediaminetetraacetate and its counteraction by Ca ion demonstrated that such absorption was dependent on IF action. The large intestine was shown to be incapable of physiologic absorption of vitamin B12, and IF was totally ineffective. It is proposed that physiologically, gastric IF descends with some activity in the small intestine, where more of the food vitamin B12 is liberated by digestion and subjected to IF.

Effect of Rat Intrinsic Factor on Vitamin B12 Absorption in Pernicious Anemia

Science ◽  
1957 ◽  
Vol 126 (3273) ◽  
pp. 558-558 ◽  
Author(s):  
J. ABELS ◽  
M. G. WOLDRING ◽  
J. J. M. VEGTER ◽  
H. O. NIEWEG
Keyword(s):  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Intrinsic Factor ◽  
Vitamin B12 Absorption

scholarly journals Total Body Counting in the Assessment of Vitamin B12 Absorption in Patients with Pernicious Anemia, Achlorhydria Without Pernicious Anemia and in Acid Secretors

Blood ◽  
1970 ◽  
Vol 36 (1) ◽  
pp. 20-27 ◽  
Author(s):  
W. J. IRVINE ◽  
D. R. CULLEN ◽  
LAURA SCARTH ◽  
J. D. SIMPSON ◽  
S. H. DAVIES
Keyword(s):  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Intrinsic Factor ◽  
Body Counting ◽  
Acid Secreting ◽  
Vitamin B12 Absorption ◽  
Upper Level ◽  
Equivocal Result ◽  
Total Body ◽  
Cent Error

Abstract The absorption of 58Co-vitamin B12 was assessed by the method of total body counting in 25 patients with frank P.A., five with latent P.A., 47 with achlorhydria but without malabsorption of vitamin B12 and 47 acid-secreting patients. A total of 192 tests was done. With or without prior stimulation of intrinsic factor secretion by pentagastrin the upper level of absorption of vitamin B12 in patients with frank or latent P.A. was 25 per cent. Taking an equivocal result to be 21-25 per cent inclusive, the total body counting method was able to distinguish P.A. patients from those with achlorhydria without P.A. with 87 per cent accuracy and one per cent error and from non-P.A. achlorhydric patients and acid secretors combined with 91 per cent accuracy and 0.5 per cent error. Pentagastrin stimulation did not improve the separation between achlorhydric patients with and without P.A. but raised the lower limit of retention of vitamin B12 from 24 to 44 per cent in the acid secreting patients. The method of total body counting is recommended as a method of assessing vitamin B12 absorption.

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