scholarly journals PTU-131 Prevalence Of Abnormal Liver Functions Tests (lfts) In Obstructive Sleep Apnea (osa) Patients And Change In Lfts After Continuous Positive Airway Pressure (cpap) Therapy

Gut ◽  
2014 ◽  
Vol 63 (Suppl 1) ◽  
pp. A96.2-A96 ◽  
Author(s):  
R Haider ◽  
HJ O’Connor ◽  
M Azam
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Cpap Therapy ◽  
Obstructive Sleep ◽  
Liver Functions

scholarly journals The Effect of Continuous Positive Airway Pressure Therapy on Obstructive Sleep Apnea-Related Hypertension

2021 ◽  
Vol 22 (5) ◽  
pp. 2300
Author(s):  
Ronni Baran ◽  
Daniela Grimm ◽  
Manfred Infanger ◽  
Markus Wehland
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Common Disease ◽  
Cpap Therapy ◽  
Pressure Therapy ◽  
Airway Patency ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) is a common disease, with approximately 3–7% of men and 2–5% of women worldwide suffering from symptomatic OSA. If OSA is left untreated, hypoxia, microarousals and increased chemoreceptor stimulation can lead to complications like hypertension (HT). Continuous positive airway pressure (CPAP) is the most common treatment for OSA, and it works by generating airway patency, which will counteract the apnea or hypopnea. More than one billion people in the world suffer from HT, and the usual treatment is pharmacological with antihypertensive medication (AHM). The focus of this review will be to investigate whether the CPAP therapy for OSA affects HT.

Effect of continuous positive airway pressure (CPAP) therapy on IL-23 in patients with obstructive sleep apnea

2016 ◽  
Vol 64 (5-6) ◽  
pp. 1179-1184 ◽  
Author(s):  
Murat Can ◽  
Fırat Uygur ◽  
Hakan Tanrıverdi ◽  
Bilgehan Acıkgoz ◽  
Barıs Alper ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Cpap Therapy ◽  
Obstructive Sleep

scholarly journals Continuous positive airway pressure treatment does not normalize the prolonged reflex inhibition to inspiratory loading in obstructive sleep apnea

2016 ◽  
Vol 121 (4) ◽  
pp. 910-916
Author(s):  
Nicholas P. S. Murray ◽  
David K. McKenzie ◽  
Simon C. Gandevia ◽  
Jane E. Butler
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Obstruction ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Upper Airway ◽  
Cpap Therapy ◽  
Airway Occlusion ◽  
Obstructive Sleep

In obstructive sleep apnea (OSA), the short-latency inhibitory reflex (IR) of inspiratory muscles to airway occlusion is prolonged in proportion to the severity of the OSA. The mechanism underlying the prolongation may relate to chronic inspiratory muscle loading due to upper airway obstruction or sensory changes due to chronic OSA-mediated inflammation. Continuous positive airway pressure (CPAP) therapy prevents upper airway obstruction and reverses inflammation. We therefore tested whether CPAP therapy normalized the IR abnormality in OSA. The IR responses of scalene muscles to brief airway occlusion were measured in 37 adult participants with untreated, mostly severe, OSA, of whom 13 were restudied after the initiation of CPAP therapy (usage >4 h/night). Participants received CPAP treatment as standard clinical care, and the mean CPAP usage between initial and subsequent studies was 6.5 h/night (range 4.1-8.8 h/night) for a mean of 19 mo (range 4–41 mo). The duration of the IR in scalene muscles in response to brief (250 ms) inspiratory loading was confirmed to be prolonged in the participants with OSA. The IR was assessed before and after CPAP therapy. CPAP treatment did not normalize the prolonged duration of the IR to airway occlusion (60 ± 21 ms pretreatment vs. 59 ± 18 ms posttreatment, means ± SD) observed in participants with severe OSA. This suggests that the prolongation of IR reflects alterations in the reflex pathway that may be irreversible, or a specific disease trait.

scholarly journals Quantitative Changes in Muscular and Capillary Oxygen Desaturation Measured by Optical Sensors during Continuous Positive Airway Pressure Titration for Obstructive Sleep Apnea

Biosensors ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 3
Author(s):  
Zhongxing Zhang ◽  
Ming Qi ◽  
Gordana Hügli ◽  
Ramin Khatami
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Optical Sensors ◽  
Pulse Oximeter ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Real Life ◽  
Cpap Therapy ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) is a common sleep disorder, and continuous positive airway pressure (CPAP) is the most effective treatment. Poor adherence is one of the major challenges in CPAP therapy. The recent boom of wearable optical sensors measuring oxygen saturation makes at-home multiple-night CPAP titrations possible, which may essentially improve the adherence of CPAP therapy by optimizing its pressure in a real-life setting economically. We tested whether the oxygen desaturations (ODs) measured in the arm muscle (arm_OD) by gold-standard frequency-domain multi-distance near-infrared spectroscopy (FDMD-NIRS) change quantitatively with titrated CPAP pressures in OSA patients together with polysomnography. We found that the arm_OD (2.08 ± 1.23%, mean ± standard deviation) was significantly smaller (p-value < 0.0001) than the fingertip OD (finger_OD) (4.46 ± 2.37%) measured by a polysomnography pulse oximeter. Linear mixed-effects models suggested that CPAP pressure was a significant predictor for finger_OD but not for arm_OD. Since FDMD-NIRS measures a mixture of arterial and venous OD, whereas a fingertip pulse oximeter measures arterial OD, our results of no association between arm_OD and finger_OD indicate that the arm_OD mainly represented venous desaturation. Arm_OD measured by optical sensors used for wearables may not be a suitable indicator of the CPAP titration effectiveness.

scholarly journals Effectiveness of structured educational programs in increasing adherence to CPAP therapy in patients with obstructive sleep apnea/hypopnea syndrome

2016 ◽  
Vol 97 (4) ◽  
pp. 535-540
Author(s):  
A K Myrzaakhmatova ◽  
T M Sooronbaev
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Educational Program ◽  
Positive Airway Pressure ◽  
Cpap Therapy ◽  
Obstructive Sleep ◽  
The Creation ◽  
Hypopnea Syndrome

Aim. To study the effectiveness of a structured educational program in improving adherence to therapy with the creation of continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea/hypopnea syndrome.Methods. The study included 40 patients with moderate to severe obstructive sleep apnea/hypopnea syndrome, who received CPAP therapy. Patients were divided into two groups: the first group (main) - 20 patients who had undergone training according to a specially designed structured educational program, the second group (control) - 20 patients who had not received training. CPAP therapy was considered as effective in case of reducing the apnea-hypopnea index to less than 5 per hour of sleep, with an average duration of the machine use for the night was to be more than 5 hours.Results. Using a structured educational program in patients of the main (first) group showed a good adherence of patients and the effectiveness of CPAP therapy. Positive dynamics of clinical symptoms, in particular a decrease in daytime sleepiness, assessed according to Epworth sleepiness scale (17.1±4.2 vs. 3.9±1.6; p=0,0000), was registered, the number of pauses in breathing during the night significantly reduced (44.37±14.6 vs. 2.86±3.5 per hour; p=0,0000), accompanied by improvement of night saturation parameters: SpO2min (58.4±9.0 vs. 78.0±9.3; p=0,0000), SpO2mean (87.2±6.8 vs. 93.1±3.5; p=0,0018). Against this background, after 3 months of therapy a decrease in body mass index and blood pressure was registered.Conclusion. The implementation of a structured educational program showed increase in adherence and the effectiveness of therapy with the creation of continuous positive airway pressure (CPAP therapy) in treating obstructive sleep apnea/hypopnea syndrome.

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