Objective: To evaluate early changes in left ventricular systolic
function in patients with systemic lupus erythematosus (SLE) using
three-dimensional speckle tracking imaging (3D-STI). Methods: Thirty SLE
patients and 30 healthy people (control group) were selected, the
patients were further divided into subgroups according to their Safety
of Estrogens in Lupus Erythematosus National Assessment version of the
SLE Disease Activity Index (SELENA-SLEDAI) score: SELENA-SLEDAI ≤ 12
(mild-to-moderate group), SELENA-SLEDAI > 12 (severe
group). Blood samples were obtained from patients and laboratory
investigations were performed. All participants were examined using
3D-STI, the 3D conventional and strain parameters were obtained. The
above parameters were compared in the three studied groups. Receiver
operating curves (ROC) were prepared for above parameters and analyzed
to identify correlations among LVEF, GLS, GCS, LVtw, Tor, MCI and
hs-TropT. Results: Compared with the control group, the absolute values
of LVEDV, LVEF, GLS, GCS, LVtw, Tor and MCI decreased, LV EDmass, LV
ESmass and PSD increased in the mild-to-moderate and the severe groups
(P2 < 0.05, P3 < 0.05). There was statistically
significant difference in terms of strain parameters between the
mild-to-moderate group and the severe group (P1 < 0.05). The
highest area under the ROC for MCI was 0.909, the highest sensitivity
for MCI was 90.00%, and the highest specificity for Tor was 86.67%.
Correlation analysis showed that there was a good correlation between
the MCI and hs-TropT (r = − 0.677). Conclusion: 3D-STI technology may
help detect early changes in left ventricular systolic function in
patients with SLE
ASSESSMENT OF LEFT VENTRICULAR SYSTOLIC FUNCTION IN PATIENTS WITH MULTI-VESSEL CORONARY ARTERY DISEASE AND NORMAL WALL MOTION BY TWO-DIMENSIONAL SPECKLE TRACKING IMAGING
