Speckle tracking imaging combined with myocardial comprehensive index to evaluate left ventricular function changes in patients with systemic lupus erythematosus

Objective: To evaluate early changes in left ventricular systolic function in patients with systemic lupus erythematosus (SLE) using three-dimensional speckle tracking imaging (3D-STI). Methods: Thirty SLE patients and 30 healthy people (control group) were selected, the patients were further divided into subgroups according to their Safety of Estrogens in Lupus Erythematosus National Assessment version of the SLE Disease Activity Index (SELENA-SLEDAI) score: SELENA-SLEDAI ≤ 12 (mild-to-moderate group), SELENA-SLEDAI > 12 (severe group). Blood samples were obtained from patients and laboratory investigations were performed. All participants were examined using 3D-STI, the 3D conventional and strain parameters were obtained. The above parameters were compared in the three studied groups. Receiver operating curves (ROC) were prepared for above parameters and analyzed to identify correlations among LVEF, GLS, GCS, LVtw, Tor, MCI and hs-TropT. Results: Compared with the control group, the absolute values of LVEDV, LVEF, GLS, GCS, LVtw, Tor and MCI decreased, LV EDmass, LV ESmass and PSD increased in the mild-to-moderate and the severe groups (P2 < 0.05, P3 < 0.05). There was statistically significant difference in terms of strain parameters between the mild-to-moderate group and the severe group (P1 < 0.05). The highest area under the ROC for MCI was 0.909, the highest sensitivity for MCI was 90.00%, and the highest specificity for Tor was 86.67%. Correlation analysis showed that there was a good correlation between the MCI and hs-TropT (r = − 0.677). Conclusion: 3D-STI technology may help detect early changes in left ventricular systolic function in patients with SLE

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Speckle Tracking Imaging Combined With Myocardial Comprehensive Index to Evaluate Left Ventricular Function Changes in Patients With Systemic Lupus Erythematosus

10.21203/rs.3.rs-167252/v1 ◽

2021 ◽

Author(s):

Jia Feng ◽

zijing Zhai ◽

zhen Wang ◽

lei Huang ◽

shanshan Dong ◽

...

Keyword(s):

Lupus Erythematosus ◽

Speckle Tracking ◽

Systolic Function ◽

Left Ventricular Systolic Function ◽

Left Ventricular ◽

Control Group ◽

Speckle Tracking Imaging ◽

Systemic Lupus ◽

Ventricular Systolic Function ◽

Comprehensive Index

Abstract ObjectiveTo evaluate left ventricular systolic function in patients with systemic lupus erythematosus (SLE) using three-dimensional speckle tracking imaging (3D-STI). MethodsThirty patients with SLE (SLE group) and 30 healthy people (control group) were examined using 3D-STI, and their clinical characteristics were collected. The following conventional 3D parameters were obtained: left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), spherical index (SPI), left ventricular end-diastolic mass (LV EDmass), and left ventricular end-systolic mass (LV ESmass). The following 3D-STI strain parameters were obtained: global longitudinal strain (GLS), global circumferential strain (GCS), left ventricular twist angle (LVtw), torque (Tor), peak strain dispersion (PSD), and myocardial comprehensive index (MCI). Statistical analysis was used to analyze the differences in the above indicators among the groups and their correlations. ResultsLVEDV and LVEF decreased; LV EDmass and LV ESmass increased; GLS, GCS, LVtw, Tor, and MCI decreased; and PSD increased in the SLE group compared with the control group (P < 0.05). The receiver operating characteristic curve showed that the area under the curve of the MCI was the highest (0.940), the sensitivity of the Tor and MCI was the highest (90.00%), and the specificity of the Tor was the highest (93.33%). Correlation analysis showed that there was a good correlation between the MCI and hs-TropT. ConclusionThe systolic function of the left ventricle is decreased in patients with SLE. 3D-STI technology can detect abnormal left ventricular systolic function in patients with SLE in the early stage.

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ASSESSMENT OF LEFT VENTRICULAR SYSTOLIC FUNCTION IN PATIENTS WITH MULTI-VESSEL CORONARY ARTERY DISEASE AND NORMAL WALL MOTION BY TWO-DIMENSIONAL SPECKLE TRACKING IMAGING

Heart ◽

10.1136/heartjnl-2012-302920ad.13 ◽

2012 ◽

Vol 98 (Suppl 2) ◽

pp. E295.1-E295

Author(s):

Manying Xie ◽

Qing Lu

Keyword(s):

Speckle Tracking ◽

Wall Motion ◽

Systolic Function ◽

Left Ventricular Systolic Function ◽

Left Ventricular ◽

Speckle Tracking Imaging ◽

Ventricular Systolic Function ◽

Normal Wall ◽

Artery Disease ◽

Vessel Coronary Artery

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Evaluation of left ventricular systolic function in patients with different types of ischemic heart disease by two-dimensional speckle tracking imaging

Journal of Cardiothoracic Surgery ◽

10.1186/s13019-020-01345-2 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Xing Xing ◽

Dan Li ◽

Shaomin Chen ◽

Lingli Wang ◽

Zhaoping Li ◽

...

Keyword(s):

Systolic Function ◽

Left Ventricular Systolic Function ◽

Left Ventricular ◽

Structure And Function ◽

Control Group ◽

Speckle Tracking Imaging ◽

Ventricular Systolic Function ◽

Different Types ◽

And Function ◽

Conventional Echocardiography

Abstract Background The purpose of this study was to evaluate left ventricular systolic function in patients with different types of ischemic heart disease using two-dimensional speckle tracking imaging (2D-STI). Methods We retrospectively studied patients who were admitted to Peking University Third Hospital from January 2011 to December 2017 due to chest tightness and chest pain. Two hundred forty-two patients were divided into control group, CMD group and obstructive CAD group. The main coronary artery stenosis was confirmed by coronary angiography or coronary computed tomography and coronary flow reserve (CFR) in patients was measured by transthoracic Doppler echocardiography. Left ventricular strain and strain rate (SR) measured by 2D-STI. Cardiac structure and function were measured by conventional echocardiography. Results Conventional echocardiography showed that there was no significant difference in cardiac structure and function among the three groups (P > 0.05). Moreover, the longitudinal strain (LS) of each ventricular wall in CMD group was notably lower than that in control group (P < 0.01). In addition, global longitudinal SR and longitudinal SR in CMD group and obstructive CAD group were obviously lower than those in control group (P < 0.01). GLS, endocardial LS and epicardial LS were negatively correlated with CFR (P < 0.01). Conclusions Early left ventricular systolic dysfunction was found in patients with CMD and patients with obstructive CAD, with similar degree. CFR is an independent influencing factor of GLS. GLS and stratified LS have certain diagnostic value for CMD.

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