Sentinel node detection in a patient with recurrent endometrial cancer initially treated by hysterectomy and radiotherapy

2004 ◽  
Vol 14 (4) ◽  
pp. 673-676 ◽  
Author(s):  
P. Van Dam ◽  
H. Sonnemans ◽  
P.-J. Van Dam ◽  
D. Smet ◽  
L. Verkinderen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Sentinel Node ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Pelvic Lymphadenectomy ◽  
Sentinel Node Detection ◽  
Lymph Node Sampling ◽  
Sentinel Node Identification ◽  
Grade Ii ◽  
The Right

This is the first article reporting sentinel node identification in a patient with endometrial cancer recurring in the vagina. A 79-year-old woman presented with a midvaginal recurrence of a stage IB, grade II endometroid carcinoma that had been treated 3 years earlier by a total abdominal hysterectomy, bilateral salpingoophorectomy, and pelvic lymph node sampling, followed by adjuvant brachytherapy to the vaginal vault. A staging examination under anesthetic was performed. Preoperatively, 60-MBq technetium-labeled nannocolloid was injected in the mucosa at 3, 6, 9, and 12 o'clock just adjacent to the tumor recurrence. Three sentinel nodes were detected, respectively, in the left obturator fossa (two) and the right external iliac region, using a laparoscopic probe (Navigator) and removed for pathological assessment. As they proved to be negative, the patient underwent a total vaginectomy, parametrectomy with pelvic lymphadenectomy. The tumor was completely removed, and all lymph nodes proved to be negative. The accuracy of sentinel node identification in patients with recurrent gynecological tumors needs further evaluation. This unique case shows that sentinel node detection is possible after previous radiotherapy and surgery and hopes to stimulate further research in this field.

Preliminary Study of Sentinel Node Identification with 99mTc Colloid and Blue Dye in Patients with Endometrial Cancer

2002 ◽  
Vol 88 (3) ◽  
pp. S9-S10 ◽  
Author(s):  
E Pelosi ◽  
V Arena ◽  
B Baudino ◽  
M Bellò ◽  
T Gargiulo ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Nodes ◽  
Sentinel Node ◽  
Histological Analysis ◽  
Early Stage ◽  
Figo Stage ◽  
Iliac Vein ◽  
Pelvic Lymphadenectomy ◽  
Blue Dye ◽  
Sentinel Node Identification

Aims and Background Intraoperative lymphatic mapping and sentinel node (SLN) biopsy have generated a tremendous amount of interest and are already established as part of the standard practice in the surgical management of breast cancer and melanoma. To reduce extensive radical procedures and decrease the morbidity in the treatment of gynecologic malignancies, much effort is being made to use less aggressive interventions. The purpose of our study was to determine the feasibility of SLN mapping in a group of patients with endometrial cancer at early stages. Method and study design Between September 2000 and May 2001 11 patients with endometrial cancer FIGO stage Ib (n = 10) and Ha (n = 1) underwent laparoscopic SLN detection during laparoscopy-assisted vaginal hysterectomy with bilateral salpingo-oophorectomy and bilateral systematic pelvic lymphadenectomy. Radioactive isotope injection was performed 24 hours before surgery and blue dye injection was performed just before surgery in the cervix at 3, 6, 9 and 12 hours. A 350 mm laparoscopic gamma scintyprobe MR 100 type 11, 99mTc settled (Pol Hi Tech), was used intraoperatively for SLN detection. Results Seventeen (17) SLNs were detected with lymphoscintigraphy (six bilateral and five unilateral). At laparoscopic surgery we found the same locations belonging at internal iliac lymph nodes (the so-called Lebeuf-Godard area, lateral to the inferior vesical artery, ventral to the origin of the uterine artery and medial or caudal to the external iliac vein). Fourteen (14) SLNs were negative on histological analysis and three were positive for micrometastases (mean SLN sections = 60). All other pelvic lymph nodes were negative at histological analysis. The same SLN locations detected with the gamma scintyprobe were observed at laparoscopy after patent blue dye injection. Conclusions Our preliminary data suggest that combined 99mTc-labeled colloid and vital blue-dye techniques are feasible for SLN detection in endometrial cancer; they represent a very promising tool to transform the management of early-stage endometrial cancer. The clinical validity of this combined technique should be evaluated prospectively.

scholarly journals Evaluation of clinical outcome of laparoscopic hysterectomy versus open abdominal hysterectomy with pelvic lymphadenectomy in endometrial carcinoma early stage

2021 ◽  
Vol 10 (6) ◽  
pp. 2203
Author(s):  
Waleed M. Tawfik ◽  
Wagdy M. Amer ◽  
Ahmed F. Sherif
Keyword(s):  
Endometrial Cancer ◽  
Blood Loss ◽  
Hospital Stay ◽  
Early Stage ◽  
Clinical Stage ◽  
Laparoscopic Hysterectomy ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Pelvic Lymphadenectomy ◽  
The Mean

Background: the aim of this study was to compare the operative, post-operative, and the oncological short-term outcomes of laparoscopic hysterectomy with lymphadenectomy and open abdominal hysterectomy with lymphadenectomy for early-stage endometrial cancer.Methods: 80 patients with clinical stage I endometrial cancer were enrolled in this trial; they were divided according to their selection of the method of intervention after counselling into two groups: total laparoscopic hysterectomy with pelvic lymphadenectomy group and total abdominal hysterectomy with pelvic lymphadenectomy group.Results: The mean operative time in the TLH group was 140.85± 10.033 minutes and was 118.45±12.713 minutes in the TAH group (p<0.001). The mean blood loss in the TLH group was 127.5±42.9 ml and 220.5± 84.82 ml in TAH group (p<0.001). The mean duration of postoperative ileus was 12.8±5.022 hours in the TLH group, and it was 22.3±5.573 hours in the TAH group (p<0.001). The mean time of hospital stay in the TLH group was 26.7±5.667 hours and in the TAH group was 116.4± 17.31 hours (p<0.001).Conclusions: Complete surgical staging of endometrial cancer can be performed using laparoscopy as an alternative to routine open method with similar efficacy about nodal retrieval and complication rate, and better operative and postoperative compliance in means of blood loss, ileus and hospital stay which may have an implication on cost saving in the medical service. Lymphadenectomy can be omitted in low-risk cases of endometrial cancer.

Surgical procedures

2017 ◽  
Keyword(s):  
Hip Replacement ◽  
Reading Time ◽  
Clinical Skills ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Safety Communication ◽  
Safety Issues ◽  
Problem Solve ◽  
The Right ◽  
Initial Reading

This task assesses the following clinical skills: … ● Patient safety ● Communication with colleagues ● Applied clinical knowledge … Mrs. Ahmed is a 48- year- old lady undergoing total abdominal hysterectomy and bilateral salpingo-oophorectomy for heavy menstrual bleeding with a 20 week size fibroid. She is generally well and has undergone a left hip replacement five years ago. Your consultant has asked you to commence the surgery by opening the abdomen with a vertical subumbilical incision. She will shortly join you for the surgery. The Foundation Year 1 doctor will be assisting you in the interim. You will be presented with scenarios in the theatre. Your task is to problem solve and answer the queries of the F1 doctor. You have 10 minutes for this task (+ 2mins initial reading time). There is no role player for this scenario. This scenario checks the understanding of Monopolar diathermy and the ability to problem solve. It also assesses the understanding of safety issues surrounding electrocautery. First tell the candidate: The Theatre Assistant Practitioner (ODP) is newly qualified and normally works in the ENT theatres. You start the incision using a finger switch diathermy but it is not working What will you do? The candidate should first check if the machine is on Tell them that is was not on, but has now been switched on As soon as the machine is switched on, the machine starts beeping What should the ODP do next? If the candidate asks if there are any indications on the machine, say the sign of the returning electrodes is highlighted The candidate should check if the returning electrodes (pads) have been applied. They had not been. The ODP asks where he should apply the returning electrodes. The candidates should ask the electrode to be placed on the right buttock. The ODP asks if it is OK to put the returning electrode on the left buttock as the scrub nurse and trolley are on the right and it is convenient to apply on the left. The candidate should explain that as Mrs. Ahmed has had a hip replacement on the left, it is important to avoid applying the returning electrode near the metal implant and the scarring around it, for safety. The ODP asks that he has never seen a split returning electrode. Why is it split?

Laparoscopically assisted vaginal hysterectomy versus abdominal hysterectomy in stage I endometrial cancer

2002 ◽  
Vol 12 (1) ◽  
pp. 57-61 ◽  
Author(s):  
K. M Fram
Keyword(s):  
Endometrial Cancer ◽  
Postoperative Complications ◽  
Blood Loss ◽  
Vaginal Hysterectomy ◽  
Intraoperative Complications ◽  
Abdominal Hysterectomy ◽  
Pelvic Lymphadenectomy ◽  
Stage I ◽  
Laparoscopic Treatment ◽  
Laparoscopically Assisted Vaginal Hysterectomy

Abstract.Fram KM. Laparoscopically assisted vaginal hysterectomy versus abdominal hysterectomy in stage I endometrial cancer.The purpose of this study was to evaluate and compare laparoscopic treatment for stage I endometrial cancer with the traditional transabdominal approach. From July 1996 to July 1998, 61 patients with clinical stage I endometrial cancer were treated at the Gynaecology Oncology Unit at the Royal North Shore of Sydney, Australia. Twenty-nine patients were treated with laparoscopic assisted vaginal hysterectomy (LAVH) and bilateral salpingo-oophrectomy (BSO) ± laparoscopic pelvic lymphadenectomy (LPLA), while 32 patients were treated with the traditional laparotomy and underwent total abdominal hysterectomy (TAH) and BSO ± pelvic lymphadenectomy (PLA). The main outcomes studied were operative time, blood loss, blood transfusion, intraoperative complications, postoperative complications, duration of hospital stay, and number of lymph nodes obtained. In conclusion, laparoscopic treatment of endometrial cancer is safe in the hands of experienced operators with minimal intraoperative and postoperative complications. This procedure is associated with significantly less blood loss and shorter hospitalization; however, it is associated with significantly longer operating time. Proper selection of patients for the laparoscopic procedure is the vital step in achieving the major goals of this approach.

Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 379-384
Author(s):  
A. Karateke ◽  
A. Gurbuz ◽  
G. Kir ◽  
B. Haliloglu ◽  
C. Kabaca ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Dermoid Cyst ◽  
Adenosquamous Carcinoma ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Review Of The Literature ◽  
Lymph Node Sampling ◽  
Aortic Lymph Node ◽  
Ovarian Dermoid Cyst

A 40-year-old woman with mucoepidermoid variant of adenosquamous carcinoma arising in dermoid cyst in left ovary is presented. The patient was staged as IC. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and pelvic and para-aortic lymph node sampling were carried out. The disease recurred in postoperative 12th month. To our best knowledge, this is 12th case of adenosquamous carcinoma in dermoid cyst and third case of mucoepidermoid variant of adenosquamous carcinoma in the literature.

Long-term quality of life outcomes of women treated for early-stage endometrial cancer

2020 ◽  
pp. ijgc-2020-002145
Author(s):  
Saira Sanjida ◽  
Andreas Obermair ◽  
Val Gebski ◽  
Nigel Armfield ◽  
Monika Janda
Keyword(s):  
Quality Of Life ◽  
Endometrial Cancer ◽  
Early Stage ◽  
Age Groups ◽  
Laparoscopic Hysterectomy ◽  
Well Being ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy

ObjectiveTo compare long-term quality of life in women treated for early-stage endometrial cancer with population norms, and to compare quality of life outcomes of patients who had total laparoscopic or total abdominal hysterectomy.MethodsOnce the last enrolled patient had completed 4.5 years of follow-up after surgery, participants in the Laparoscopic Approach to Cancer of the Endometrium (LACE) clinical trial were asked to complete a self-administered questionnaire. Two instruments—EuroQol 5 Dimension 3-level (EQ-5D-3L) and the Functional Assessment of Cancer Treatment-General Population (FACT-GP)—were used to determine quality of life. The mean computed EQ-5D-3L index scores for LACE participants at different age categories were compared with Australian normative scores; and the FACT-GP scores were compared between patients treated with surgical treatments.ResultsOf 760 women originally enrolled in the LACE trial, 259 (50.2%) of 516 women consented to provide long-term follow-up data at a median of 9 years (range 6—12) after surgery. On the EQ-5D-3L, long-term endometrial cancer survivors reported higher prevalence of anxiety/depression than normative levels across all age groups (55–64 years, 30% vs 14.9%; 65–74 years, 30.1% vs 15.8%; ≥75 years, 25.9% vs 10.7%). For women ≥75 years of age, the prevalence of impairment in mobility (57.6% vs 43.3%) and usual activities (58.8% vs 37.9%) was also higher than for population norms. For the FACT-GP, the physical (effect size: −0.28, p<0.028) and functional (effect size: −0.30, p<0.015) well-being sub-scale favored the total laparoscopic hysterectomy compared with total abdominal hysterectomy recipients.ConclusionCompared with population-based norms, long-term endometrial cancer survivors reported higher prevalence of anxiety/depression across all age groups, and deficits in mobility and usual activities for women aged ≥75 years. Physical and functional well-being were better among women who were treated with total laparoscopic hysterectomy than among those receiving total abdominal hysterectomy.

Hysteroscopic injection of tracers in sentinel node detection of endometrial cancer: a feasibility study

2004 ◽  
Vol 191 (2) ◽  
pp. 435-439 ◽  
Author(s):  
Francesco Raspagliesi ◽  
Antonino Ditto ◽  
Shigeki Kusamura ◽  
Rosanna Fontanelli ◽  
Francesca Vecchione ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Sentinel Node ◽  
Feasibility Study ◽  
Sentinel Node Detection
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