210 ROLE OF THE BETA-HEMOLYSIN IN MACROPHAGE ACTIVATION BY GROUP B STREPTOCOCCI EXPOSED TO BETA-LACTAM ANTIBIOTICS.

2004 ◽  
Vol 52 (Suppl 1) ◽  
pp. S294.4-S294
Author(s):  
C T Wright ◽  
K C Brinkmann ◽  
A J Talati ◽  
B K English
Keyword(s):  
Macrophage Activation ◽  
Beta Lactam ◽  
Group B Streptococci ◽  
Beta Lactam Antibiotics ◽  
Group B

Role of bacterial DNA in macrophage activation by group B streptococci☆

2008 ◽  
Vol 10 (10-11) ◽  
pp. 1106-1113 ◽  
Author(s):  
A TALATI ◽  
H KIM ◽  
Y KIM ◽  
A YI ◽  
B ENGLISH
Keyword(s):  
Macrophage Activation ◽  
Group B Streptococci ◽  
Bacterial Dna ◽  
Group B

scholarly journals Point Mutation in the Group B Streptococcal pbp2x Gene Conferring Decreased Susceptibility to β-Lactam Antibiotics

2008 ◽  
Vol 52 (8) ◽  
pp. 2915-2918 ◽  
Author(s):  
Samira Dahesh ◽  
Mary E. Hensler ◽  
Nina M. Van Sorge ◽  
Robert E. Gertz ◽  
Stephanie Schrag ◽  
...  
Keyword(s):  
Point Mutation ◽  
Wild Type ◽  
Beta Lactam ◽  
First Line ◽  
Group B Streptococci ◽  
Beta Lactam Antibiotics ◽  
Allelic Replacement ◽  
Group B

ABSTRACT Beta-lactam antibiotics (BLAs) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x.

Assembly and role of pili in group B streptococci

2006 ◽  
Vol 60 (6) ◽  
pp. 1401-1413 ◽  
Author(s):  
Shaynoor Dramsi ◽  
Elise Caliot ◽  
Isabelle Bonne ◽  
Stephanie Guadagnini ◽  
Marie-Christine Prevost ◽  
...  
Keyword(s):  
Group B Streptococci ◽  
Group B

scholarly journals IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group BStreptococcusInfection

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Luciana Tissi ◽  
Francesco Bistoni ◽  
Manuela Puliti
Keyword(s):  
Mortality Rates ◽  
Group B Streptococci ◽  
Chemokine Production ◽  
Severe Arthritis ◽  
Invasive Infections ◽  
Group B ◽  
Experimental Group ◽  
Anti Inflammatory Cytokine ◽  
Local Levels

IL-4 is an anti-inflammatory cytokine that inhibits the onset and severity in different experimental arthritis models. Group B streptococci (GBS) have been recognized as an ever-growing cause of serious invasive infections in nonpregnant adults. Septic arthritis is a clinical manifestation of GBS infection. To investigate the role of IL-4 in experimental GBS infection, IL-4 deficient or competent mice were inoculated with1×107GBS/mouse. Mortality, appearance of arthritis, GBS growth in the organs, and local and systemic cytokine and chemokine production were examined. IL-4–/– mice showed lower mortality rates but increased severity of arthritis and exhibited a lower microbial load in blood, kidneys, and joints than wt mice. Increased local levels of IL-1β, IL-6, TNF-α, MIP-1α, and MIP-2 accompanied the more severe arthritis in IL-4–/– mice. Our results suggest a detrimental role of IL-4 in GBS sepsis, whereas it plays a beneficial effect on GBS-induced arthritis.

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