C03 A CIS-acting modifier of age at diagnosis of huntington disease in black south african patients

2018 ◽  
Author(s):  
Jessica Levesley ◽  
Fiona Baine ◽  
Marc Ciosi ◽  
Alastair Maxwell ◽  
Darren G Monckton ◽  
...  
Keyword(s):  
South African ◽  
Huntington Disease ◽  
Age At Diagnosis ◽  
Cis Acting ◽  
Black South African ◽  
African Patients

Warfarin Dose and CYP2C Gene Cluster: An African Ancestral-Specific Variant Is a Strong Predictor of Dose in Black South African Patients

2019 ◽  
Vol 23 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Arinao Ndadza ◽  
Zinhle Cindi ◽  
Edson Makambwa ◽  
Emile Chimusa ◽  
Ambroise Wonkam ◽  
...  
Keyword(s):  
Gene Cluster ◽  
South African ◽  
Strong Predictor ◽  
Warfarin Dose ◽  
Black South African ◽  
African Patients

Hematological consequences of a FANCG founder mutation in Black South African patients with Fanconi anemia

2015 ◽  
Vol 54 (3) ◽  
pp. 270-274 ◽  
Author(s):  
Candice Feben ◽  
Jennifer Kromberg ◽  
Rosalind Wainwright ◽  
David Stones ◽  
Janet Poole ◽  
...  
Keyword(s):  
South African ◽  
Fanconi Anemia ◽  
Founder Mutation ◽  
Black South African ◽  
African Patients

Age at Diagnosis of Preinvasive and Invasive Cervical Neoplasia in South Africa: HIV-Positive Versus HIV-Negative Women

2011 ◽  
Vol 21 (2) ◽  
pp. 363-366 ◽  
Author(s):  
Louis-Jacques Jean van Bogaert
Keyword(s):  
South African ◽  
Invasive Cervical Cancer ◽  
Age Distribution ◽  
Age At Diagnosis ◽  
Hiv Positive ◽  
Low Grade ◽  
Black South African ◽  
Hiv Positive Women ◽  
The Mean ◽  
Intraepithelial Lesions

Hypothesis:Human immunodeficiency virus-positive women develop invasive cervical cancer at a significantly earlier age than seronegative women. It is hypothesized that this might result from shorter preinvasive stages.Methods:Prospective observational study of histologically diagnosed 398 low-grade (LGSIL), 738 high-grade intraepithelial lesions (HGSIL), and 1048 invasive cancers (IC) in a black South African population. The study comprised of 493 (22.6%) seropositive women and 1691 (77.4%) seronegative women who served as the controls. All were subdivided into 5-years age bands.Results:The mean age at diagnosis of LGSIL and HGSIL was similar in the cases (t= 0.7;P= 0.49) and the controls (t= 1.2;P= 0.22). The mean age at diagnosis of IC was significantly younger in the HIV-seropositive women than in the HIV-seronegative women (t= 14.0;P< 0.0001). The relative age distribution curves of LGSIL, HGSIL, and IC evolved close to each other in the cases. In the seronegative women, there was an 18-year lag between the peak age distribution of HGSIL and IC.Conclusion:Our data support the hypothesis of a shorter preinvasive stage in HIV-positive women.

The Rheumatoid Wrist in Black South African Patients

2003 ◽  
Vol 28 (4) ◽  
pp. 373-375 ◽  
Author(s):  
N. G. J. MARITZ ◽  
A. J. GERBER ◽  
S. J. GREYLING ◽  
B. B. SANDA
Keyword(s):  
South African ◽  
Joint Involvement ◽  
X Rays ◽  
Surgical Decision ◽  
Larsen Score ◽  
Black South African ◽  
Rheumatoid Wrist ◽  
Black Patients ◽  
African Patients ◽  
The Right

The wrist and hand X-rays of 75 black patients with rheumatoid arthritis were scored according to the Larsen criteria. The mean Larsen score for left hands was 9.6 (range 0–100) and for the right hands was 10:3 (range 0–100), whereas the score for the wrists were 2.5 (range 0–5) for the left and 2.7 (range 0–5) for the right. Our conclusion is that rheumatoid wrist involvement in black patients was more or less the same as reported in other series, but finger joint involvement was considerably less. This finding must influence surgical decision-making and also the interpretation of results of drug trials, whenever black patients are involved.

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