Coxsackie B Viruses and the Post Viral Syndrome in Nuclear Submariners

1988 ◽  
Vol 74 (2) ◽  
pp. 95-95
Author(s):  
P. J. Warnock ◽  
E. J. Bell ◽  
M. H. Riding
Keyword(s):  
Immunosorbent Assay ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igm Antibodies ◽  
Fatigue Syndrome ◽  
B Virus ◽  
Coxsackie B Virus ◽  
Coxsackie B Viruses ◽  
Antibody Capture ◽  
Coxsackie B

SummarySera from 168 submariners, the entire crew of a Polaris submarine, were tested for Coxsackie B Virus (CBV) specific IgM antibodies using a µ antibody capture enzyme linked immunosorbent assay (ELISA). 36 (21%) were positive or weak positive with 22 (13%) confirmed by CBV neutralisation tests (NT) suggesting recent or active CBV infection. The sailors were observed over a two year period during which three patients (2%) developed illnesses suggestive of the post viral fatigue syndrome. These cases, all previously seronegative for CBV did not seroconvert once they became unwell and their illnesses are presumed to have been due to other viruses. The prevalence of CBV infections and the post viral fatigue syndrome in this close and confined community are discussed.

scholarly journals Antibody to Coxsackie B virus in diagnosing postviral fatigue syndrome.

BMJ ◽  
1991 ◽  
Vol 302 (6769) ◽  
pp. 140-143 ◽  
Author(s):  
N A Miller ◽  
H A Carmichael ◽  
B D Calder ◽  
P O Behan ◽  
E J Bell ◽  
...  
Keyword(s):  
Fatigue Syndrome ◽  
B Virus ◽  
Coxsackie B Virus ◽  
Coxsackie B

scholarly journals Coxsackie B virus and postviral fatigue syndrome.

BMJ ◽  
1991 ◽  
Vol 302 (6777) ◽  
pp. 658-659 ◽  
Author(s):  
P Muir ◽  
F Nicholson ◽  
J E Banatvala ◽  
P J Bingley
Keyword(s):  
Fatigue Syndrome ◽  
B Virus ◽  
Coxsackie B Virus ◽  
Coxsackie B

scholarly journals Evaluation of a Commercially Available Immunoglobulin M Capture Enzyme-Linked Immunosorbent Assay Kit for Diagnosing Acute Dengue Infections

1999 ◽  
Vol 6 (5) ◽  
pp. 741-744 ◽  
Author(s):  
Kevin R. Porter ◽  
Susana Widjaja ◽  
Handinata Darmawan ◽  
Lohita ◽  
Sri Hartati Hadiwijaya ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Immunoglobulin M ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibody ◽  
Igm Antibodies ◽  
Paired Samples ◽  
Secondary Infections ◽  
Test Kit ◽  
Antibody Capture ◽  
Negative Controls

ABSTRACT Recently, commercially available kits for the detection of anti-dengue virus (anti-DEN) immunoglobulin M (IgM) antibodies have been developed. These standardized assays have greatly enhanced our ability to effectively diagnose DEN infections. We conducted an evaluation of a test kit manufactured by MRL Diagnostics Inc. that is designed to detect anti-DEN IgM antibodies. Eighty paired samples from DEN-infected individuals were tested by the MRL DEN Fever Virus IgM Capture enzyme-linked immunosorbent assay (ELISA), the PanBio Duo ELISA, the PanBio Rapid Immunochromatographic Test (PRIT), and the IgM-IgG antibody capture (MAC/GAC) ELISA. All infections were confirmed by either PCR-assisted detection of DEN transcripts or by DEN isolation in C6/36 cells. Seventeen paired samples from individuals with no evidence of acute DEN infection were used as negative controls. The PRIT had the best sensitivity (100%), whereas the MAC/GAC ELISA and the PanBio Duo assay had the highest levels of specificity. The MRL ELISA and the PanBio Duo assay were the top performers when taking into consideration both sensitivity and specificity. All assays were able to detect DEN-specific antibodies in samples from patients with either primary or secondary infections, regardless of the infecting DEN serotype.

Myocarditis in Children

1987 ◽  
Vol 9 (3) ◽  
pp. 83-88
Author(s):  
Arno R. Hohn ◽  
Robert E. Stanton
Keyword(s):  
Acute Myocarditis ◽  
B Virus ◽  
Coxsackie B Virus ◽  
Coxsackie B

Acute myocarditis may go undetected. Nearly half of the known cases of myocarditis are caused by coxsackie B virus. Findings in myocarditis are often nonspecific. Echo cardiograms show reduced function. Some cases of myocarditis progress to cardiomyopathy.

Sign in / Sign up

Export Citation Format

Share Document