scholarly journals Reconstructing Fine Details of Small Objects by Using Plasmonic Spectroscopic Data. Part II: The Strong Interaction Regime

2018 ◽  
Vol 11 (3) ◽  
pp. 1931-1953 ◽  
Author(s):  
Habib Ammari ◽  
Matias Ruiz ◽  
Sanghyeon Yu ◽  
Hai Zhang
Keyword(s):  
Strong Interaction ◽  
Spectroscopic Data ◽  
Interaction Regime

Fast ion-induced CO molecule fragmentation in the strong interaction regime

1999 ◽  
Vol 32 (3) ◽  
pp. 631-647 ◽  
Author(s):  
L Adoui ◽  
C Caraby ◽  
A Cassimi ◽  
D Lelièvre ◽  
J P Grandin ◽  
...  
Keyword(s):  
Strong Interaction ◽  
Interaction Regime ◽  
Fast Ion

Synthesis and Anticandidal Activities of Some Aryl (5-Chloro-Benzofuran- 2-yl) Ketoximes

2019 ◽  
Vol 16 (4) ◽  
pp. 427-436
Author(s):  
Ahmet Cagri Karaburun
Keyword(s):  
Antifungal Activity ◽  
13C Nmr ◽  
Strong Interaction ◽  
Active Site ◽  
Spectroscopic Data ◽  
Structure Elucidation ◽  
Pharmacokinetic Profile ◽  
Ergosterol Biosynthesis ◽  
In Silico Study ◽  
Anticandidal Activity

Background: In this study, some aryl (5-chloro-benzofuran-2-yl) ketoximes and their ethers were synthesised to evaluate their antifungal activity against C. albicans, C. glabrata, C. krusei, and C. parapsilosis. </p><p> Methods: The structure elucidation of the compounds was performed by IR, 1H-NMR, 13C-NMR and HR-MS spectroscopic data. ADME parameters of synthesised compounds 2a-2d, 3a-3d, 4a-4d were predicted by an in-silico study and it was determined that all synthesised compounds may have a good pharmacokinetic profile. </p><p> Results: In the anticandidal activity studies, compounds 2c and 3c were found to be the most active compounds. The effect of compound 2c, on ergosterol biosynthesis of C. albicans, was determined by using the LC-MS-MS method. </p><p> Conclusion: It was also docked in the active site of the lanosterol 14&#945;-demethylase enzyme, and shown that there is a strong interaction between compound 2c and enzyme.

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