THE BLOOD COAGULATION MECHANISM OF FROGS, WITH RESPECT TO THE SPECIES SPECIFICITY OF THROMBO PLASTIN, TO INTRACARDIAL THROMBIN INJECTION, AND TO THE EFFECT OF SEASONAL CHANGES

1952 ◽  
Vol 30 (5) ◽  
pp. 420-424
Author(s):  
John J. Spitzer ◽  
Judy A. Spitzer
Keyword(s):  
Prothrombin Time ◽  
Blood Coagulation ◽  
Seasonal Changes ◽  
Thrombin Injection ◽  
Clotting Time ◽  
Coagulation Time ◽  
Coagulation Mechanism ◽  
Significant Difference ◽  
Whole Blood Coagulation Time ◽  
Blood Coagulation Mechanism

1. The prothrombin time of frogs is much shorter using frog rather than rabbit thromboplastin in the determination. The contrary is true for dogs, rabbits, and rats. In guinea pigs there was no significant difference between the two kinds of thromboplastin. 2. The intracardiai injection of thrombin in frogs induces a triphasic response regarding the whole blood coagulation time: (a) shortening, (b) prolongation, and (c) return towards the normal. The return is quicker than in the case of mammals. 3. The following seasonal changes were obtained in “winter” frogs as compared to “summer” animals: (a) pro longed clotting time, (b) increased prothrombin time, and (c) lessened effectiveness of intracardiai thrombin solution. The clotting time with added thrombin was not changed.

A Solid State Whole Blood Coagulation Time Device

1966 ◽  
Vol 46 (4) ◽  
pp. 463-471
Author(s):  
Joseph Beeman ◽  
Alma Miller ◽  
Sam CAmarena
Keyword(s):  
Solid State ◽  
Blood Coagulation ◽  
Whole Blood ◽  
Coagulation Time ◽  
Whole Blood Coagulation Time

Investigations of the Dose of Heparin and Whole Blood Coagulation Time during Endovascular Surgery

1997 ◽  
Vol 3 (2_suppl) ◽  
pp. 215-217 ◽  
Author(s):  
S. Nagai ◽  
A. Kurata ◽  
R. Tanaka ◽  
K. Irikura ◽  
Y. Miyasaka ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Whole Blood ◽  
Initial Level ◽  
Thrombus Formation ◽  
Constant Level ◽  
Bleeding Tendency ◽  
Coagulation Time ◽  
Continuous Administration ◽  
Heparin Administration ◽  
Whole Blood Coagulation Time

We chronologically determined whole blood coagulation time during continuous heparin administration, and investigated optimal doses of heparin in thirty-seven vascular surgery cases. ACT was determined with Hemochron 401. Heparin (2000 IU) was administered by bolus injection at the beginning of intravascular surgery, which was followed by continuous injection of 20 to 160 IU/kg/h. ACT determined before and 30 minutes after heparin administration were compared. There were no complications. ACT was maintained at a nearly constant level by continuous heparin administration. The dose of heparin required to maintain ACT at a level 1.5 to 2 times the initial level was 20 to 60 IU/kg/h. ACT was prolonged by more than three times in two of the ten subjects who were given heparin at a dose of 70 IU/kg/h or more. Continuous administration of heparin allowed maintenance of ACT at a nearly constant level during intravascular surgery. ACT was maintained within the range which is believed to be effective for prevention of thrombus formation (approximately 1.5 to 2.0 times larger than the initial level) by continuous administration of 20 to 60 IU/kg/h of heparin. ACT was, however, prolonged to more than three times the initial level in some subjects who were given 70 IU/kg/h or higher doses, suggesting the risk of a bleeding tendency. Accordingly, it is ideal to continue heparin administration at appropriate doses, while measuring ACT. The results of our study should serve as a useful standard for meeting this goal.

Evaluation of the blood coagulation mechanism and platelet aggregation in individuals with mechanical or biological heart prostheses

2002 ◽  
Vol 13 (2) ◽  
pp. 129-134 ◽  
Author(s):  
C. N. Ferreira ◽  
L. M. Vieira ◽  
L. M. S. Dusse ◽  
C. V. Reis ◽  
C. F. S. Amaral ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Blood Coagulation ◽  
Coagulation Mechanism ◽  
Blood Coagulation Mechanism
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