A new strategy for synthesis of attached rings

2000 ◽  
Vol 78 (6) ◽  
pp. 732-738 ◽  
Author(s):  
Larry E Overman ◽  
Lewis D Pennington
Keyword(s):  
Prins Cyclization ◽  
Pinacol Rearrangement ◽  
Carbon Migration ◽  
New Strategy ◽  
Prins Cyclizations

The first investigation of the use of pinacol-terminated Prins cyclizations to form attached rings is reported. Treatment of triisopropylsilyl ethers of (Z)- or (E)-[2-(6,6-dimethoxyhexylidene)cyclohexanol with SnCl4 provides bicyclic products having attached rings. The approach is synthetically useful in the Z alkylidenecyclohexane series, proceeding selectively by a pathway involving carbon migration in the pinacol rearrangement step, to provide methoxy epimers of 1-(2-methoxycyclohexyl)cyclopentylcarboxaldehyde. Reaction of the corresponding E stereoisomer is more complex and yields a mixture of products resulting from both hydride and carbon migration in the pinacol rearrangement step.Key words: Prins cyclization, pinacol rearrangement, attached rings.

ChemInform Abstract: New Strategy for the Synthesis of the Taxane Diterpenes: Formation of the Eight-Membered B-Ring of Taxol by Semi-Pinacol Rearrangement.

ChemInform ◽  
2010 ◽  
Vol 27 (8) ◽  
pp. no-no
Author(s):  
P. MAGNUS ◽  
L. DIORAZIO ◽  
T. DONOHOE ◽  
M. GILES ◽  
P. PYE ◽  
...  
Keyword(s):  
Pinacol Rearrangement ◽  
New Strategy

New strategy for the synthesis of the taxane diterpenes: formation of the eight-membered B-ring of taxol by semi-pinacol rearrangement

1995 ◽  
pp. 1935 ◽  
Author(s):  
Philip Magnus ◽  
Louis Diorazio ◽  
Timothy Donohoe ◽  
Melvyn Giles ◽  
Philip Pye ◽  
...  
Keyword(s):  
Pinacol Rearrangement ◽  
New Strategy

Ring strain-dictated divergent fluorinating Prins cyclization or semipinacol rearrangement

2017 ◽  
Vol 15 (31) ◽  
pp. 6478-6482 ◽  
Author(s):  
Yi Liu ◽  
Ying-Yeung Yeung
Keyword(s):  
Prins Cyclization ◽  
Ring Strain ◽  
Semipinacol Rearrangement ◽  
Prins Cyclizations

We have developed ring-strain dictated divergent diastereoselective fluorinating Prins cyclizations or semipinacol rearrangements to access a range of tetrahydropyran derivatives.

A new strategy for prenatal diagnosis in a sporadic haemophilia B family

Haemophilia ◽  
2001 ◽  
Vol 7 (4) ◽  
pp. 416-418 ◽  
Author(s):  
M. Acquila ◽  
F. Bottini ◽  
A. Valetto ◽  
D. Caprino ◽  
P. G. Mori ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Haemophilia B ◽  
New Strategy

Guidelines Bring New Strategy in Low-Risk AF

2012 ◽  
Vol 45 (15) ◽  
pp. 12-13
Author(s):  
BRUCE JANCIN
Keyword(s):  
Low Risk ◽  
New Strategy

New Strategy for the Synthesis of 2-Deoxy-C-aryl-nucleoside Frameworks

2006 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
S.M. Mahalingam ◽  
S. Vijayasaradhi ◽  
I.S. Aidhen
Keyword(s):  
New Strategy

Practice Directorate: Practice Directorate pursues new strategy

1995 ◽  
Author(s):  
Scott Sleek ◽  
Keyword(s):  
New Strategy

New strategy to search lead compounds with unique structures from plants

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
T Villani ◽  
K Gustafson ◽  
J Zhen ◽  
JE Simon ◽  
Q Wu
Keyword(s):  
Lead Compounds ◽  
New Strategy

Latin America in Difficult Search of Its Way

2004 ◽  
pp. 107-117
Author(s):  
Z. Romanova
Keyword(s):  
Latin America ◽  
Demographic Structure ◽  
Financial Problems ◽  
Strategy Of Development ◽  
Small Countries ◽  
New Strategy

The article is devoted to the analysis of economic and financial problems and contradictions accumulated in Latin America under conditions of globalization and market liberation. The originated unfavorable changes gave rise to the need of policy correction in big and small countries. The author analyses a new strategy of development adequate for Latin America with its specific geopolitical situation, demographic structure and history.

Reducing Corner Cracks With a New Strategy for Secondary Cooling

2020 ◽  
Author(s):  
A. Mittermair ◽  
S. Lim ◽  
W. Cho ◽  
P. Pennerstorfer
Keyword(s):  
Secondary Cooling ◽  
New Strategy ◽  
Corner Cracks
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