A highly asymmetric direct aldol reaction catalyzed by chiral proline amide – thiourea bifunctional catalysts
Keyword(s):
A series of chiral proline amide – thiourea bifunctional catalysts derived from l-proline and chiral diamine were prepared and successfully applied to highly enantioselective direct aldol reactions of cyclohexanone with various aldehydes in excellent yields (85%–97%), diastereoselectivities (anti/syn > 20:1) and enantioselectivities (up to 91% ee).
2011 ◽
Vol 52
(29)
◽
pp. 3779-3781
◽
Keyword(s):
Keyword(s):
2003 ◽
Vol 44
(30)
◽
pp. 5699-5701
◽
Keyword(s):
2015 ◽
Vol 13
(16)
◽
pp. 4795-4802
◽
Keyword(s):