Conformational analysis of trans-1,4-dihalocyclohexanes

1967 ◽  
Vol 45 (21) ◽  
pp. 2477-2479 ◽  
Author(s):  
Gordon Wood ◽  
E. P. Woo
Keyword(s):  
Low Temperature ◽  
Conformational Analysis ◽  
Conformational Equilibria ◽  
Equatorial Proton

The conformational equilibria of trans-1,4-dibromo- (I), trans-1,4-dichloro- (II), and trans-1,4-bromochloro-cyclohexane (III) were determined by integration of the separate axial and equatorial proton signals at low temperature. The [Formula: see text] values for compounds I, II, and III were found to be approximately 200 cal/mole.

ChemInform Abstract: THE CONFORMATIONAL ANALYSIS OF SATURATED HETEROCYCLES PART 56, SUBSTITUENT EFFECTS IN THE CONFORMATIONAL EQUILIBRIA OF SPIRO-OXAZOLINES

1974 ◽  
Vol 5 (20) ◽  
pp. no-no
Author(s):  
RICHARD A. Y. JONES ◽  
ALAN R. KATRITZKY ◽  
KEITH A. F. RECORD ◽  
ROGER SCATTERGOOD ◽  
JOHN M. SULLIVAN
Keyword(s):  
Conformational Analysis ◽  
Substituent Effects ◽  
Conformational Equilibria ◽  
Saturated Heterocycles

ChemInform Abstract: LOW-TEMPERATURE CYCLIC VOLTAMMETRY. 2. CONFORMATIONAL ANALYSIS OF CYCLIC TETRAALKYLHYDRAZINES

1977 ◽  
Vol 8 (19) ◽  
pp. no-no
Author(s):  
S. F. NELSEN ◽  
L. ECHEGOYEN ◽  
E. L. CLENNAN ◽  
D. H. EVANS ◽  
D. A. CORRIGAN
Keyword(s):  
Cyclic Voltammetry ◽  
Low Temperature ◽  
Conformational Analysis

Conformational analysis of 1,4-disubstituted cyclohexanes. III. trans-1,4-Di(trifluoroacetoxy)cyclohexane

1969 ◽  
Vol 47 (3) ◽  
pp. 429-431 ◽  
Author(s):  
Gordon Wood ◽  
E. P. Woo ◽  
M. H. Miskow
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Free Energy ◽  
Magnetic Resonance ◽  
Low Temperature ◽  
Conformational Analysis ◽  
Integration Method ◽  
Standard Free Energy ◽  
Energy Difference ◽  
Free Energy Difference ◽  
Conformational Free Energy

By the low temperature nuclear magnetic resonance integration method the standard free energy difference between the diequatorial and the diaxial forms of 1-H,4-H-trans-1,4-di(trifluoroacetoxy)-cyclohexane-d8 was found to be 77 ± 5 cal/mole. The conformational free energy (−ΔG0) of the trifluoroacetoxy group in the monosubstituted cyclohexane was 485 ± 4 cal/mole at the same temperature. The non-additivity of the −ΔG0 values is discussed in terms of transannular electrostatic interaction.

scholarly journals A study of the structure–activity relationship of GABAA–benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis

2008 ◽  
Vol 16 (19) ◽  
pp. 8853-8862 ◽  
Author(s):  
Dongmei Han ◽  
F. Holger Försterling ◽  
Xiaoyan Li ◽  
Jeffrey R. Deschamps ◽  
Damon Parrish ◽  
...  
Keyword(s):  
Low Temperature ◽  
Conformational Analysis ◽  
Benzodiazepine Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Bivalent Ligands ◽  
X Ray ◽  
Structure Activity ◽  
Relationship Of
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