Reactions of NO2 and nitrite ion with organic radicals

1984 ◽  
Vol 62 (9) ◽  
pp. 1831-1834 ◽  
Author(s):  
Allen John Elliot ◽  
Anita Sandra Simsons
Keyword(s):  
Hydroxyl Radical ◽  
Organic Radicals ◽  
Radical Scavenger ◽  
Radical Scavengers ◽  
Nitrite Ion ◽  
Aqueous Sodium ◽  
Hydroxyl Radical Scavenger ◽  
Hydroxyalkyl Radicals ◽  
Hydroxyl Radical Scavengers ◽  
Nitrate Solutions

When deoxygenated aqueous sodium nitrate solutions containing an alcohol as a hydroxyl radical scavenger are irradiated, [Formula: see text] depends on the fraction of [Formula: see text] which forms 1-hydroxyalkyl radicals. This arises because [Formula: see text] is not reduced to nitrite by 2- or 3-hydroxyalkyl radicals.Helium- and N2O-saturated sodium nitrite solutions containing different organic hydroxyl radical scavengers were irradiated. Measurements of [Formula: see text] showed that the radicals, ĊH2OH and ĊH2C(CH3)2OH, do not react with the nitrite ion as rapidly as [Formula: see text] and (CH,)2ĊOH. With the latter two radicals, nitric oxide is probably formed from the reaction with the nitrite ion.

Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure

1988 ◽  
Vol 255 (3) ◽  
pp. F438-F443 ◽  
Author(s):  
S. V. Shah ◽  
P. D. Walker
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Hydroxyl Radical ◽  
Tissue Injury ◽  
Iron Chelator ◽  
Radical Scavenger ◽  
Reactive Oxygen Metabolites ◽  
Protective Effects ◽  
Hydroxyl Radical Scavenger ◽  
Hydroxyl Radical Scavengers

Reactive oxygen metabolites, in particular hydroxyl radical, have been shown to be important mediators of tissue injury in several models of acute renal failure. The aim of the present study was to examine the role of hydroxyl radical in glycerol-induced acute renal failure, a model for myoglobinuric renal injury. Rats injected with glycerol alone (8 mg/kg im following dehydration for 24 h) developed significant renal failure compared with dehydrated controls. Rats treated with glycerol and a hydroxyl radical scavenger, dimethylthiourea (DMTU), had significantly lower blood urea nitrogen (BUN) and creatinine. In contrast, urea, which is chemically similar to DMTU but is not a hydroxyl radical scavenger, provided no protection. In addition, DMTU prevented the glycerol-induced rise in renal cortical malondialdehyde content (a measure of lipid peroxidation that serves as a marker of free radical-mediated tissue injury). A second hydroxyl radical scavenger, sodium benzoate, had a similar protective effect on renal function (as measured by both BUN and creatinine). Because the generation of hydroxyl radical in biological systems requires the presence of a trace metal such as iron, we also examined the effect of the iron chelator, deferoxamine on glycerol-induced renal failure. Deferoxamine was also protective. The interventional agents were also associated with a marked reduction in histological evidence of renal damage. The protective effects of two hydroxyl radical scavengers as well as an iron chelator implicate a role for hydroxyl radical in glycerol-induced acute renal failure.

Post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by hydroxyl radical scavengers and iron chelators

2008 ◽  
Vol 393 (3) ◽  
pp. 303-310 ◽  
Author(s):  
Mohammed R. Moussavian ◽  
Jan E. Slotta ◽  
Otto Kollmar ◽  
Michael D. Menger ◽  
Gernot Gronow ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Iron Chelators ◽  
Renal Tubules ◽  
Radical Scavengers ◽  
Hydroxyl Radical Scavengers

scholarly journals A NOVEL HYDROXYL RADICAL SCAVENGER, NICARAVEN, ATTENUATES ISCHEMIA REPERFUSION INJURY OF THE LIVER

1998 ◽  
Vol 65 (Supplement) ◽  
pp. 148
Author(s):  
R. Yokota ◽  
T. Shimamura ◽  
T. Suzuki ◽  
M. Fukai ◽  
M. Taniguchi ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Radical Scavenger ◽  
Hydroxyl Radical Scavenger

Role of hydroxyl radical scavengers dimethyl sulfoxide, alcohols and methional in the inhibition of prostaglandin biosynthesis

1976 ◽  
Vol 11 (4) ◽  
pp. 599-607 ◽  
Author(s):  
Rao V. Panganamala ◽  
Hari M. Sharma ◽  
Richard E. Heikkila ◽  
Jack C. Geer ◽  
David G. Cornwell
Keyword(s):  
Hydroxyl Radical ◽  
Dimethyl Sulfoxide ◽  
Radical Scavengers ◽  
Prostaglandin Biosynthesis ◽  
Hydroxyl Radical Scavengers

Synthesis of New Carnosine Derivatives ofβ-Cyclodextrin and Their Hydroxyl Radical Scavenger Ability

2002 ◽  
Vol 85 (6) ◽  
pp. 1633-1643 ◽  
Author(s):  
Diego La Mendola ◽  
Salvatore Sortino ◽  
Graziella Vecchio ◽  
Enrico Rizzarelli
Keyword(s):  
Hydroxyl Radical ◽  
Radical Scavenger ◽  
Hydroxyl Radical Scavenger
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