Effects of serotonin on the physiology of the rabbit small intestine

2000 ◽  
Vol 78 (5) ◽  
pp. 359-366 ◽  
Author(s):  
M T Salvador ◽  
M D Murillo ◽  
M C Rodríguez-Yoldi ◽  
A I Alcalde ◽  
J E Mesonero ◽  
...  
Keyword(s):  
Small Intestine ◽  
Intestinal Transport ◽  
Inhibitory Effect ◽  
Mechanical Activity ◽  
Intestinal Physiology ◽  
Rabbit Jejunum ◽  
Rabbit Small Intestine ◽  
Intestine Motility ◽  
Transport Of Ions ◽  
Small Intestine Motility

Serotonin has been shown to alter the intestinal transport of ions and intestinal motility. These effects may interfere with each other, modulating the whole physiology of the intestine. We have previously shown that serotonin also alters the transport of nutrients. Thus, the aims of the present work were to determine the possible interference between the secretagogue effect of serotonin and the mechanism by which serotonin inhibits the absorption of nutrients, and to study the effect of serotonin on the digestive activity of nutrients of the brush border membrane jejunum enterocyte in the rabbit. The results show that the secretagogue effect of serotonin neither affects the inhibitory effect of serotonin on the intestinal absorption of the nutrients, nor affects the activity of Na+/K+-ATPase. The activity of sucrase and aminopeptidase N was also not affected by serotonin in the rabbit jejunum. Finally, we also studied different parameters of the motility in the rabbit small intestine. Serotonin seemed to stimulate the motility of the rabbit small intestine by increasing integrated mechanical activity and tone of muscle fibers in duodenum, jejunum, and ileum. In conclusion, serotonin might alter or modulate the whole intestinal physiology. Key words: serotonin, small intestine, motility, absorption, rabbit.

Alterations of small intestine motility by bacteria and their enterotoxins

2011 ◽  
Author(s):  
John R. Mathias ◽  
Mary H. Clench
Keyword(s):  
Small Intestine ◽  
Intestine Motility ◽  
Small Intestine Motility

Small intestine motility

2000 ◽  
Vol 16 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Allison Malcolm ◽  
John E. Kellow
Keyword(s):  
Small Intestine ◽  
Intestine Motility ◽  
Small Intestine Motility

Central and peripheral action of GABAA and GABAB agonists on small intestine motility in rats

1988 ◽  
Vol 150 (1-2) ◽  
pp. 163-169 ◽  
Author(s):  
Marie Jose Fargeas ◽  
Jean Fioramonti ◽  
Lionel Bueno
Keyword(s):  
Small Intestine ◽  
Intestine Motility ◽  
Peripheral Action ◽  
Small Intestine Motility

The correction of postvagotomy disturbances of small intestine motility with antihypoxants and antioxidants

1993 ◽  
Vol 116 (2) ◽  
pp. 916-918
Author(s):  
A. P. Ettinger ◽  
A. Yu. Tsibulevskii
Keyword(s):  
Small Intestine ◽  
Intestine Motility ◽  
Small Intestine Motility

Gestational evolution of small intestine motility in preterm and term infants

1989 ◽  
Vol 115 (4) ◽  
pp. 646-651 ◽  
Author(s):  
C.L. Berseth
Keyword(s):  
Small Intestine ◽  
Term Infants ◽  
Intestine Motility ◽  
Small Intestine Motility

Resistance of the Small Intestine (Motility) Against Stress

1956 ◽  
Vol 9 (3) ◽  
pp. 484-486
Author(s):  
J. Clifford Stickney ◽  
David W. Northup ◽  
Edward J. Van Liexre
Keyword(s):  
Small Intestine ◽  
Intestine Motility ◽  
Small Intestine Motility

Inhibition of small intestine motility by cromakalim (BRL 34915)

1988 ◽  
Vol 154 (3) ◽  
pp. 335-337 ◽  
Author(s):  
Karl-Heinz Buchheit ◽  
Adrien Bertholet
Keyword(s):  
Small Intestine ◽  
Intestine Motility ◽  
Small Intestine Motility

Inhibitory Effect of Baicalin on Disaccharidase in Small Intestine

2009 ◽  
Vol 7 (2) ◽  
pp. 129-133 ◽  
Author(s):  
Shu-Jing GU ◽  
Li LIU ◽  
Yao-Wu LIU ◽  
Xin-Yue JING ◽  
Xiao-Dong LIU ◽  
...  
Keyword(s):  
Small Intestine ◽  
Inhibitory Effect

Changes in K+, Na+, and H+ permeability of vesicles from isolated apical epitheliocyte membranes of the rabbit small intestine during Ca-activated lipolysis

1986 ◽  
Vol 102 (1) ◽  
pp. 904-907
Author(s):  
V. I. Sorokovoi ◽  
V. A. Shakhlamov ◽  
G. M. Nikitina
Keyword(s):  
Small Intestine ◽  
Rabbit Small Intestine

Regulation of intestinal glucose transport

1992 ◽  
Vol 70 (9) ◽  
pp. 1201-1207 ◽  
Author(s):  
D. J. Philpott ◽  
J. D. Butzner ◽  
J. B. Meddings
Keyword(s):  
Small Intestine ◽  
Glucose Transport ◽  
Intestinal Adaptation ◽  
Basolateral Membrane ◽  
Intestinal Transport ◽  
Glucose Absorption ◽  
Dietary Carbohydrate ◽  
Adaptive Responses ◽  
Carbohydrate Levels ◽  
Specific Regulation

The small intestine is capable of adapting nutrient transport in response to numerous stimuli. This review examines several possible mechanisms involved in intestinal adaptation. In some cases, the enhancement of transport is nonspecific, that is, the absorption of many nutrients is affected. Usually, increased transport capacity in these instances can be attributed to an increase in intestinal surface area. Alternatively, some conditions induce specific regulation at the level of the enterocyte that affects the transport of a particular nutrient. Since the absorption of glucose from the intestine is so well characterized, it serves as a useful model for this type of intestinal adaptation. Four potential sites for the specific regulation of glucose transport have been described, and each is implicated in different situations. First, mechanisms at the brush-border membrane of the enterocyte are believed to be involved in the upregulation of glucose transport that occurs in streptozotocin-induced diabetes mellitus and alterations in dietary carbohydrate levels. Also, factors that increase the sodium gradient across the enterocyte may increase the rate of glucose transport. It has been suggested that an increase in activity of the basolaterally located Na+–K+ ATPase could be responsible for this phenomena. The rapid increase in glucose uptake seen in hyperglycemia seems to be mediated by an increase in both the number and activity of glucose carriers located at the basolateral membrane. More recently, it was demonstrated that mechanisms at the basolateral membrane also play a role in the chronic increase in glucose transport observed when dietary carbohydrate levels are increased. Finally, alterations in tight-junction permeability enhance glucose absorption from the small intestine. The possible signals that prompt these adaptive responses in the small intestine include glucose itself and humoral as well as enteric nervous interactions.Key words: intestinal transport, glucose transport, intestinal adaptation.

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