Changes in K+, Na+, and H+ permeability of vesicles from isolated apical epitheliocyte membranes of the rabbit small intestine during Ca-activated lipolysis

1986 ◽  
Vol 102 (1) ◽  
pp. 904-907
Author(s):  
V. I. Sorokovoi ◽  
V. A. Shakhlamov ◽  
G. M. Nikitina

1984 ◽  
Vol 97 (1) ◽  
pp. 134-136 ◽  
Author(s):  
V. K. Rybal'chenko ◽  
P. V. Pogrebnoi ◽  
T. G. Gruzina ◽  
V. I. Karamushka


Author(s):  
Giustina Danisi ◽  
Madeleine Rouiller ◽  
Josée Vitus ◽  
Petr Jirounek ◽  
Jean-Philippe Bonjour ◽  
...  


1977 ◽  
Vol 232 (2) ◽  
pp. E109
Author(s):  
S Yokoyama ◽  
T Ozaki ◽  
T Kajitsuka

Excitation conduction in Meissner's plexus of the rabit small intestine was investigated by analyzing the records of potentials evoked by a single electrical stimulus applied to this plexus. Experiments were performed on the Meissner's plexus that remained attached to the circular muscle after the longitudinal muscle and mucous membrane were removed from intestinal segment. Conduction velocities of nerve impulses were 0.3-0.7 m/s, chronaxie of the nerve bundle was 0.06-0.12 ms. While the distance between the stimulating and recording electrodes was increased, the latency of evoked potentials was prolonged, the number increased, and the amplitude decreased; no potentials could be recorded when the distance was more than 4 mm. Evoked potentials recorded at relatively long conduction distance were reduced in amplitude or abolished after a repeated stimulation with high frequencies above 50/s, after hexamethonium application, and in a state of lack of oxygen. It was concluded that, in Meissner's plexus, nerve impulses spread through multiple pathways and make synaptic transmission at a relatively short conduction distance.



1995 ◽  
Vol 67 ◽  
pp. 191
Author(s):  
Ken-ichi Ozak ◽  
Hisanori Takanashi ◽  
Kenji Yogo ◽  
Michitaka Akima ◽  
Hiroshi Koga ◽  
...  


1979 ◽  
Vol 77 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Howard P. Sherr ◽  
Richard B. Mertens


1982 ◽  
Vol 242 (4) ◽  
pp. G360-G363 ◽  
Author(s):  
J. R. Mathias ◽  
J. Nogueira ◽  
J. L. Martin ◽  
G. M. Carlson ◽  
R. A. Giannella

Escherichia coli heat-stable enterotoxin is a low-molecular-weight substance that has been shown to induce the active secretion of fluid and electrolytes in the small intestine. In this study, we have characterized the effects of purified E. coli heat-stable toxin (ST, strain 18D, serotype 042:K86:H37) on the motility of rabbit small intestine by using myoelectric recording techniques. Substances, such as cholera toxin, that activate the adenylate cyclase-cAMP system induced predominantly migrating action-potential complex activity. E. coli ST, a toxin that activates the guanylate cyclase-cGMP system, was infused into isolated in vivo ileal loops of New Zealand White rabbits. Inactivated toxin was also studied by exposing the ST to 1 mM dithiothreitol for 90 min. Active E. coli ST induced only repetitive bursts of action potentials. When the toxin was inactivated with dithiothreitol, no alteration in myoelectric activity was observed. We speculate that repetitive bursts of action-potential activity may represent a virulent factor of the bacterium, altering motor activity to slow transit and allowing for bacterial proliferation and invasion.



1995 ◽  
Vol 67 ◽  
pp. 191
Author(s):  
Kenii Yogo ◽  
Hisanori Takanashi ◽  
Ken-ichi Ozaki ◽  
Makoto Ikuta ◽  
Michitaka Akima ◽  
...  




1985 ◽  
Vol 63 (5) ◽  
pp. 449-452
Author(s):  
H. P. Baer ◽  
R. Vriend ◽  
A. Murji

The adenosine derivative, 2′3′-di-O-nitro-(5′-N-ethylcarboxamido)adenosine (DINECA), caused relaxation in several isolated smooth muscle preparations including guinea pig taenia caeci, beef coronary arteries, and rabbit small intestine. In rabbit small intestine the response profile of DINECA action differed from that of established adenosine receptor agonists and, in contrast with the latter, its relaxant effect was only partially reversed by the antagonist 8-p-sulfophenyltheophylline. Concentration–response curves to 5′-(N-ethylcarboxamido)adenosine (NECA), but not those to DINECA, were significantly shifted to the right by 100 μM of 8-sulfophenyltheophylline. Tissues exposed previously to DINECA became refractory to adenosine, an effect not observed with tissues exposed to NECA, suggesting that DINECA became bound to adenosine receptors. Adenylate cyclase from neuroblastoma cells, containing Ra-type adenosine receptors, was stimulated by 2-chloroadenosine and NECA but not by DINECA. The results suggest that most of the smooth muscle relaxant actions of DINECA are not due to interaction with adenosine receptors but are probably due to its function as a nitrate. However, DINECA appears to interact with adenosine receptors, causing long lasting inhibition of adenosine action in rabbit intestine. Such actions may contribute to the overall response to DINECA application in vivo, although lowering of blood pressure due to the high reactivity of the vasculature to nitrates may be the initial and major effect.



Chirality ◽  
2001 ◽  
Vol 13 (3) ◽  
pp. 164-169 ◽  
Author(s):  
Tomoo Itoh ◽  
Kiyoko Ono ◽  
Kei-Ichi Koido ◽  
Yin-Hua Li ◽  
Hideo Yamada


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