Channel Structure and Function

2013 ◽  
pp. 61-103
Keyword(s):  
Structure And Function ◽  
Channel Structure ◽  
And Function

Role of the C-Terminus of the High-Conductance Calcium-Activated Potassium Channel in Channel Structure and Function

Biochemistry ◽  
2005 ◽  
Vol 44 (30) ◽  
pp. 10135-10144 ◽  
Author(s):  
William A. Schmalhofer ◽  
Manuel Sanchez ◽  
Ge Dai ◽  
Ashvin Dewan ◽  
Lorena Secades ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Structure And Function ◽  
Channel Structure ◽  
C Terminus ◽  
And Function ◽  
Calcium Activated Potassium Channel ◽  
High Conductance

Polyethylenimine-Mediated DNA Transfection of Peripheral and Central Neurons in Primary Culture: Probing Ca2+Channel Structure and Function with Antisense Oligonucleotides

1996 ◽  
Vol 7 (3) ◽  
pp. 239-246 ◽  
Author(s):  
Régis C. Lambert ◽  
Yves Maulet ◽  
Jean-Luc Dupont ◽  
Serge Mykita ◽  
Peter Craig ◽  
...  
Keyword(s):  
Primary Culture ◽  
Antisense Oligonucleotides ◽  
Structure And Function ◽  
Channel Structure ◽  
Dna Transfection ◽  
Central Neurons ◽  
And Function

scholarly journals A Prokaryotic Perspective on Pentameric Ligand-Gated Ion Channel Structure and Function

2012 ◽  
Vol 102 (3) ◽  
pp. 417a
Author(s):  
Raimund Dutzler
Keyword(s):  
Ion Channel ◽  
Structure And Function ◽  
Channel Structure ◽  
And Function

scholarly journals Refinement of a Cryo-EM Structure of hERG: Bridging Structure and Function

2020 ◽  
Author(s):  
H.M. Khan ◽  
J. Guo ◽  
H.J. Duff ◽  
D. P. Tieleman ◽  
S. Y. Noskov
Keyword(s):  
Molecular Dynamics ◽  
High Resolution ◽  
Salt Bridge ◽  
Structure And Function ◽  
Channel Structure ◽  
Salt Bridges ◽  
Voltage Sensing ◽  
Chain Conformations ◽  
And Function ◽  
Voltage Sensing Domain

AbstractThe human ether-a-go-go-related gene (hERG) encodes the voltage gated potassium channel (KCNH2 or Kv11.1, commonly known as hERG). This channel plays a pivotal role in the stability of phase 3 repolarization of the cardiac action potential. Although a high-resolution cryo-EM structure is available for its depolarized (open) state, the structure surprisingly did not feature many functionally important interactions established by previous biochemical and electrophysiology experiments. Using Molecular Dynamics Flexible Fitting (MDFF), we refined the structure and recovered the missing functionally relevant salt bridges in hERG in its depolarized state. We also performed electrophysiology experiments to confirm the functional relevance of a novel salt bridge predicted by our refinement protocol. Our work shows how refinement of a high-resolution cryo-EM structure helps to bridge the existing gap between the structure and function in the voltage-sensing domain (VSD) of hERG.Statement of SignificanceCryo-EM has emerged as a major breakthrough technique in structural biology of membrane proteins. However, even high-resolution Cryo-EM structures contain poor side chain conformations and interatomic clashes. A high-resolution cryo-EM structure of hERG1 has been solved in the depolarized (open) state. The state captured by Cryo-EM surprisingly did not feature many functionally important interactions established by previous experiments. Molecular Dynamics Flexible Fitting (MDFF) used to enable refinement of the hERG1 channel structure in complex membrane environment re-establishing key functional interactions in the voltage sensing domain.

scholarly journals Emerging Models of Glutamate Receptor Ion Channel Structure and Function

Structure ◽  
2011 ◽  
Vol 19 (10) ◽  
pp. 1370-1380 ◽  
Author(s):  
Mark L. Mayer
Keyword(s):  
Ion Channel ◽  
Glutamate Receptor ◽  
Structure And Function ◽  
Channel Structure ◽  
And Function

scholarly journals Probing Ion Channel Structure and Function Using Light-Sensitive Amino Acids

2018 ◽  
Vol 43 (6) ◽  
pp. 436-451 ◽  
Author(s):  
Viktoria Klippenstein ◽  
Laetitia Mony ◽  
Pierre Paoletti
Keyword(s):  
Amino Acids ◽  
Ion Channel ◽  
Structure And Function ◽  
Channel Structure ◽  
And Function

Correlating ion channel structure and function

2021 ◽  
Author(s):  
Philipp A.M. Schmidpeter ◽  
Crina M. Nimigean
Keyword(s):  
Ion Channel ◽  
Structure And Function ◽  
Channel Structure ◽  
And Function
Sign in / Sign up

Export Citation Format

Share Document