Project portfolio management involves multiple projects, of which risk regulation is different from the risk regulation of single projects especially in information technology application. In addition to considering each project's own risk, it must consider risk of project portfolio from a broader perspective. Issues of risk regulation are more complex, therefore its risk regulation requires new management approaches. This paper draws on Hall's three-dimensional management structure, respectively, from the four aspects: project portfolio management process, project portfolio risk regulation process, project portfolio risk regulation approach and project portfolio risk regulation organization, to establish a project portfolio risk regulation four-dimensional system (tlkc system) by applied-information technology. It provides a theoretical guidance for current risk regulation of project portfolio management, contributes project-oriented enterprises to establish suitable project portfolio risk regulation measures with their own circumstances, which is a necessary complement for project portfolio theory.