Bayesian empirical likelihood and variable selection for censored linear model with applications to acute myelogenous leukemia data

2019 ◽  
Vol 12 (05) ◽  
pp. 1950050
Author(s):  
Chun-Jing Li ◽  
Hong-Mei Zhao ◽  
Xiao-Gang Dong

This paper develops the Bayesian empirical likelihood (BEL) method and the BEL variable selection for linear regression models with censored data. Empirical likelihood is a multivariate analysis tool that has been widely applied to many fields such as biomedical and social sciences. By introducing two special priors to the empirical likelihood function, we find two obvious superiorities of the BEL methods, that is (i) more precise coverage probabilities of the BEL credible region and (ii) higher accuracy and correct identification rate of the BEL model selection using an hierarchical Bayesian model, vs. some current methods such as the LASSO, ALASSO and SCAD. The numerical simulations and empirical analysis of two data examples show strong competitiveness of the proposed method.

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Qing-Yan Yin ◽  
Jun-Li Li ◽  
Chun-Xia Zhang

As a pivotal tool to build interpretive models, variable selection plays an increasingly important role in high-dimensional data analysis. In recent years, variable selection ensembles (VSEs) have gained much interest due to their many advantages. Stability selection (Meinshausen and Bühlmann, 2010), a VSE technique based on subsampling in combination with a base algorithm like lasso, is an effective method to control false discovery rate (FDR) and to improve selection accuracy in linear regression models. By adopting lasso as a base learner, we attempt to extend stability selection to handle variable selection problems in a Cox model. According to our experience, it is crucial to set the regularization region Λ in lasso and the parameter λmin properly so that stability selection can work well. To the best of our knowledge, however, there is no literature addressing this problem in an explicit way. Therefore, we first provide a detailed procedure to specify Λ and λmin. Then, some simulated and real-world data with various censoring rates are used to examine how well stability selection performs. It is also compared with several other variable selection approaches. Experimental results demonstrate that it achieves better or competitive performance in comparison with several other popular techniques.


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