INTRACELLULAR ANTIBODIES (INTRABODIES) FOR GENE THERAPY OF INFECTIOUS DISEASES

1997 ◽  
Vol 51 (1) ◽  
pp. 257-283 ◽  
Author(s):  
Isaac J. Rondon ◽  
and Wayne A. Marasco
1994 ◽  
Vol 10 (4) ◽  
pp. 139-144 ◽  
Author(s):  
Eli Gilboa ◽  
Clay Smith

1998 ◽  
Vol 11 (1) ◽  
pp. 42-56 ◽  
Author(s):  
Bruce A. Bunnell ◽  
Richard A. Morgan

SUMMARY Gene therapy is being investigated as an alternative treatment for a wide range of infectious diseases that are not amenable to standard clinical management. Approaches to gene therapy for infectious diseases can be divided into three broad categories: (i) gene therapies based on nucleic acid moieties, including antisense DNA or RNA, RNA decoys, and catalytic RNA moieties (ribozymes); (ii) protein approaches such as transdominant negative proteins and single-chain antibodies; and (iii) immunotherapeutic approaches involving genetic vaccines or pathogen-specific lymphocytes. It is further possible that combinations of the aforementioned approaches will be used simultaneously to inhibit multiple stages of the life cycle of the infectious agent.


Author(s):  
Gökhan M. Mutlu ◽  
H. Ari Jaffe

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