Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases

2017 ◽  
Vol 31 (5) ◽  
pp. 883-895 ◽  
Author(s):  
Geoffrey L. Rogers ◽  
Paula M. Cannon
Keyword(s):  
Gene Therapy ◽  
Human Immunodeficiency Virus ◽  
Infectious Diseases ◽  
Immunodeficiency Virus

scholarly journals Anti- cyclic citrullinated peptide antibodies in tuberculosis and human immunodeficiency virus

2020 ◽  
Vol 7 (5) ◽  
pp. 804
Author(s):  
Rakesh K. Yadav ◽  
Raj K. ◽  
Kachnar V. ◽  
Manoj K. Mathur ◽  
Amitabh D. Shukla
Keyword(s):  
Rheumatoid Arthritis ◽  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Pulmonary Tuberculosis ◽  
Infectious Diseases ◽  
Human Immunodeficiency Virus Infection ◽  
Extra Pulmonary Tuberculosis ◽  
Immunodeficiency Virus ◽  
Extra Pulmonary ◽  
Citrullinated Peptide

Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like tuberculosis, human immunodeficiency virus infection, etc.Methods: Eighty patients of tuberculosis both pulmonary and extra-pulmonary tuberculosis and thirty patients of human immunodeficiency virus were enrolled in this study from inpatient and outpatient departments from September 2018 to August 2019. Anti-CCP antibody test was done in all the patient by enzyme linked immunosorbent assay.Results: Fifty-three patients were of pulmonary tuberculosis, 27 patients were extra-pulmonary tuberculosis and 30 patients were human immunodeficiency virus infection. Of the 53 cases of pulmonary tuberculosis, 21 (39.6%) cases were positive for anti-CCP antibodies and 32 (60.4%) cases were negative for the same. Of the 27 cases of extra-pulmonary tuberculosis, 3(11.1%) cases were positive for anti-CCP antibodies and 24 (88.9%) cases were negative. Of the 53 patients of pulmonary tuberculosis, 16 were sputum positive and 37 were sputum negative. Of those withsputum positive 9 (56.2%) cases were positive for anti-CCP antibodies and those with sputum negative, 12 (32.4%) cases were positive for anti-CCP antibodies. Of the 30 cases of human immunodeficiency virus, 5 (16.7%) cases were positive for anti-CCP antibodies and 25 (83.3%) cases were negative.Conclusions: Anti-CCP can be positive in cases of infectious diseases like tuberculosis and human immunodeficiency virus. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary tuberculosis. Anti-CCP, thus is not very specific for rheumatoid arthritis.

scholarly journals Prophylaxis with Trimethoprim‐Sulfamethoxazole for Human Immunodeficiency Virus–Infected Patients: Impact on Risk for Infectious Diseases

2001 ◽  
Vol 33 (3) ◽  
pp. 393-398 ◽  
Author(s):  
Mark S. Dworkin ◽  
John Williamson ◽  
Jeffrey L. Jones ◽  
Jonathan E. Kaplan ◽  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Infectious Diseases ◽  
Immunodeficiency Virus

Significant Publications on Infectious Diseases Pharmacotherapy in 2017

2018 ◽  
Vol 32 (5) ◽  
pp. 534-545 ◽  
Author(s):  
Erik W. Skoglund ◽  
Kierra M. Dotson ◽  
Casey J. Dempsey ◽  
Christy P. Su ◽  
Farnaz Foolad ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Infectious Diseases ◽  
Acquired Immunodeficiency Syndrome ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Hiv Aids

Purpose: The most significant peer-reviewed articles pertaining to infectious diseases (ID) pharmacotherapy, as selected by panels of ID pharmacists, are summarized. Summary: Members of the Houston Infectious Diseases Network (HIDN) were asked to nominate peer-reviewed articles that they believed most contributed to the practice of ID pharmacotherapy in 2017, including the areas of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). A list of 33 articles related to general ID pharmacotherapy and 4 articles related to HIV/AIDS was compiled. A survey was distributed to members of the Society of Infectious Diseases Pharmacists (SIDP) for the purpose of selecting 10 articles believed to have made the most significant impact on general ID pharmacotherapy and the single significant publication related to HIV/AIDS. Of 524 SIDP members who responded, 221 (42%) and 95 (18%) members voted for general pharmacotherapy- and HIV/AIDS-related articles, respectively. The highest ranked articles are summarized below. Conclusion: Remaining informed on the most significant ID-related publications is a challenge when considering the large number of ID-related articles published annually. This review of significant publications in 2017 may aid in that effort.

Development of lentiviral vectors for gene therapy for human diseases

Blood ◽  
2000 ◽  
Vol 95 (8) ◽  
pp. 2499-2504 ◽  
Author(s):  
Gary L. Buchschacher ◽  
Flossie Wong-Staal
Keyword(s):  
Gene Therapy ◽  
Human Immunodeficiency Virus ◽  
Retroviral Vectors ◽  
Retroviral Vector ◽  
Vector System ◽  
Human Pathogen ◽  
Vector Systems ◽  
Immunodeficiency Virus ◽  
Clinical Gene Therapy ◽  
Made In

Retroviral vectors derived from murine retroviruses are being used in several clinical gene therapy trials. Recently, progress has been made in the development of vectors based on the lentivirus genus of retroviruses, which ironically includes a major human pathogen, human immunodeficiency virus (HIV). As these vector systems for clinical gene transfer are developed, it is important to understand the rationale behind their design and development. This article reviews the fundamental features of retrovirus replication and of the elements necessary for development of a retroviral vector system, and it discusses why vector systems based on HIV or other lentiviruses have the potential to become important tools in clinical gene therapy.

scholarly journals Heterologous Human Immunodeficiency Virus Type 1 Lentiviral Vectors Packaging a Simian Immunodeficiency Virus-Derived Genome Display a Specific Postentry Transduction Defect in Dendritic Cells

2003 ◽  
Vol 77 (17) ◽  
pp. 9295-9304 ◽  
Author(s):  
Caroline Goujon ◽  
Loraine Jarrosson-Wuilleme ◽  
Jeanine Bernaud ◽  
Dominique Rigal ◽  
Jean-Luc Darlix ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Human Immunodeficiency Virus ◽  
Dendritic Cells ◽  
Simian Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cell Types ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Heterologous lentiviral vectors (LVs) represent a way to address safety concerns in the field of gene therapy by decreasing the possibility of genetic recombination between vector and packaging constructs and the generation of replication-competent viruses. Using described LVs based on human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus MAC251 (SIVMAC251), we asked whether heterologous virion particles in which trans-acting factors belonged to HIV-1 and cis elements belonged to SIVMAC251 (HIV-siv) would behave as parental homologous vectors in all cell types. To our surprise, we found that although the heterologous HIV-siv vector was as infectious as its homologous counterpart in most human cells, it was defective in the transduction of dendritic cells (DCs) and, to a lesser extent, macrophages. In DCs, the main postentry defect was observed in the formation of two-long-terminal-repeat circles, despite the fact that full-length proviral DNA was being synthesized and was associated with the nucleus. Taken together, our data suggest that heterologous HIV-siv vectors display a cell-dependent infectivity defect, most probably at a post-nuclear entry migration step. As homologous HIV and SIV vectors do transduce DCs, we believe that these results underscore the importance of a conserved interaction between cis elements and trans-acting viral factors that is lost or suboptimal in heterologous vectors and essential only in the transduction of certain cell types. For gene therapy purposes, these findings indicate that the cellular tropism of LVs can be modulated not only through the use of distinct envelope proteins or tissue-specific promoters but also through the specific combinatorial use of packaging and transfer vector constructs.

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