Effect of GH/IGF-I deficiency on long-term renal changes and urinary albumin excretion in diabetic dwarf rats

1997 ◽  
Vol 272 (5) ◽  
pp. E918-E924 ◽  
Author(s):  
H. Gronbaek ◽  
P. Volmers ◽  
S. F. Bjorn ◽  
R. Osterby ◽  
H. Orskov ◽  
...  
Keyword(s):  
Diabetic Kidney Disease ◽  
Urinary Albumin Excretion ◽  
Diabetic Rats ◽  
Urinary Albumin ◽  
Albumin Excretion ◽  
Igf I ◽  
Renal Changes ◽  
Rat Strain ◽  
Intact Rats

Growth hormone (GH) and insulin-like growth factor I (IGF-I) may play a role in early diabetic renal and glomerular growth and in the later development of experimental diabetic kidney disease. Rats from a genetic GH/IGF-I-deficient dwarf rat strain were made streptozotocin diabetic and were compared with nondiabetic dwarf rats. GH/IGF-I-intact rats with and without diabetes served as controls. After 6 mo of diabetes, kidney weight and total glomerular volume increased significantly in GH/IGF-I-intact diabetic rats compared with the nondiabetic GH/IGF-I-intact rats (P < 0.05), whereas the diabetic dwarf rats had insignificant changes compared with dwarf control rats. By the end of the study, urinary albumin excretion (UAE) increased from similar base levels of approximately 15-20 micrograms/24 h to 473 +/- 52 (SE) micrograms/24 h in GH/IGF-I-intact diabetic rats compared with 151 +/- 32 micrograms/24 h in diabetic dwarf rats (P < 0.01). In conclusion, isolated GH/IGF-I deficiency reduces the degree of renal and glomerular hypertrophy and the increase in UAE after 6 mo of experimental diabetes in GH/IGF-I-deficient rats.

scholarly journals Effect of Pentoxifylline on Renal Function and Urinary Albumin Excretion in Patients with Diabetic Kidney Disease: The PREDIAN Trial

2014 ◽  
Vol 26 (1) ◽  
pp. 220-229 ◽  
Author(s):  
Juan F. Navarro-González ◽  
Carmen Mora-Fernández ◽  
Mercedes Muros de Fuentes ◽  
Jesús Chahin ◽  
María L. Méndez ◽  
...  
Keyword(s):  
Renal Function ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Diabetic Kidney ◽  
Albumin Excretion

Long-term low temperature sauna reduces urinary albumin excretion in the 5/6 nephrectomy mouse model

Physiotherapy ◽  
2015 ◽  
Vol 101 ◽  
pp. e549
Author(s):  
C. Hayashida ◽  
Y. Iwashita ◽  
K. Murakami ◽  
T. Nakamura ◽  
K. Wataru ◽  
...  
Keyword(s):  
Low Temperature ◽  
Mouse Model ◽  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Albumin Excretion

Abstract 3781: A Reduction in Urinary Albumin Excretion is Associated with a Decrease in 10-year Cardiovascular Mortality in Hypertensive Type 2 Diabetic Patients

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Raymond Estacio ◽  
Joseph Coll ◽  
Rita Dale ◽  
Becki Bucher-Bartelson ◽  
Mori J Krantz
Keyword(s):  
Cardiovascular Mortality ◽  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Albumin Excretion ◽  
Type 2 Diabetic ◽  
Overt Albuminuria

Urinary albumin excretion (UAE) is one of the strongest predictors of both adverse renal and cardiovascular outcomes in patients with type 2 diabetes. Although measurement of UAE is widely recommended, there is little available data to suggest that reducing UAE translates into a reduction in cardiovascular mortality. We assessed whether an early reduction in UAE is associated with improved long-term cardiovascular mortality in hypertensive type 2 diabetic patients with normo, micro, or overt albuminuria at baseline. The study is a 10-year longitudinal analysis of a prospective, randomized study- the Appropriate Blood Pressure Control in Diabetes (ABCD) trial including 393 type 2 diabetic patients with hypertension. We evaluated the association between the change in UAE from baseline to 1-year with the incidence of all cause and cardiovascular mortality over a ten year period. Our results revealed that a reduction in log UAE achieved at one-year was one of the strongest predictors of reduced cardiovascular mortality in a multivariable model that adjusted for multiple cardiovascular risk factors (HR1.42, 95% CI 1.06 – 1.92). This association was at all levels of UAE, normo, micro and overt albuminuria. In conclusion, an early reduction in UAE even at the normoalbuminuria level is associated with improvements in long-term cardiovascular mortality. Our data support current guideline recommendations to screen for UAE in all type 2 diabetic patients, but also suggest that serial UAE measurements after initiation of therapy may have clinical value. Prospective studies addressing this approach to care are needed prior to widespread adoption in practice.

scholarly journals Intravenous insulin decreases urinary albumin excretion in long-term diabetics with nephropathy

Diabetologia ◽  
1980 ◽  
Vol 18 (4) ◽  
Author(s):  
N.J. Christensen ◽  
H.J.G. Gundersen ◽  
C.E. Mogensen ◽  
E. Vittinghus
Keyword(s):  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Albumin Excretion ◽  
Intravenous Insulin
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