Factors influencing control of arterial circulation in the liver of the dog

1963 ◽  
Vol 205 (6) ◽  
pp. 1260-1264 ◽  
Author(s):  
Roy Cohn ◽  
Samuel Kountz
Keyword(s):  
Blood Flow ◽  
Hepatic Artery ◽  
Artery Blood Flow ◽  
Portal Venous Flow ◽  
Hepatic Arterial Flow ◽  
Experimental Conditions ◽  
Venous Flow ◽  
Arterial Circulation ◽  
Factors Influencing ◽  
Intrinsic Regulation

Measurements were made of the hepatic arterial flow in thirty-one mongrel dogs by the use of the electromagnetic square wave flowmeter under the following experimental conditions: hepatic arterial neurectomy, portal venous flow reductions, portal venous flow elimination and diversion, and systemic acidosis and alkalosis. The findings suggest that the periarterial nerves about the hepatic artery influence the intrinsic regulation of hepatic artery blood flow only in the presence of severely reduced portal venous flow.

scholarly journals Changes in Hepatic Hemodynamics due to Primary Liver Tumours

HPB Surgery ◽  
1996 ◽  
Vol 9 (4) ◽  
pp. 245-248 ◽  
Author(s):  
F. Jakab ◽  
Z. Ráth ◽  
F. Schmal ◽  
P. Nagy ◽  
J. Faller
Keyword(s):  
Hepatocellular Carcinoma ◽  
Blood Flow ◽  
Hepatic Artery ◽  
Hepatic Blood Flow ◽  
Primary Hepatocellular Carcinoma ◽  
Portal Venous Flow ◽  
Venous Flow ◽  
Control Value ◽  
Early Results ◽  
Total Hepatic Blood Flow

Data regarding the afferent circulation of the liver in patients with primary hepatocellular carcinoma are controversial, we have carried out measurement of hepatic arterial and portal venous flow intraoperatively by transit time ultrasonic volume flowmetry. In patients with primary hepatocellular carcinoma the hepatic artery flow increased to 0.55±0.211 compared with the control value of 0.37±0.102 1/min. (p<0.01). The portal venous flow decreased from 0.61±0.212 l/min, to 0.47±l/min. p<0.01). Due to the opposite changes in the afferent circulation the total hepatic blood flow did not change significantly, compared with controls.The ratio of hepatic arterial flow to portal vein flow increased to 1.239±0.246 in patients with hepatocellular carcinoma, which is double of the control value (0.66±0.259 l/min). After resection this ratio did not change.The resection did not alter hepatic artery or portal venous flow significantly, although the total hepatic blood flow decreased significantly (p<0.01).On the basis of our early results it is possible that the ratio of the two circulations may be to deel measured with doppler ultrasound and provide diagnostic information.

Hepatic blood flow distribution: consideration of gravity, liver surface, and norepinephrine on regional heterogeneity

1993 ◽  
Vol 71 (2) ◽  
pp. 128-135 ◽  
Author(s):  
W. Wayne Lautt ◽  
Joshua Schafer ◽  
Dallas J. Legare
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Arterial Occlusion ◽  
Flow Distribution ◽  
Arterial Flow ◽  
Blood Flow Distribution ◽  
Hepatic Arterial Flow ◽  
Venous Flow ◽  
Core Samples

Blood flow distribution within the livers of cats and dogs was assessed using 15-μm microspheres injected into the hepatic artery and portal vein. Representative vertical core samples (n = 11–18) were taken from the thickest part of each liver. Heterogeneity was assessed in several ways. The difference in total flow to different lobes was greater in dogs than in cats, and in dogs, those lobes with highest portal venous flow had lowest hepatic arterial flow. Overall flow variance was very high in both species, with adjacent surface samples in a single lobe showing variance of 15–22% for both vessels. The ratio of highest to lowest flow within core samples averaged 2.1–3.4 for both vessels in both species. The hepatic arterial flow was highest to the surface 2 mm of the liver. Portal flow most often (31% of all samples) showed a pattern of highest flow to the top, graduating down to lowest flow to the bottom (dorsal side) of the vertical cores. However, this pattern appeared much more frequently in the most ventral liver lobes and very seldom in the lobes lying beneath the liver mass. Norepinephrine reduced heterogeneity. Hepatic arterial occlusion for 10 min produced minor and inconsistent reduction of heterogeneity. Rotating cats from back to front and again to back disrupted patterns of distribution but not in a way that could be interpreted as due to effects of gravity. Flow patterns changed with time. The heterogeneity of perfusion appears to be under dynamic and multiple interacting forces.Key words: blood flow distribution, blood flow heterogeneity, hepatic artery, portal vein, liver.

scholarly journals A New Method to Measure Portal Venous and Hepatic Arterial Blood Flow Patients Intraoperatively

HPB Surgery ◽  
1996 ◽  
Vol 9 (4) ◽  
pp. 239-243 ◽  
Author(s):  
F. Jakab ◽  
Z. Ráth ◽  
F. Schmal ◽  
P. Nagy ◽  
J. Faller
Keyword(s):  
Hepatic Artery ◽  
Arterial Flow ◽  
Arterial Blood Flow ◽  
Portal Venous Flow ◽  
Hepatic Arterial Flow ◽  
Venous Flow ◽  
Venous Circulation ◽  
Arterial Blood ◽  
Temporary Occlusion ◽  
Artery Flow

The intraoperative measurement of the afferent circulation of the liver, namely the hepatic artery flow and portal venous flow was carried out upon 14 anesthetized patients having carcinoma in the splanchnic area, mainly in the head of the pancreas by means of transit time ultrasonic volume flowmeter. The hepatic artery flow, portal venous flow and total hepatic flow were 0.377±0.10; 0.614±0.21; 0.992±0.276 l/min respectively.The ratio of hepatic arterical flow to portal venous flow was 0.66±0.259 There was a sharp, significant increase in hepatic arterial flow (29.8±6.1%, p<0,01) after the temporary occlusion of the portal vein, while the temporary occlusion of hepatic artery did not have any significant effect on portal venous circulation. The interaction between hepatic arterial flow and portal venous flow is a much disputed question, but according to the presented data here, it is unquestionable, that the decrease of portal venous flow immediately results a significant increase in hepatic artery circulation.

scholarly journals Intraoperative evaluation of the hepatic artery blood flow during pancreatoduodenectomy (HEPARFLOW Study)

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S305
Author(s):  
M. Al-Saeedi ◽  
L. Frank-Moldzio ◽  
M. Klauß ◽  
P. Mayer ◽  
T. Bruckner ◽  
...  
Keyword(s):  
Blood Flow ◽  
Hepatic Artery ◽  
Artery Blood Flow ◽  
Intraoperative Evaluation

Recovery of blood flow and oxygen transport after temporary ischemia of rat liver

1998 ◽  
Vol 275 (1) ◽  
pp. H243-H249 ◽  
Author(s):  
Hiromu Kazuo ◽  
Toshirou Nishida ◽  
Akitoshi Seiyama ◽  
Shigeyuki Ueshima ◽  
Eisaku Hamada ◽  
...  
Keyword(s):  
Blood Flow ◽  
Hepatic Artery ◽  
Hepatic Blood Flow ◽  
Tissue Perfusion ◽  
Hepatic Tissue ◽  
Tissue Blood Flow ◽  
Initial Increase ◽  
Transport Parameters ◽  
Artery Ligation ◽  
Venous Flow

Hepatic tissue perfusion and O2 supply after ischemia are indispensable for recovery of cellular functions, but few studies have been performed regarding the recovery of tissue blood flow and O2 transport. After 5, 15, and 30 min of ischemia of rat livers, hepatic tissue perfusion, hepatic arterial and portal blood flow, plasma[Formula: see text], and O2 transport parameters were measured. Hepatic tissue blood flow and erythrocyte velocity in the sinusoids showed biphasic recoveries after temporal ischemia for 5, 15, and 30 min. The first peak in the flow appeared at 3–4 min after the initiation of tissue perfusion, and the second peak appeared at ∼20 min, irrespective of the ischemic period. Hepatic blood flow during the initial increase contained relatively low O2-saturated blood compared with that in the second increase. Livers that had been subjected to a prior hepatic artery ligation only showed the first peak at ∼4 min. The first increase in hepatic blood flow corresponded to the peak in the portal venous flow, and the second increase corresponded to that of the hepatic artery. These results suggested that hepatic microcirculation after temporary hepatic ischemia showed biphasic recoveries because of different restoration patterns of the portal vein and hepatic artery.

Compensatory Hepatic Artery Blood Flow Increase Prevents Liver Injury During Modified Multivisceral Transplant Evisceration

2017 ◽  
Vol 101 ◽  
pp. S20
Author(s):  
Bernardo Ketzer ◽  
Rodrigo Vincenzi ◽  
Ana Maria M. Coelho ◽  
Kátia R. Leite ◽  
Flavio H. Galvao ◽  
...  
Keyword(s):  
Blood Flow ◽  
Liver Injury ◽  
Hepatic Artery ◽  
Artery Blood Flow ◽  
Blood Flow Increase

Intraoperative Hepatic Artery Blood Flow Predicts Early Hepatic Artery Thrombosis After Liver Transplantation

2012 ◽  
Vol 44 (7) ◽  
pp. 2078-2081 ◽  
Author(s):  
L.M. Marín-Gómez ◽  
C. Bernal-Bellido ◽  
J.M. Álamo-Martínez ◽  
F.M. Porras-López ◽  
G. Suárez-Artacho ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Blood Flow ◽  
Hepatic Artery ◽  
Hepatic Artery Thrombosis ◽  
Artery Blood Flow ◽  
Artery Thrombosis
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