Cardiac afferents play the dominant role in renal nerve inhibition elicited by volume expansion in the rabbit

1998 ◽  
Vol 274 (2) ◽  
pp. R383-R388 ◽  
Author(s):  
Emilio Badoer ◽  
Viatcheslav Moguilevski ◽  
Barry P. McGrath
Keyword(s):  
Sympathetic Nerve ◽  
Volume Expansion ◽  
Sympathetic Nerve Activity ◽  
Dominant Role ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Conscious Rabbit ◽  
Renal Sympathetic Nerve ◽  
Cardiac Afferents ◽  
Renal Sympathetic

In the rabbit, vagotomy combined with arterial baroreceptor denervation abolishes the renal sympathoinhibition elicited by volume expansion. However, the effect of removing cardiopulmonary afferents alone has not been investigated. The aim of the present study was to determine the role of the cardiac afferents in the renal sympathetic response elicited by volume expansion in the normal conscious rabbit. Four experimental groups were used in which rabbits were administered 1) volume expansion (Haemaccel, 1.9 ml/min for 60 min), 2) volume expansion + bolus intrapericardial procaine (20 mg) to block cardiac afferents, 3) volume expansion + intravenous procaine (20 mg bolus), and 4) intrapericardial procaine alone (20 mg bolus). Volume expansion did not significantly affect mean arterial pressure or heart rate but produced a profound fall in renal sympathetic nerve activity (∼50%). Intrapericardial procaine administered 30 min after the start of volume expansion markedly reversed the renal sympathoinhibition to within 20% of the pre-volume expansion level, an effect that wore off over 25 min. In contrast, intravenous procaine lowered renal sympathetic nerve activity slightly further. The results suggest that cardiac afferents play the dominant role in the renal sympathoinhibition in response to volume expansion in the normal conscious rabbit.

Effects of volume expansion on renal sympathetic nerve activity and cardiovascular and renal function in lambs

1992 ◽  
Vol 262 (4) ◽  
pp. R651-R658 ◽  
Author(s):  
F. G. Smith ◽  
J. M. Klinkefus ◽  
J. E. Robillard
Keyword(s):  
Renal Function ◽  
Sympathetic Nerve ◽  
Volume Expansion ◽  
Sympathetic Nerve Activity ◽  
Right Atrial ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Renal Sympathetic Nerve ◽  
Cardiopulmonary Baroreflex ◽  
Renal Sympathetic

To assess the cardiopulmonary baroreflex in the immature animal, effects of volume expansion on changes in right atrial pressure, renal sympathetic nerve activity, and renal function were measured in chronically instrumented newborn (4-8 days; n = 13) and older lambs (4-5 wk; n = 14). Studies were carried out for 30 min before and 2 h after volume expansion with 6% Dextran 70 (25 ml/kg). Right atrial pressure increased by 4.0 +/- 0.5 mmHg in newborns and by 8.8 +/- 0.6 mmHg in older lambs within 15 min of volume expansion (P less than 0.001). After volume expansion, heart rate decreased in newborns from 237 +/- 6 beats/min to a nadir of 211 +/- 7 beats/min 2 h later (P less than 0.001) but remained constant at control levels of 148 +/- 9 beats/min in older lambs. Maximal inhibition of renal sympathetic nerve activity was achieved at 15 min in older lambs (-50.1 +/- 7.5%) and at 60 min (-58.3 +/- 10.9%) in newborns in which there was a prolonged sympathoinhibition (P less than 0.001). There was also a significant diuretic response in both groups but a limited natriuretic response to volume expansion in newborns (P greater than 0.05) compared with older lambs (P less than 0.001). These data demonstrate the presence of the cardiopulmonary baroreflex in the first week of life in lambs. The sustained sympathoinhibition and bradycardia seen in response to volume expansion in newborns but not in older lambs support the hypothesis that the reflexes controlling arterial pressure and blood volume change with postnatal maturation.

High-NaCl diet reduces cardiac vagal afferent nerve response to volume expansion

1987 ◽  
Vol 252 (4) ◽  
pp. R687-R692
Author(s):  
G. F. Dibona ◽  
L. L. Sawin
Keyword(s):  
Sympathetic Nerve ◽  
Volume Expansion ◽  
Sympathetic Nerve Activity ◽  
Baroreceptor Reflex ◽  
Afferent Nerve ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Renal Sympathetic Nerve ◽  
Vagal Afferent ◽  
Renal Sympathetic

To localize the mechanism by which high dietary NaCl intake decreases the reflex inhibitory effects of intravenous volume expansion on efferent renal sympathetic nerve activity, experiments were performed in anesthetized normal rats prepared for separate examination of the afferent and efferent limbs of the cardiopulmonary baroreceptor reflex. When left ventricular end-diastolic pressure, an index of left heart filling pressure, was progressively increased by intravenous isotonic saline administration in sinoaortic-denervated rats, the increase in cardiac vagal afferent nerve activity was less in rats consuming high compared with normal dietary NaCl intake. During electrical stimulation of the central vagus nerve in sinoaortic-denervated rats, the decreases in efferent renal sympathetic nerve activity were similar in rats consuming high and normal dietary NaCl intake. Thus the effect of high dietary NaCl intake to decrease overall cardiopulmonary baroreceptor reflex gain during intravenous volume expansion is located in the afferent limb of the reflex arc.

Dietary Na, age, and baroreflex control of heart rate and renal sympathetic nerve activity in rats

1992 ◽  
Vol 262 (5) ◽  
pp. H1441-H1448 ◽  
Author(s):  
B. S. Huang ◽  
F. H. Leenen
Keyword(s):  
Heart Rate ◽  
Sympathetic Nerve ◽  
Volume Expansion ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Baroreflex Control ◽  
Renal Sympathetic Nerve Activity ◽  
Young Rats ◽  
Renal Sympathetic Nerve ◽  
Renal Sympathetic

Heart rate (HR) and renal sympathetic nerve activity (RSNA) responses to ramp changes in blood pressure (BP) by (de)pressor agents and to acute volume expansion were recorded in conscious young, mature, and old Wistar rats maintained for 4 wk on diets containing low, control, or high dietary Na. Both HR and RSNA responses to BP increases or decreases were attenuated on low-Na diet compared with control Na diet. On high-Na diet, HR responses to BP changes and RSNA responses to BP increases were also attenuated, but in contrast the excitatory response of RSNA to BP decreases was augmented. The inhibitory RSNA response, but not the HR response, to volume expansion was significantly attenuated in young rats on high-Na diet but not on low-Na diet. The effects of both low and high dietary Na on HR and RSNA responses were most marked in young rats, less in mature rats, and even less in old rats. These results indicate a discordance of high dietary Na-induced changes in HR vs. RSNA control by the arterial and cardiopulmonary baroreflex, which is suggestive of central mechanisms affected by dietary Na. The developing nervous system appears to be the most responsive to dietary Na.

Effects of l-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats

2002 ◽  
Vol 97 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Akira Niijima ◽  
Tomoko Okui ◽  
Yasuo Matsumura ◽  
Toshihiko Yamano ◽  
Nobuo Tsuruoka ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Renal Sympathetic Nerve ◽  
Salt Hypertension ◽  
Renal Sympathetic

Suppression of renal sympathetic nerve activity during portal vein infusion of hypertonic saline

1998 ◽  
Vol 274 (1) ◽  
pp. R97-R103 ◽  
Author(s):  
Yasuhiro Nishida ◽  
Isao Sugimoto ◽  
Hironobu Morita ◽  
Hiroshi Murakami ◽  
Hiroshi Hosomi ◽  
...  
Keyword(s):  
Portal Vein ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Area Postrema ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Renal Sympathetic Nerve ◽  
Venous Infusion ◽  
Portal Vein Infusion ◽  
Renal Sympathetic

Sodium ions absorbed from the intestine are postulated to act on the liver to reflexly suppress renal sympathetic nerve activity (RSNA), resulting in inhibition of sodium reabsorption in the kidney. To test the hypothesis that the renal sympathoinhibitory response to portal venous NaCl infusion involves an action of arginine vasopressin (AVP) at the area postrema, we examined the effects of portal venous infusion of hypertonic NaCl on RSNA before and after lesioning of the area postrema (APL) or after pretreatment with an AVP V1 receptor antagonist (AVPX). Rabbits were chronically instrumented with portal and femoral venous catheters, femoral arterial catheters, and renal nerve electrodes. Portal venous infusion of 9.0% NaCl (0.02, 0.05, 0.10, and 0.15 ml ⋅ kg−1 ⋅ min−1of 9.0% NaCl for 10 min) produced a dose-dependent suppression of RSNA (−12 ± 3, −34 ± 3, −62 ± 5, and 80 ± 2%, respectively) that was greater than that produced by femoral vein infusion of 9.0% NaCl (2 ± 3, −3 ± 2, −12 ± 4, and −33 ± 3%, respectively). The suppression of RSNA produced by portal vein infusion of 9.0% NaCl was partially reversed by pretreatment with AVPX (−9 ± 3, −20 ± 3, −41 ± 4, and −55 ± 4%, respectively) and by APL (−11 ± 2, −25 ± 2, −49 ± 3, and −59 ± 6%, respectively). There were no significant differences between the effects of AVPX and APL, and the effect of APL was not augmented by AVPX. These results indicate that the suppression of RSNA due to portal venous infusion of 9.0% NaCl involves an action of AVP via the area postrema.

scholarly journals Electroacupuncture and Moxibustion Decrease Renal Sympathetic Nerve Activity and Retard Progression of Renal Disease in Rats

2012 ◽  
Vol 35 (5) ◽  
pp. 355-364 ◽  
Author(s):  
Josne C. Paterno ◽  
Cássia T. Bergamaschi ◽  
Ruy R. Campos ◽  
Elisa M.S. Higa ◽  
Maria Fernanda Soares ◽  
...  
Keyword(s):  
Renal Disease ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Renal Sympathetic Nerve ◽  
Progression Of Renal Disease ◽  
Renal Sympathetic
Sign in / Sign up

Export Citation Format

Share Document