Role of Ano1 Ca2+-activated Cl− channels in generating urethral tone
Keyword(s):
Studies from rabbit show that anoctamin-1 (Ano1) channels expressed in urethral interstitial cells of Cajal (ICCs) serve as a source of depolarization for smooth muscle cells, increasing excitability and tone. However, the role of urethral Ano1 channels is unclear, owing to differences in the species examined and experimental approaches. We summarize findings from different species on the role of urethral ICC and Ano1 channels in urethral contractility and outline proposals for clarifying this topic using cell-specific optogenetic approaches.
1984 ◽
Vol 246
(3)
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pp. G305-G315
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2006 ◽
Vol 576
(3)
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pp. 695-705
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Keyword(s):
Keyword(s):
1990 ◽
Vol 68
(3)
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pp. 447-454
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2008 ◽
Vol 294
(2)
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pp. G372-G390
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2018 ◽
Vol 30
(6)
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pp. e13300
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1990 ◽
Vol 68
(11)
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pp. 1437-1446
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2002 ◽
Vol 538
(3)
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pp. 823-835
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