scholarly journals Common Input to Motor Units of Digit Flexors During Multi-Digit Grasping

2004 ◽  
Vol 92 (6) ◽  
pp. 3210-3220 ◽  
Author(s):  
Sara A. Winges ◽  
Marco Santello
Keyword(s):  
Motor Unit ◽  
Motor Units ◽  
Flexor Digitorum Profundus ◽  
Flexor Muscle ◽  
Common Input ◽  
Single Motor ◽  
Single Motor Units ◽  
Finger Forces ◽  
Middle Ring ◽  
High Level

The control of whole hand grasping relies on complex coordination of multiple forces. While many studies have characterized the coordination of finger forces and torques, the control of hand muscle activity underlying multi-digit grasping has not been studied to the same extent. Motor-unit synchrony across finger muscles or muscle compartments might be one of the factors underlying the limited individuation of finger forces. Such “unwanted” coupling among finger forces, however, might be desirable when a high level of force coupling is required to prevent object slip during grasping. The goal of this study was to quantify the strength of synchrony between single motor units from extrinsic hand muscles as subjects held a device with a five-digit grasp. During the hold phase, we recorded the normal force exerted by each digit and the electrical activity of single motor units from each of the four divisions of the muscle flexor digitorum profundus (FDP) and one thumb flexor muscle, m. flexor pollicis longus (FPL). The strength of motor-unit synchrony was quantified by the common input strength index (CIS). We found moderate to strong motor-unit synchrony between FPL and the index FDP compartment [CIS: 0.49 ± 0.03 (SE)] and across most FDP compartments (0.34 ± 0.02). Weak synchrony, however, was found between FPL and the middle, ring, and little finger FDP compartments (0.25 ± 0.01). This difference might reflect the larger force contribution of the thumb-index finger pair relative to other thumb-finger combinations in five-digit grasping.

scholarly journals Periodic Modulation of Motor-Unit Activity in Extrinsic Hand Muscles During Multidigit Grasping

2005 ◽  
Vol 94 (1) ◽  
pp. 206-218 ◽  
Author(s):  
Jamie A. Johnston ◽  
Sara A. Winges ◽  
Marco Santello
Keyword(s):  
Motor Unit ◽  
Motor Units ◽  
Flexor Digitorum Profundus ◽  
Common Input ◽  
Hand Muscles ◽  
Single Motor Units ◽  
Flexor Digitorum ◽  
The Relationship ◽  
Muscle Coherence

We recently examined the extent to which motor units of digit flexor muscles receive common input during multidigit grasping. This task elicited moderate to strong motor-unit synchrony (common input strength, CIS) across muscles (flexor digitorum profundus, FDP, and flexor pollicis longus, FPL) and across FDP muscle compartments, although the strength of this common input was not uniform across digit pairs. To further characterize the neural mechanisms underlying the control of multidigit grasping, we analyzed the relationship between firing of single motor units from these hand muscles in the frequency domain by computing coherence. We report three primary findings. First, in contrast to what has been reported in intrinsic hand muscles, motor units belonging to different muscles and muscle compartments of extrinsic digit flexors exhibited significant coherence in the 0- to 5- and 5- to 10-Hz frequency ranges and much weaker coherence in the higher 10–20 Hz range (maximum 0.0025 and 0.0008, respectively, pooled across all FDP compartment pairs). Second, the strength and incidence of coherence differed considerably across digit pairs. Third, contrary to what has been reported in the literature, across-muscle coherence can be stronger and more prevalent than within-muscle coherence, as FPL–FDP2 (thumb-index digit pair) exhibited the strongest and most prevalent coherence in our data (0.010 and 43% at 3 Hz, respectively). The heterogeneous organization of common input to these muscles and muscle compartments is discussed in relation to the functional role of individual digit pairs in the coordination of multiple digit forces in grasping.

scholarly journals Muscle-Pair Specific Distribution and Grip-Type Modulation of Neural Common Input to Extrinsic Digit Flexors

2006 ◽  
Vol 96 (3) ◽  
pp. 1258-1266 ◽  
Author(s):  
Sara A. Winges ◽  
Jamie A. Johnston ◽  
Marco Santello
Keyword(s):  
Motor Units ◽  
Middle Finger ◽  
Flexor Digitorum Profundus ◽  
Flexor Muscle ◽  
Common Input ◽  
Single Motor Units ◽  
Specific Distribution ◽  
Neural Input ◽  
Muscle Pair ◽  
Flexor Digitorum

To gain insight into the synergistic control of hand muscles, we have recently quantified the strength of correlated neural activity across motor units from extrinsic digit flexors during a five-digit object-hold task. We found stronger synchrony and coherence across motor units from thumb and index finger flexor muscle compartment than between the thumb flexor and other finger flexor muscle compartments. The present study of two-digit object hold was designed to determine the extent to which such distribution of common input among thumb-finger flexor muscle compartments, revealed by holding an object with five digits, is preserved when varying the functional role of a given digit pair. We recorded normal force exerted by the digits and electrical activity of single motor units from muscle flexor pollicis longus (FPL) and two compartments of the m. flexor digitorum profundus (FDP2 and FDP3; index and middle finger, respectively). Consistent with our previous results from five-digit grasping, synchrony and coherence across motor units from FPL-FDP2 was significantly stronger than in FPL-FDP3 during object hold with two digits [common input strength: 0.49 ± 0.02 and 0.35 ± 0.02 (means ± SE), respectively; peak coherence: 0.0054 and 0.0038, respectively]. This suggests that the distribution of common neural input is muscle-pair specific regardless of grip type. However, the strength of coherence, but not synchrony, was significantly stronger in two- versus five-digit object hold for both muscle combinations, suggesting the periodicity of common input is sensitive to grip type.

Rectification is required to extract oscillatory envelope modulation from surface electromyographic signals

2014 ◽  
Vol 112 (7) ◽  
pp. 1685-1691 ◽  
Author(s):  
Christopher J. Dakin ◽  
Brian H. Dalton ◽  
Billy L. Luu ◽  
Jean-Sébastien Blouin
Keyword(s):  
Motor Unit ◽  
Stimulus Frequency ◽  
Motor Units ◽  
Surface Emg ◽  
Medial Gastrocnemius ◽  
Single Motor Unit ◽  
Single Motor ◽  
Single Motor Units ◽  
Emg Signal ◽  
Envelope Modulation

Rectification of surface electromyographic (EMG) recordings prior to their correlation with other signals is a widely used form of preprocessing. Recently this practice has come into question, elevating the subject of EMG rectification to a topic of much debate. Proponents for rectifying suggest it accentuates the EMG spike timing information, whereas opponents indicate it is unnecessary and its nonlinear distortion of data is potentially destructive. Here we examine the necessity of rectification on the extraction of muscle responses, but for the first time using a known oscillatory input to the muscle in the form of electrical vestibular stimulation. Participants were exposed to sinusoidal vestibular stimuli while surface and intramuscular EMG were recorded from the left medial gastrocnemius. We compared the unrectified and rectified surface EMG to single motor units to determine which method best identified stimulus-EMG coherence and phase at the single-motor unit level. Surface EMG modulation at the stimulus frequency was obvious in the unrectified surface EMG. However, this modulation was not identified by the fast Fourier transform, and therefore stimulus coherence with the unrectified EMG signal failed to capture this covariance. Both the rectified surface EMG and single motor units displayed significant coherence over the entire stimulus bandwidth (1–20 Hz). Furthermore, the stimulus-phase relationship for the rectified EMG and motor units shared a moderate correlation ( r = 0.56). These data indicate that rectification of surface EMG is a necessary step to extract EMG envelope modulation due to motor unit entrainment to a known stimulus.

Velocity of shortening of single motor units from rat soleus

1992 ◽  
Vol 67 (5) ◽  
pp. 1133-1145 ◽  
Author(s):  
S. R. Devasahayam ◽  
T. G. Sandercock
Keyword(s):  
Motor Unit ◽  
Motor Units ◽  
Surrounding Tissue ◽  
Passive Tension ◽  
Contraction Time ◽  
Single Motor ◽  
Twitch Contraction ◽  
Single Motor Units ◽  
Velocity Of Shortening ◽  
Force Velocity

1. The force-velocity relationship of a motor unit can provide insight into the contractile proteins of its constituent fibers as well as fundamental information about the function and use of the motor unit. Although the force-velocity profiles of whole muscle and skinned mammalian fibers have been studied, technical difficulties have prevented similar studies on motor units. A technique is presented to directly measure the velocity of shortening of individual motor units from in vivo rat soleus muscle. 2. The soleus muscles of anesthetized rats were dissected free of surrounding tissue while their nerve and blood supplies were preserved. Both tendons were cut, and the distal tendon was attached to a servomechanism to control muscle length, whereas the proximal tendon was attached to a force transducer. Single motor units were stimulated via the ventral roots. 3. The major problem encountered in measuring the force-velocity profile of a motor unit was that the force from the large number of passive fibers and connective tissue in the soleus confounded the force produced by the small number of active fibers in the motor unit. This problem was minimized by measuring active motor unit tension during an isovelocity ramp. This allowed experimental measurement of the passive tension by shortening the muscle with an identical isovelocity ramp without, however, stimulating the motor unit. Active tension was estimated by subtracting the passive tension waveform from the waveform recorded when the motor unit was active. 4. The method substantially reduced the noise from the passive fibers; however, problems remained. The probable sources of error are discussed, with the most significant being the elasticity associated with the blood and nerve connections to surrounding tissue. The elasticity prevents uniform shortening velocities along the length of the active fibers, thereby introducing a systematic bias to measurements made at high velocities. These errors are most pronounced when the data are extrapolated to determine the maximum velocity of shortening (Vmax). Determination of velocity at peak power (Vpp) is a more robust measure; however, of the 34 motor units studied, only 19 exhibited a distinct peak in the power-force curve, indicating residual noise. 5. To assess the validity of using twitch contraction time as an index of the velocity of shortening, when possible, Vmax and Vpp of each motor unit were correlated with the inverse of its twitch contraction time. The correlation was poor (r less than 0.2), indicating that, although widely used, twitch contraction time is a poor index of contractile speed.

Organization of single motor units in feline sartorius

1994 ◽  
Vol 72 (4) ◽  
pp. 1885-1896 ◽  
Author(s):  
E. Smits ◽  
P. K. Rose ◽  
T. Gordon ◽  
F. J. Richmond
Keyword(s):  
Motor Unit ◽  
Cross Section ◽  
Cross Sections ◽  
Muscle Fibers ◽  
Motor Units ◽  
Single Motor Unit ◽  
Single Motor ◽  
Medial Head ◽  
Single Motor Units ◽  
Fast Twitch

1. We depleted single motor units in feline sartorius muscles of glycogen by stimulating their motoneurons intracellularly. We mapped the intramuscular distribution of depleted fibers by inspecting histological cross-sections throughout the length of sartorius. 2. We selected ten depleted motor units for detailed study and quantitative analysis. Nine motor units were located in the anterior head of sartorius. One was located in a muscle whose distal half appeared to have been damaged some time before the acute experiment. A single motor unit was located in the medial head of sartorius. 3. Five motor units were composed of fast-twitch glycolytic (FG) muscle fibers, two of fast-twitch oxidative glycolytic (FOG) muscle fibers, and three of slow-twitch oxidative (SO) muscle fibers. Estimates of the numbers of depleted fibers in motor units of anterior sartorius indicated that FG motor units were larger (mean 566 fibers) than FOG and SO motor units (SO mean 190, FOG mean 156 fibers). The SO motor unit in the damaged muscle had 550 fibers. One motor unit depleted in the medial head of sartorius had 270 fibers with FG profiles. 4. Muscle fibers belonging to each anterior motor unit were never distributed throughout the whole cross-section of anterior sartorius at any proximodistal level. Furthermore, fibers were distributed nonuniformly along the proximodistal axis of the muscle. In most muscles at least a few depleted fibers were found at all proximodistal levels. However, in one normal muscle and the damaged muscle, depleted fibers were confined to the proximal end. 5. The fibers in the medial motor unit were confined to a strip that did not extend across the whole cross-section of the muscle head. Fibers within this strip were scattered quite evenly from origin to insertion. This medial FG motor unit occupied a smaller territory and contained fewer fibers than anterior motor units of the same histochemical type. 6. These results show that sartorius motor units are not distributed uniformly in the mediolateral plane; those in anterior sartorius were distributed asymmetrically in the proximodistal axis as well. This finding has important functional implications for the way in which we model force development and transmission in sartorius and other long muscles.

Behavior of motor units in human biceps brachii during a submaximal fatiguing contraction

1994 ◽  
Vol 76 (6) ◽  
pp. 2411-2419 ◽  
Author(s):  
S. J. Garland ◽  
R. M. Enoka ◽  
L. P. Serrano ◽  
G. A. Robinson
Keyword(s):  
Motor Unit ◽  
Biceps Brachii ◽  
Discharge Rate ◽  
Human Subjects ◽  
Absolute Threshold ◽  
Motor Units ◽  
Single Motor ◽  
Threshold Force ◽  
Single Motor Units ◽  
Discharge Rates

The activity of 50 single motor units was recorded in the biceps brachii muscle of human subjects while they performed submaximal isometric elbow flexion contractions that were sustained to induce fatigue. The purposes of this study were to examine the influence of fatigue on motor unit threshold force and to determine the relationship between the threshold force of recruitment and the initial interimpulse interval on the discharge rates of single motor units during a fatiguing contraction. The discharge rate of most motor units that were active from the beginning of the contraction declined during the fatiguing contraction, whereas the discharge rates of most newly recruited units were either constant or increased slightly. The absolute threshold forces of recruitment and derecruitment decreased, and the variability of interimpulse intervals increased after the fatigue task. The change in motor unit discharge rate during the fatigue task was related to the initial rate, but the direction of the change in discharge rate could not be predicted from the threshold force of recruitment or the variability in the interimpulse intervals. The discharge rate of most motor units declined despite an increase in the excitatory drive to the motoneuron pool during the fatigue task.

Single motor unit activity in the diaphragm of cat during pressure breathing

1981 ◽  
Vol 50 (2) ◽  
pp. 348-357 ◽  
Author(s):  
B. Bishop ◽  
S. Settle ◽  
J. Hirsch
Keyword(s):  
Motor Unit ◽  
Negative Pressure ◽  
Motor Units ◽  
Positive Pressure ◽  
Quiet Breathing ◽  
Single Motor Unit ◽  
Single Motor ◽  
Single Motor Units ◽  
Negative Pressure Breathing ◽  
Phrenic Motoneuron

In this study we analyzed the breath-by-breath activity of single motor units in the diaphragm slip of allobarbital-anesthetized cats during quiet breathing and during continuous positive- and negative-pressure breathing. Our objective was to determine whether single motor units, on the basis of their activities, can be separated into discrete subpopulations or whether they fall on a continuum analogous to that of motor units of hindlimb muscles. The firing profiles of each unit were characterized for each pressure level by the onset and peak firing frequencies, onset latency, duration of firing, number of impulses per breath, and minimal frequency, when appropriate. Units with shorter onset latencies had higher peak frequencies, longer firing durations, and increased firing frequencies than did units with longer onset latencies. These comparative relationships persisted even though the activity of every motor unit was altered during pressure breathing. During positive-pressure breathing onset latencies were lengthened, and durations of firing were shortened with little change in onset or peak frequencies. Late units might be silenced. During negative-pressure breathing onset latencies were shortened, and durations of firing were lengthened, sufficiently in some cases to fill the expiratory pause. In addition, previously inactive units were recruited late in inspiration for short, relatively high frequency bursts during inspiration. The results support the concept that the phrenic motoneuron pool is comprised of three discrete subpopulations.

scholarly journals Discharge frequencies of single motor units in human diaphragm and parasternal muscles in lying and standing

2001 ◽  
Vol 90 (1) ◽  
pp. 147-154 ◽  
Author(s):  
J. E. Butler ◽  
D. K. McKenzie ◽  
S. C. Gandevia
Keyword(s):  
Tidal Volume ◽  
Motor Unit ◽  
Motor Units ◽  
Neural Drive ◽  
Unit Discharge ◽  
Single Motor Unit ◽  
Single Motor ◽  
Single Motor Units ◽  
Inspiratory Muscles ◽  
Motor Unit Discharge

Single motor unit discharge was measured directly in diaphragm and parasternal intercostal muscles to determine whether neural drive to human inspiratory muscles changes between lying and standing. The final discharge frequency of diaphragmatic motor units increased slightly, by 1 Hz (12%; P < 0.01), when subjects were standing [182 units, median 9.1 Hz (interquartile range 7.6–11.3 Hz)] compared with lying supine [159 units, 8.1 Hz (6.6–10.3 Hz)]. However, this increase with standing occurred in only two of six subjects, in one of whom tidal volume increased significantly during standing. Parasternal intercostal motor unit final discharge frequencies did not differ between standing [116 units, 8.0 Hz (6.6–9.6 Hz)] and lying [124 units, 8.4 Hz (7.0–10.3 Hz)]. The discharge frequencies at the onset of inspiration did not differ between lying and standing for either muscle. A larger proportion of motor units in both inspiratory muscles had postinspiratory or tonic expiratory activity for lying compared with standing (15 vs. 4%; P < 0.05). We conclude that there is no major difference in the phasic inspiratory drive to the diaphragm with the change in posture.

Reduced motor unit activation of muscle spindles and tendon organs in the immobilized cat hindlimb

1995 ◽  
Vol 78 (3) ◽  
pp. 901-913 ◽  
Author(s):  
M. A. Nordstrom ◽  
R. M. Enoka ◽  
R. M. Reinking ◽  
R. C. Callister ◽  
D. G. Stuart
Keyword(s):  
Motor Unit ◽  
Motor Units ◽  
Muscle Spindles ◽  
Tibialis Posterior ◽  
Fiber Types ◽  
Single Motor Unit ◽  
Tetanic Force ◽  
Single Motor ◽  
Single Motor Units ◽  
Tendon Organs

Six weeks of limb immobilization of a healthy muscle (cat tibialis posterior) at a short length resulted in a significant reduction of mean fiber area for all fiber types (I, 71% of control; IIa, 77% of control; IIb, 79% of control), whereas fiber type proportions were unchanged. For motor units, there was a reduction in peak tetanic force (type slow > fast fatigue resistant > fast fatigable); an increase in the twitch-to-tetanus ratio for fast fatigue-resistant and slow units; and no effect on the twitch force, twitch time course, or fatigability. The reduction in peak force was greater than expected because of fiber atrophy in slow units. Immobilization had a minimal effect on muscle spindle afferent (Ia and spindle group II) responses to a ramp-and-hold stretch of the passive muscle. Tendon organ (Ib) afferents had an increased responsiveness to stretch after immobilization but only when the muscle was stretched from a short resting length. However, immobilization reduced the modulation of muscle afferent discharge in response to tetanic contractions of single motor units. The decline in responsiveness of spindles was a result of the reduced tetanic force of motor units. In contrast, tendon organs in immobilized muscle were twice as likely to convey no information on the contraction of a single motor unit and were more likely to be unloaded, suggesting that immobilization caused the functional denervation of some muscle fibers. Thus the responses of muscle spindles and tendon organs in immobilized muscle reflected atrophic changes in extrafusal fibers but did not provide evidence for substantial disturbance of receptor function.

Changes in Voice Fundamental Frequency Following Discharge of Single Motor Units in Cricothyroid and Thyroarytenoid Muscles

1987 ◽  
Vol 30 (4) ◽  
pp. 552-558 ◽  
Author(s):  
Charles R. Larson ◽  
Gail B. Kempster ◽  
Michael K. Kistler
Keyword(s):  
Motor Unit ◽  
Averaging Method ◽  
Motor Units ◽  
Vocal Folds ◽  
Single Motor Unit ◽  
Single Motor ◽  
Cricothyroid Muscle ◽  
Single Motor Units ◽  
Contraction Times ◽  
Voice Fundamental Frequency

This investigation was designed to measure voice F 0 changes related to single motor unit (SMU) contractions in the cricothyroid and thyroarytenoid muscles. Four subjects (3 men and 1 woman) were recorded producing a prolonged vowel at modal pitch and loudness levels while simultaneous recordings of electromyograms (EMG) from the muscles were obtained. Voice F 0 changes unrelated to SMU firings in the muscles were eliminated using an averaging method previously described by Baer (1979). Results indicate that the time between discharge of the SMU and the peak in F 0 Change ("F 0 Latency") was variable and ranged from 5 to 20 ms for the thyroarytenoid and 6 to 75 ms for the cricothyroid muscle. Distinct oscillations in F 0 were always present in recordings from the woman subject and from the men when they phonated at higher-than-modal pitch levels. The findings are discussed in relation to SMU contraction times, biomechanics of the vocal folds, and the presence of jitter in normal voices.

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