Developmental plasticity of descending motor pathways

2011 ◽  
Vol 105 (5) ◽  
pp. 1963-1965 ◽  
Author(s):  
Hsiu-Ling Li ◽  
Curtis O. Asante
Keyword(s):  
Functional Recovery ◽  
Developmental Plasticity ◽  
Juvenile Rats ◽  
Motor Pathways ◽  
Juvenile Animal ◽  
Spinal Pathway ◽  
Fast Excitation

Juvenile animal brains are highly plastic and thus often achieve better functional recovery after injury compared with adult brains. Recently, Umeda et al. (Umeda T, Takahashi M, Isa K, Isa T. J Neurophysiol 104: 1707–1716, 2010) have shown that the remodeling of both corticospinal and extra-pyramidal pathways can contribute to the recovery of grasping and reaching ability in hemidecorticated juvenile rats. They have further unveiled the strengthening of the cortico-reticulo-spinal pathway after injury, that mediates the fast excitation of ipsilateral motoneurons for functional recovery.

Renal tubular sites of increased phosphate transport and NaPi-2 expression in the juvenile rat

2001 ◽  
Vol 280 (5) ◽  
pp. R1524-R1533 ◽  
Author(s):  
Craig Woda ◽  
Susan E. Mulroney ◽  
Nabil Halaihel ◽  
Lijun Sun ◽  
Paul V. Wilson ◽  
...  
Keyword(s):  
Brush Border Membrane ◽  
Immunofluorescence Microscopy ◽  
Phosphate Transport ◽  
Adult Rats ◽  
Juvenile Rats ◽  
Juvenile Animal ◽  
Male Wistar Rats ◽  
Proximal Tubular ◽  
Renal Micropuncture ◽  
Renal Tubular

To determine the tubular sites and mechanisms involved in enhanced renal phosphate (Pi) reabsorption seen in the juvenile animal, renal micropuncture experiments were performed in acutely thyroparathyroidectomized adult (>14 wk old) and juvenile (4 wk old) male Wistar rats fed either a normal Pi diet (NPD, 0.6% Pi) or low Pi diet (0.07% Pi) for 2 days, in the presence and absence of parathyroid hormone (PTH). Pi reabsorption was greater in proximal convoluted (PCT) and straight tubules (PST) of the juvenile compared with adult rats fed NPD, whether or not PTH was present. These findings were consistent with a greater Piuptake in brush-border membrane (BBM) vesicles from both superficial (SC) and outer juxtamedullary (JMC) cortices of juvenile animals. Western blot analysis revealed a 2- and 1.8-fold higher amount of NaPi-2 protein in the SC and JMC, respectively, in juvenile rats. Immunofluorescence microscopy also indicated that NaPi-2 protein expression was present in the proximal tubule (PT) BBM to a greater extent in juvenile rats. Dietary Pi restriction in juvenile rats resulted in a significant increase in Pi reabsorption in the PCT and PST segments. NaPi-2 expression in the PT BBM was also increased, as was the expression of intracellular NaPi-2 protein. These studies indicate that Pi reabsorption in both the PCT and PST segments of the renal tubule contributes to the attenuated response to PTH in the normal juvenile animal. In addition, dietary Pi restriction in the juvenile rat upregulates BBM NaPi-2 expression, which is associated with a further increase in proximal tubular Pi reabsorption.

Post-acute delivery of α5-GABAA antagonist, S 44819, improves functional recovery in juvenile rats following stroke

2021 ◽  
pp. 113881
Author(s):  
Florent Lebrun ◽  
Nicolas Violle ◽  
Annelise Letourneur ◽  
Christophe Muller ◽  
Nicolas Fischer ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Juvenile Rats ◽  
Gabaa Antagonist

Cardiomyocyte-specific overexpression of type 5 phosphodiesterase impairs functional recovery after myocardial infarction

2008 ◽  
Vol 7 ◽  
pp. 206-206
Author(s):  
P POKREISZ ◽  
A VANDENBERGH ◽  
V BITO ◽  
G MARSBOOM ◽  
S VANDENWIJNGAERT ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Functional Recovery

Obesity Is Associated With Poorer Functional Recovery Following Knee Surgery

2007 ◽  
Author(s):  
Patricia H. Rosenberger ◽  
Robert D. Kerns ◽  
Peter Jokl ◽  
Jeannette R. Ickovics
Keyword(s):  
Functional Recovery ◽  
Knee Surgery

Overweight induced by hypernutrition in juvenile rats dysregulates the central monoamines in the adult age.

2020 ◽  
Author(s):  
Maria Martha Bernardi ◽  
Daclé Juliane Macrini ◽  
Paula da Silva Rodrigues ◽  
Thiago Berti Kirsten ◽  
Gabriela Pena Chaves-Kirsten ◽  
...  
Keyword(s):  
Juvenile Rats ◽  
Adult Age
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