Themes and Variations in ER/SR Calcium Release Channels: Structure and Function

Physiology ◽  
2012 ◽  
Vol 27 (6) ◽  
pp. 331-342 ◽  
Author(s):  
Peter B. Stathopulos ◽  
Min-duk Seo ◽  
Masahiro Enomoto ◽  
Fernando J. Amador ◽  
Noboru Ishiyama ◽  
...  
Keyword(s):  
Calcium Release ◽  
Common Ancestor ◽  
Structural Data ◽  
Structure And Function ◽  
Release Channel ◽  
Calcium Release Channels ◽  
Channel Function ◽  
Regulatory Signal ◽  
And Function ◽  
Sr Calcium Release

Calcium (Ca2+) release from reticular stores is a vital regulatory signal in eukaryotes. Recent structural data on large NH2-terminal regions of IP3Rs and RyRs and their tetrameric arrangement in the full-length context reveal striking mechanistic similarities in Ca2+ release channel function. A common ancestor found in unicellular genomes underscores the fundamentality of these elements to Ca2+ release channels.

scholarly journals β-Adrenergic Receptor Blockers Restore Cardiac Calcium Release Channel (Ryanodine Receptor) Structure and Function in Heart Failure

Circulation ◽  
2001 ◽  
Vol 104 (23) ◽  
pp. 2843-2848 ◽  
Author(s):  
Steven Reiken ◽  
Marta Gaburjakova ◽  
Jana Gaburjakova ◽  
Kun-lun He ◽  
Alfonso Prieto ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ryanodine Receptor ◽  
Adrenergic Receptor ◽  
Calcium Release ◽  
Structure And Function ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Receptor Structure ◽  
Receptor Blockers ◽  
And Function

scholarly journals Themes and Variations in Endoplasmic Reticulum Calcium Release Channels: Structure and Function

2012 ◽  
Vol 52 (6) ◽  
pp. 266-271
Author(s):  
Masahiro Enomoto ◽  
Noboru Ishiyama ◽  
Min-Duk Seo ◽  
Fernando J. Amador ◽  
Peter B. Stathopulos ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Calcium Release ◽  
Structure And Function ◽  
Calcium Release Channels ◽  
Endoplasmic Reticulum Calcium ◽  
And Function

scholarly journals Simultaneous TE Analysis of 19 Heliconiine Butterflies Yields Novel Insights into Rapid TE-Based Genome Diversification and Multiple SINE Births and Deaths

2019 ◽  
Vol 11 (8) ◽  
pp. 2162-2177 ◽  
Author(s):  
David A Ray ◽  
Jenna R Grimshaw ◽  
Michaela K Halsey ◽  
Jennifer M Korstian ◽  
Austin B Osmanski ◽  
...  
Keyword(s):  
Transposable Elements ◽  
Common Ancestor ◽  
Genome Structure ◽  
Detailed Examination ◽  
Structure And Function ◽  
Evolutionary Processes ◽  
Repetitive Nature ◽  
Daunting Task ◽  
And Function

Abstract Transposable elements (TEs) play major roles in the evolution of genome structure and function. However, because of their repetitive nature, they are difficult to annotate and discovering the specific roles they may play in a lineage can be a daunting task. Heliconiine butterflies are models for the study of multiple evolutionary processes including phenotype evolution and hybridization. We attempted to determine how TEs may play a role in the diversification of genomes within this clade by performing a detailed examination of TE content and accumulation in 19 species whose genomes were recently sequenced. We found that TE content has diverged substantially and rapidly in the time since several subclades shared a common ancestor with each lineage harboring a unique TE repertoire. Several novel SINE lineages have been established that are restricted to a subset of species. Furthermore, the previously described SINE, Metulj, appears to have gone extinct in two subclades while expanding to significant numbers in others. This diversity in TE content and activity has the potential to impact how heliconiine butterflies continue to evolve and diverge.

Calcium-sensitivity of the SR calcium release channel in failing and nonfailing human myocardium

1999 ◽  
Vol 94 (3) ◽  
pp. 145-151 ◽  
Author(s):  
U. Schotten ◽  
C. Schumacher ◽  
V. Conrads ◽  
V. Braun ◽  
F. Schöndube ◽  
...  
Keyword(s):  
Calcium Release ◽  
Calcium Sensitivity ◽  
Human Myocardium ◽  
Calcium Release Channel ◽  
Release Channel ◽  
Sr Calcium Release
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