sr calcium release
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scholarly journals Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve

2020 ◽  
Vol 319 (5) ◽  
pp. H1021-H1035
Author(s):  
Elisabeth DiNello ◽  
Elisa Bovo ◽  
Paula Thuo ◽  
Thomas G. Martin ◽  
Jonathan A. Kirk ◽  
...  
Keyword(s):  
Calcium Release ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Channel ◽  
Adult Onset ◽  
Cardiac Dyssynchrony ◽  
Intracellular Calcium Signaling ◽  
Transient Receptor ◽  
Sr Calcium Release

Our goal was to characterize the role of the transient receptor potential channel polycystin 2 (PC2) in cardiomyocytes following adult-onset deletion. Loss of PC2 resulted in decreased cardiac shortening and cardiac dyssynchrony and diminished adrenergic reserve. These results suggest that cardiac-specific PC2 modulates intracellular calcium signaling and contributes to the maintenance of adrenergic pathways.

scholarly journals Mathematical Model to Simulate Sr Calcium Release in Mammalian Skeletal Muscle with Impaired T-Tubular Structure

2019 ◽  
Vol 116 (3) ◽  
pp. 522a-523a
Author(s):  
Vincent Jacquemond ◽  
Peter Szentesi ◽  
Candice Kutchukian ◽  
Beatrix Dienes ◽  
Laszlo Csernoch
Keyword(s):  
Mathematical Model ◽  
Skeletal Muscle ◽  
Calcium Release ◽  
Tubular Structure ◽  
Mammalian Skeletal Muscle ◽  
Sr Calcium Release

scholarly journals Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

10.3791/55822 ◽  
2017 ◽  
Author(s):  
Florence N. Reddish ◽  
Cassandra L. Miller ◽  
Rakshya Gorkhali ◽  
Jenny J. Yang
Keyword(s):  
Calcium Release ◽  
Sr Calcium Release

scholarly journals Mg 2+ Inhibits Cardiac SR Calcium Release and has Biphasic Effects on Calmodulin Binding to RyR2

2017 ◽  
Vol 112 (3) ◽  
pp. 255a
Author(s):  
Xiaoqiong Dong ◽  
Ivanita Stefanon ◽  
Rogerio F. Ribeiro ◽  
Mena Said ◽  
Robyn T. Rebbeck ◽  
...  
Keyword(s):  
Calcium Release ◽  
Calmodulin Binding ◽  
Sr Calcium Release

scholarly journals Mechanisms of SR calcium release in healthy and failing human hearts

2014 ◽  
Vol 7 (1) ◽  
pp. 33-41 ◽  
Author(s):  
K. Walweel ◽  
D. R. Laver
Keyword(s):  
Calcium Release ◽  
Sr Calcium Release

scholarly journals Non-Linear Relationship Between T-Tubule Remodeling and Sr Calcium Release in Failing Rat Ventricle

2014 ◽  
Vol 106 (2) ◽  
pp. 447a
Author(s):  
Jasleen Singh ◽  
Nikhil Bassi ◽  
Shannon Tai ◽  
Shruthi Mothkur ◽  
William Marszalec ◽  
...  
Keyword(s):  
Linear Relationship ◽  
Calcium Release ◽  
Non Linear ◽  
Rat Ventricle ◽  
Sr Calcium Release

Themes and Variations in ER/SR Calcium Release Channels: Structure and Function

Physiology ◽  
2012 ◽  
Vol 27 (6) ◽  
pp. 331-342 ◽  
Author(s):  
Peter B. Stathopulos ◽  
Min-duk Seo ◽  
Masahiro Enomoto ◽  
Fernando J. Amador ◽  
Noboru Ishiyama ◽  
...  
Keyword(s):  
Calcium Release ◽  
Common Ancestor ◽  
Structural Data ◽  
Structure And Function ◽  
Release Channel ◽  
Calcium Release Channels ◽  
Channel Function ◽  
Regulatory Signal ◽  
And Function ◽  
Sr Calcium Release

Calcium (Ca2+) release from reticular stores is a vital regulatory signal in eukaryotes. Recent structural data on large NH2-terminal regions of IP3Rs and RyRs and their tetrameric arrangement in the full-length context reveal striking mechanistic similarities in Ca2+ release channel function. A common ancestor found in unicellular genomes underscores the fundamentality of these elements to Ca2+ release channels.

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