Changes in Brain Blood Flow and Oxidative Metabolism During Mental Activity

Physiology ◽  
1987 ◽  
Vol 2 (4) ◽  
pp. 120-124 ◽  
Author(s):  
PE Roland
Keyword(s):  
Blood Flow ◽  
Oxidative Metabolism ◽  
Regional Cerebral Blood Flow ◽  
Mental Activity ◽  
Brain Blood Flow ◽  
Regional Cerebral Blood ◽  
Different Types ◽  
The Brain ◽  
Cerebral Oxidative Metabolism ◽  
Different Parts

Until recently mental activity was regarded as too subtle to have any effect on energy metabolism of the brain. Recent measurements show that when subjects perform pure mental activity regional cerebral oxidative metabolism and regional cerebral blood flow (which are dynamically coupled) increase in several areas of the brain, including the cerebellum. Different types of mental activity cause such increases in different parts of the brain.

Vorläufige Ergebnisse von 99mTc-HMPAO-SPECT-Untersuchungen bei endogenen Psychosen

1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Post Mortem ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
The Brain ◽  
99Mtc Hmpao

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

Regional cerebral blood flow response during and after acute asphyxia in newborn piglets

1989 ◽  
Vol 66 (6) ◽  
pp. 2827-2832 ◽  
Author(s):  
J. M. Goplerud ◽  
L. C. Wagerle ◽  
M. Delivoria-Papadopoulos
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Stem ◽  
Regional Cerebral Blood Flow ◽  
Muscle Blood Flow ◽  
Organ Blood Flow ◽  
Brain Blood Flow ◽  
Regional Cerebral Blood ◽  
Newborn Piglets ◽  
Total Brain

The hemodynamic response during and after acute asphyxia was studied in 14 newborn piglets. An apnea-like asphyxial insult was produced in paralyzed mechanically ventilated piglets by discontinuing ventilation until the piglets became bradycardic (heart rate less than 80 beats/min). Seven piglets had organ blood flow measured by microspheres at control, during asphyxia (PO2 = 16 +/- 11 Torr, pH = 7.31 +/- 0.07, PCO2 = 47 +/- 9 Torr), and during recovery from asphyxia. During acute asphyxia, rapid organ blood flow redistribution occurred, producing decreased renal and skeletal muscle blood flow, while coronary blood flow increased. Although total brain blood flow changed little during asphyxia, regional cerebral blood flow (rCBF) analysis revealed significant nonhomogeneous blood flow distribution within the brain during asphyxia, with decreases to the cerebral gray and white matter and the choroid plexus, whereas brain stem structures had increased flow. During recovery with reventilation, total brain blood flow increased 24% above control, with a more uniform distribution and increased flow to all brain regions. The time course of rCBF changes during acute asphyxia was then determined in seven additional piglets with CBF measurements made sequentially at 30–60 s, 60–120 s, and 120–180 s of asphyxia. The vasoconstriction seen in cortical structures, concurrent with the reduction in skeletal and kidney blood flow, known to be sympathetically mediated, suggest a selective reflex effect in this brain region. The more gradual and progressive vasodilation in brain stem regions during asphyxia is consistent with chemical control. These findings demonstrate significant regional heterogeneity in CBF regulation in newborn piglets.

Might Migraine Damage The Brain?

Cephalalgia ◽  
1994 ◽  
Vol 14 (6) ◽  
pp. 415-418 ◽  
Author(s):  
E Chronicle ◽  
W Mulleners
Keyword(s):  
Blood Flow ◽  
Migraine With Aura ◽  
Regional Cerebral Blood Flow ◽  
Neuronal Damage ◽  
Inhibitory Interneurons ◽  
Regional Cerebral Blood ◽  
Hypoxic Conditions ◽  
Recent Debate ◽  
The Brain

Recent debate concerning the interpretation of studies of regional cerebral blood flow in migraine has re-emphasized that cerebral ischaemia may occur during attacks of migraine with aura. In this article we suggest that the presence of ischaemia during attacks makes it possible that migraine with aura causes neuronal damage in the long term. We argue that damage is likely to occur in the primary visual cortex, given that a recent high-resolution rCBF study has found flow reductions confined to this area. Furthermore, we hypothesize that the extent to which rCBF is reduced in migraine with aura is sufficient to cause damage only to GABA-ergic inhibitory interneurons in layer IV of this cortex. In animal models, similar cells are known to be selectively vulnerable to damage as a result of hypoxic conditions. Evidence consistent with our hypothesis is provided by recent studies of visual function in migraine. Some clinical and pathophysiological implications of this hypothesis are discussed.

Personality and Regional Cerebral Blood Flow

1984 ◽  
Vol 144 (5) ◽  
pp. 529-532 ◽  
Author(s):  
Roy J. Mathew ◽  
Maxine L. Weinman ◽  
Deborah L. Barr
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Function ◽  
Regional Cerebral Blood Flow ◽  
Cortical Arousal ◽  
Regional Cerebral Blood ◽  
Capillary Perfusion ◽  
Brain Capillary ◽  
Eysenck Personality Inventory ◽  
The Brain

SummaryThe extraversion–introversion dimension of personality is believed to have an inverse relationship with cortical arousal. Brain capillary perfusion is a well established index of brain function and arousal. Regional cerebral blood flow was measured in 51 right-handed females whose personality structure was examined with the Eysenck Personality Inventory (EPI). Significant inverse correlations were found between the brain blood flow and the extraversion–introversion score of EPI.

The cerebellum participates in mental activity: tomographic measurements of regional cerebral blood flow

1990 ◽  
Vol 535 (2) ◽  
pp. 313-317 ◽  
Author(s):  
Jean Decety ◽  
Hans Sjo¨holm ◽  
Erik Ryding ◽  
Georg Stenberg ◽  
David H. Ingvar
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Mental Activity ◽  
Regional Cerebral Blood
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