scholarly journals Pulmonary Embolism Revealing Idiopathic Membranous Glomerulonephritis

2010 ◽  
Vol 2010 ◽  
pp. 1-3
Author(s):  
A. Hamzaoui ◽  
O. Harzallah ◽  
R. Klii ◽  
L. Njim ◽  
S. Mahjoub
Keyword(s):  
Pulmonary Embolism ◽  
Nephrotic Syndrome ◽  
Membranous Nephropathy ◽  
Membranous Glomerulonephritis ◽  
Idiopathic Membranous Nephropathy ◽  
Idiopathic Membranous Glomerulonephritis

We describe a case of a 55-year-old man who presented with pulmonary embolism and who was found to have nephrotic syndrome due to idiopathic membranous nephropathy. There are no other signs of nephrotic syndrome such as edema.

Effect of Prolonged Tacrolimus Treatment in Idiopathic Membranous Nephropathy with Nephrotic Syndrome

Pharmacology ◽  
2013 ◽  
Vol 91 (5-6) ◽  
pp. 259-266 ◽  
Author(s):  
Hang Yuan ◽  
Nian Liu ◽  
Guang-Dong Sun ◽  
Ye Jia ◽  
Ping Luo ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy

Dysbiosis of gut microbiota in adult idiopathic membranous nephropathy with nephrotic syndrome

2020 ◽  
Vol 147 ◽  
pp. 104359 ◽  
Author(s):  
Jun Zhang ◽  
Dan Luo ◽  
Zhiming Lin ◽  
Wenying Zhou ◽  
Jialing Rao ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gut Microbiota ◽  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy

Membranous glomerulonephritis

2018 ◽  
Author(s):  
Daniel C. Cattran ◽  
Heather N. Reich
Keyword(s):  
Nephrotic Syndrome ◽  
Hepatitis B ◽  
Renal Biopsy ◽  
Clinical Picture ◽  
Membranous Nephropathy ◽  
Membranous Glomerulonephritis ◽  
Hepatitis B Infection ◽  
Immunoglobulin G4 ◽  
Secondary Membranous Nephropathy ◽  
Secondary Causes

Membranous glomerulonephritis (MGN) usually presents as nephrotic syndrome, which may be severe. It is primarily a disease of adults, men more than women, with a peak incidence in the fourth and fifth decades. It is hoped that proven tests for the characteristic anti-PLA2R antibodies of primary MGN may become established, but the diagnosis currently rests on renal biopsy showing characteristic subepithelial granular immune deposits. These usually contain immunoglobulin G4 and complement. Other patterns may suggest secondary causes of MGN. Secondary membranous nephropathy occurs in lupus and some other immune or autoimmune disorders, in hepatitis B infection, after exposure to some drugs or toxins, and in some cancers. Secondary causes are more common at extremes of age, and are often made obvious by the history or clinical picture. How hard to look for malignancy is controversial, but malignancy is much more likely in patients over 60 years, and may be apparent at presentation.

scholarly journals Membranous Glomerulonephritis as an Uncommon Presentation of Secondary Syphilis: A Reminder on Therapeutic Decision-Making in Clinical Practice

2020 ◽  
Vol 8 ◽  
pp. 232470962096721
Author(s):  
Faisal Inayat ◽  
Talal Almas ◽  
Syed Rizwan A. Bokhari ◽  
Aun Muhammad ◽  
Moh’d A. Sharshir
Keyword(s):  
Nephrotic Syndrome ◽  
Clinical Practice ◽  
Membranous Nephropathy ◽  
Adult Population ◽  
Relevant Literature ◽  
Immunosuppressive Treatment ◽  
Membranous Glomerulonephritis ◽  
Interesting Case ◽  
Secondary Syphilis ◽  
Uncommon Presentation

Membranous glomerulonephritis is one of the common causes of nephrotic syndrome in the adult population. It is idiopathic in the majority of patients, but the secondary forms can be seen in the setting of autoimmune disease, cancer, infection, and following exposure to certain medications. However, subclinical syphilis-related membranous nephropathy remains a particularly rare clinicopathologic entity in modern times. In this article, we chronicle an interesting case of latent syphilis masquerading as membranous glomerulonephritis, which resolved with benzathine penicillin without requiring immunosuppressive treatment. We further supplement this paper with a concise review of the relevant literature that delineates the utility of appropriate antibiotic therapy in the management of luetic membranous nephropathy. Clinicians should remain cognizant of secondary syphilis while evaluating patients for possible glomerulonephritis or those presenting with proteinuria. Additionally, patients with hepatitis B, hepatitis C, and human immunodeficiency virus infections are not infrequently coinfected with Treponema pallidum. Therefore, a high index of suspicion for systemic manifestations of syphilis such as nephrotic syndrome is warranted in the setting of a coinfection. Prompt diagnosis and treatment of syphilis may result in resolution of proteinuria, without the need for standard immunosuppressive therapy commonly used in clinical practice.

scholarly journals Successful foetal outcome in a patient with primary membranous nephropathy and circulating anti-phospholipid antibodies: A case report

2018 ◽  
Keyword(s):  
Nephrotic Syndrome ◽  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Membranous Glomerulonephritis ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Phospholipase A2 Receptor ◽  
Foetal Outcome ◽  
Circulating Autoantibodies ◽  
Patient’S History

There is little information about pregnancy outcomes in patients with active membranous nephropathy (MN), especially those with circulating autoantibodies to M-type phospholipase A2 receptor (PLA2R), the major autoantigen in primary MN. Membranous glomerulonephritis (MGN) represents an immunologically mediated disease characterized by deposition of immune complexes in the glomerular subepithelial space, frequently associated with circulating M-type phospholipase A2 receptor. Nephrotic syndrome (massive proteinuria and hypoalbuminemia) at diagnosis predicts poor prognosis. Pregnancy with active MGN is high risk for foetal loss, intrauterine growth restriction, and pre-eclampsia, and may worsen maternal renal function, especially with the presence of antiphospholipid antibody syndrome (APLA). We report a 23-year-old gravida in her first pregnancy, suffering from MGN and severe nephrotic syndrome, complicated by APLA syndrome. The patient was treated with enoxaparin, aspirin azathioprine, and Prednisone for a short time, in addition to furosemide and albumin intravenously. She was delivered at 30 weeks due to deteriorating maternal and foetal conditions. A successful neonatal and maternal outcome was achieved in this case. The patient's history revealed thrombocytopenia and APLA syndrome and continues to be treated chronically with enoxaparin. Kidney biopsy performed after delivery showed membranous MGN stage II-III. Herein, we present a case of successful pregnancy and foetal outcome in a young woman with APLA syndrome and MN. Keywords: Membranous GN, Nephrotic Syndrome, Anti-Phospholipid Antibodies.

Sign in / Sign up

Export Citation Format

Share Document