scholarly journals Ethnic Variation in the Annual Rates of Adult Inflammatory Bowel Disease in Hospitalized Patients in Vancouver, British Columbia

2011 ◽  
Vol 25 (2) ◽  
pp. 73-77 ◽  
Author(s):  
Birinder K Mangat ◽  
Chad Evaschesen ◽  
Tim Lee ◽  
Eric M Yoshida ◽  
Baljinder Salh
Keyword(s):  
Inflammatory Bowel Disease ◽  
British Columbia ◽  
South Asian ◽  
Bowel Disease ◽  
South Asians ◽  
Adult Population ◽  
Asian Population ◽  
Annual Rate ◽  
Inflammatory Bowel ◽  
Extent Of Disease

BACKGROUND: There is currently little available information regarding the impact of ethnicity on the clinical features of inflammatory bowel disease (IBD). Migrating populations and changing demographics in Vancouver, British Columbia (BC) provide a unique opportunity to examine the role of ethnicity in the prevalence, expression and complications of IBD.OBJECTIVES: To determine the demographics of IBD and its subtypes leading to hospitalization in the adult population of BC.METHODS: A one-year retrospective study was performed for all patients who presented acutely with IBD to Vancouver General Hospital from January 1, 2006 to December 31, 2006. Data regarding sex, age, ethnicity, IBD type and extent of disease, complications and management strategies were collected. Clinical data were confirmed by pathology and radiology reports.RESULTS: There were 186 cases of IBD comprising Crohn’s disease (CD) 56%, ulcerative colitis (UC) 43% and indeterminate colitis (1%) 1%. The annual rate of IBD cases warranting hospitalization in Caucasians was 12.9 per 100,000 persons (7.9 per 100,000 persons for CD and 5.0 per 100,000 persons for UC). This was in contrast to the annual rate of IBD in South Asians at 7.7 per 100,000 persons (1.0 per 100,000 persons for CD and 6.8 per 100,000 persons for UC) and in Pacific Asians at 2.1 per 100,000 persons (1.3 per 100,000 persons for CD, 0.8 per 100,000 persons for UC). The male to female ratio was higher in South Asians and Pacific Asians than in Caucasians. The extent of disease was significantly different across racial groups, as was the rate of complications.CONCLUSIONS: These early results suggest that there are ethnic disparities in the annual rates of IBD warranting hospitalization in the adult population of BC. There was a significantly higher rate of CD in the Caucasian population than in South Asian and Pacific Asian populations. The South Asian population had a higher rate of UC, with an increased rate of complications and male predominance. Interestingly, the rate of CD and UC was lowest in the Pacific Asian population. These racial differences – which were statistically significant – suggest a role for ethnodiversity and environmental changes in the prevalence of IBD in Vancouver.

Mo1356 Inflammatory Bowel Disease in the Pediatric South Asian Population of British Columbia, Canada: A Distinct and Severe Phenotype

2013 ◽  
Vol 144 (5) ◽  
pp. S-645-S-646
Author(s):  
Matthew W. Carroll ◽  
Hira S. Gill ◽  
Jonathan Simkin ◽  
Lee-Ann M. Carroll ◽  
Vered Pinsk ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
British Columbia ◽  
South Asian ◽  
Bowel Disease ◽  
Asian Population ◽  
Severe Phenotype ◽  
South Asian Population ◽  
Inflammatory Bowel

scholarly journals Genetic associations of inflammatory bowel disease in a South Asian population

2018 ◽  
Vol 6 (15) ◽  
pp. 908-915 ◽  
Author(s):  
Madunil Anuk Niriella ◽  
Isurujith Kongala Liyanage ◽  
Senerath Kuleesha Kodisinghe ◽  
Arjuna Priyadarsin De Silva ◽  
Nimna Rajapakshe ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
South Asian ◽  
Bowel Disease ◽  
Asian Population ◽  
Genetic Associations ◽  
South Asian Population ◽  
Inflammatory Bowel

Inflammatory Bowel Disease in the South Asian Pediatric Population of British Columbia

2007 ◽  
Vol 102 (5) ◽  
pp. 1077-1083 ◽  
Author(s):  
Vared Pinsk ◽  
Daniel A. Lemberg ◽  
Karan Grewal ◽  
Collin C. Barker ◽  
Richard A. Schreiber ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
British Columbia ◽  
South Asian ◽  
Bowel Disease ◽  
Pediatric Population ◽  
The South ◽  
Inflammatory Bowel

scholarly journals The Need for Culturally Competent Care Within Gastroenterology Services: Evidence from Research with Adults of South Asian Origin Living with Inflammatory Bowel Disease

2020 ◽  
Author(s):  
Suzanne Mukherjee ◽  
Bryony Beresford ◽  
Karl Atkin ◽  
Shaji Sebastian
Keyword(s):  
Inflammatory Bowel Disease ◽  
South Asian ◽  
Bowel Disease ◽  
Extended Family ◽  
Religious Faith ◽  
Asian Population ◽  
Structured Interviews ◽  
South Asian Population ◽  
Asian Populations ◽  
Inflammatory Bowel

Abstract Background and Aims It is widely acknowledged that the incidence of inflammatory bowel disease [IBD] is rising within South Asian populations, yet research into the experiences of this group of patients is rare. In this study the lived experiences of UK South Asian adults with IBD, including support from gastroenterology services, was investigated. Methods A sample of 33 patients representing the diversity of the UK South Asian population were recruited through five gastroenterology clinics in England. In-depth semi-structured interviews were conducted, audio-recorded, transcribed and analysed using the Framework approach. Results Although many experiences align with those of the general IBD population, participants believed that South Asian cultures and/or religions can lead to additional challenges. These are linked to: family and friends’ understanding of IBD; self and family attributions regarding IBD; stigma surrounding ill health; the taboo of bowel symptoms; managing ‘spicy food’; beliefs about food and ill health; roles within the family; living with extended family; the use of complementary and alternative therapies; and visits to family overseas. Religious faith helped many to cope with having IBD, but symptoms could hamper their ability to practise faith. Gastroenterology services were viewed positively, but unmet needs were identified, some of which were culturally specific. Conclusion Gastroenterology services have an important role to play in helping patients to overcome the challenges they encounter in their everyday life, both by providing individual patients with culturally appropriate care and advice, and via interventions to increase awareness and understanding of IBD within wider South Asian communities.

South Asian Patients With Inflammatory Bowel Disease in the United States Demonstrate More Fistulizing and Perianal Crohn Phenotype

2020 ◽  
Vol 26 (12) ◽  
pp. 1933-1942 ◽  
Author(s):  
Sushrut Jangi ◽  
Alex Ruan ◽  
Joshua Korzenik ◽  
Punyanganie de Silva
Keyword(s):  
United States ◽  
Inflammatory Bowel Disease ◽  
South Asian ◽  
Bowel Disease ◽  
South Asians ◽  
The United States ◽  
Phenotypic Characteristics ◽  
Asian Patients ◽  
Inflammatory Bowel ◽  
White Patients

Abstract Background South Asians have recently been identified as having a rapidly rising incidence and prevalence of inflammatory bowel disease (IBD) throughout the world. However, longitudinal phenotypic studies of South Asians living in the United States remain scarce. Methods We retrospectively studied 171 South Asian patients with IBD treated at 2 US tertiary centers who presented between 2000 and 2016. South Asian IBD patients were randomly matched in a 1:2 ratio with sex and IBD subtype–matched (ulcerative colitis [UC] vs Crohn disease [CD]) white control patients (n = 342). Demographic and phenotypic characteristics were evaluated and compared between the 2 groups. Odds ratios (OR), logistic regression, and survival analysis were performed using R studio and STATA. Results 81 South Asian patients and 162 white patients had CD, and 90 South Asians and 180 white patients had UC. Among the CD group, South Asian patients were diagnosed at a median older age (age 28) than white patients (21 years; P < 0.003). Fistulizing disease (24.1% vs 8.6%; P < 0.002), perianal disease (20.3% vs 2.5%; P < 0.005), and presentation of rectal pain (16.2% vs 2.9%; P < 0.001) were more common among South Asian patients with CD than among white patients. After adjusting for covariates, South Asian patients with CD were less likely to be placed on thiopurines (OR = 0.36; P < 0.007) or to receive more than 1 biologic (OR = 0.42; P < 0.040). South Asian patients with UC were less likely to have proctitis (10% vs 22.2%; P < 0.022) and more likely to have primary sclerosing cholangitis (n = 7 vs n = 2; P < 0.007). South Asian patients born in the United States or those who had migrated before age 5 were younger at the age of IBD diagnosis (age 18.9 vs 32.4; P < 0.0005). Conclusion We found unique demographic and phenotypic characteristics among South Asian patients, including more penetrating disease in those with CD and less proctitis among those with UC, along with altered medication use patterns. Distinct environmental exposures and a potentially unique genetic profile of South Asian patients may confer this variable phenotypic expression, influencing management of this increasingly at-risk population.

Pediatric Inflammatory Bowel Disease Among South Asians Living in British Columbia, Canada

2016 ◽  
Vol 22 (2) ◽  
pp. 387-396 ◽  
Author(s):  
Matthew W. Carroll ◽  
Zachary Hamilton ◽  
Hira Gill ◽  
Jonathan Simkin ◽  
Matthew Smyth ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
British Columbia ◽  
Bowel Disease ◽  
South Asians ◽  
Pediatric Inflammatory Bowel Disease ◽  
Inflammatory Bowel

Comparison of Disease Phenotypes and Clinical Characteristics Among South Asian and White Patients with Inflammatory Bowel Disease at a Tertiary Referral Center

2020 ◽  
Vol 26 (12) ◽  
pp. 1869-1877
Author(s):  
Vimal Bodiwala ◽  
Timothy Marshall ◽  
Kiron M Das ◽  
Steven R Brant ◽  
Darren N Seril
Keyword(s):  
Inflammatory Bowel Disease ◽  
Clostridium Difficile ◽  
South Asian ◽  
Bowel Disease ◽  
South Asians ◽  
Tertiary Referral ◽  
Tertiary Referral Center ◽  
Asian Patients ◽  
Inflammatory Bowel ◽  
White Patients

Abstract Background The prevalence and clinical features of inflammatory bowel disease (IBD) vary among different racial and ethnic groups. The aim of this study was to compare the clinical and phenotypic features of Crohn’s disease (CD) and ulcerative colitis (UC) in South Asian patients living in the United States with those of a white cohort. Methods The demographic, clinical, and phenotypic characteristics of 73 South Asian patients (31 CD and 42 UC) who presented initially to our tertiary referral center from 2012 to 2016 and had subsequent follow-up were retrospectively compared with those of 408 consecutive white patients (245 CD and 163 UC). Results South Asian IBD patients were significantly more likely to have UC (58.0% vs 40.0%; P = 0.005) than white patients. South Asians with CD were less likely to have a family history of IBD (9.7% vs 26.9%; P = 0.037) and required fewer CD-related surgeries (22.5% vs 46.1; P = 0.012). South Asians were also less likely to be active or former smokers in both the CD (P = 0.004) and UC (P = 0.020) groups. South Asians with UC had a higher incidence of Clostridium difficile infection compared with white patients (19.0% vs 8.6%; P = 0.050). Conclusions A cohort of South Asian patients with IBD were more likely to have UC and had differing family and tobacco risk factors, requirements for surgery, and Clostridium difficile infection rates as compared with white patients.

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