A Case Report of a Metastatic Gastrointestinal Stromal Tumor Occurring in Femur

Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms that most commonly affect the stomach or small intestine, but can occur anywhere throughout the gastrointestinal tract. To the best of our knowledge, few cases have been reported in the literature about the femur metastasis of GIST. This paper describes a metastasis of a gastrointestinal stromal tumour (GIST) to the femur in a 62-year-old male, 2 years after treatment for a gastric primary. There were no signs of tumor recurrence at followup after 12 mo. This case suggests that the femur can be a potential metastatic site of GIST.

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Giant gastrointestinal stromal tumor of ileum: the gist of GIST: a case report

International Surgery Journal ◽

10.18203/2349-2902.isj20170868 ◽

2017 ◽

Vol 4 (3) ◽

pp. 1096

Author(s):

M. S. Ray ◽

B. S. Deepak

Keyword(s):

Case Report ◽

Gastrointestinal Tract ◽

Gastrointestinal Stromal Tumor ◽

Gastrointestinal Stromal Tumors ◽

Standard Of Care ◽

Clinical Situation ◽

Stromal Tumor ◽

Curative Therapy ◽

Stromal Tumors ◽

Mesenchymal Neoplasms

Gastrointestinal stromal tumors (GIST) are relatively rare pathology as compared with other mitotic lesions of GIT. However, GIST is the most common mesenchymal neoplasms of the gastrointestinal tract. Biopsy of the lesion and Immuno-Histo-Chemistry (IHC) for CD117 confirms the diagnosis. Surgery remains the standard of care and only potentially curative therapy for patients with primary, resectable, localized gastrointestinal stromal tumor. However, chemotherapy with Imatinib is added in neoadjuvant or adjuvant form according to clinical situation, and histopathological status of the lesion.

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Primary Extra-gastrointestinal Stromal Tumor of Retroperitoneum

Clinical Medicine Insights Oncology ◽

10.4137/cmo.s9180 ◽

2012 ◽

Vol 6 ◽

pp. CMO.S9180 ◽

Cited By ~ 10

Author(s):

Claudio Casella ◽

Vincenzo Villanacci ◽

Filippo D'adda ◽

Manuela Codazzi ◽

Bruno Salerni

Keyword(s):

Gastrointestinal Tract ◽

Gastrointestinal Stromal Tumor ◽

Gastrointestinal Stromal Tumors ◽

Stromal Tumor ◽

Radiological Evaluation ◽

Retroperitoneal Mass ◽

Stromal Tumors ◽

Mesenchymal Neoplasms ◽

Paravertebral Region ◽

Histology And Immunohistochemistry

Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. More rarely neoplasms with histology and immunohistochemistry similar to GISTs may occur outside the gastrointestinal tract (omentum, mesentery and retroperitoneum) and are so-called Extra-gastrointestinal Stromal Tumors (EGISTs). EGISTs arising in the retroperitoneum are extremely rare: to date, only 58 cases have been reported in the literature. Case Report We herein report a case of a primary EGIST of the retroperitoneum surgically treated. The pre-operative radiological evaluation showed a retroperitoneal mass, placed in left paravertebral region. Results Morphological and immunohistochemical features led to a diagnosis of extra-gastrointestinal stromal tumor (intermediate-low risk form). Conclusions As a result of the rarity of reports of primary EGISTs of retroperitoneum we need to analyze the data of reported cases in order to gain a better understanding about the pathogenesis, prognosis and optimal treatment of this disease.

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Large Omental Metastases of a Gastrointestinal Stromal Tumor

Medicina ◽

10.3390/medicina47110086 ◽

2011 ◽

Vol 47 (11) ◽

pp. 86

Author(s):

Povilas Ignatavičius ◽

Tomas Petraitis ◽

Žilvinas Saladžinskas ◽

Lilija Butkevičienė ◽

Kristina Žvinienė

Keyword(s):

Case Report ◽

Gastrointestinal Tract ◽

Gastrointestinal Stromal Tumor ◽

Gastrointestinal Stromal Tumors ◽

Interstitial Cells Of Cajal ◽

Metastatic Tumor ◽

Stromal Tumor ◽

Mesenchymal Tumors ◽

Stromal Tumors ◽

Cells Of Cajal

Gastrointestinal stromal tumors are rare tumors, originating from the interstitial cells of Cajal. They are the most common mesenchymal tumors of the gastrointestinal tract. Metastatic tumor is treated with imatinib mesylate. A case of large metastases of a gastrointestinal stromal tumor to the omentum, diagnosis and treatment principles are presented in this case report.

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Bone Metastases from Gastrointestinal Stromal Tumor: A Case Report

Case Reports in Oncological Medicine ◽

10.1155/2012/509845 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 4

Author(s):

Jihen Feki ◽

Racem Bouzguenda ◽

Lobna Ayedi ◽

Moez Bradi ◽

Tahia Boudawara ◽

...

Keyword(s):

Small Intestine ◽

Case Report ◽

Gastrointestinal Stromal Tumors ◽

Clinical Characteristics ◽

Sternoclavicular Joint ◽

Imaging Features ◽

Stromal Tumors ◽

Mesenchymal Neoplasms ◽

Metastatic Sites ◽

Metastatic Location

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Their most common metastatic sites are the liver and the peritoneum, but GISTs rarely metastasize to the bones. We report a case of a 58-year-old man with sternoclavicular joint metastasis from a GIST manifesting 28 months after surgical resection of the small intestine tumor. We will discuss through this paper and a literature review the clinical characteristics, imaging features, and management of this unusual metastatic location of GIST.

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Extra-Gastrointestinal retroperitoneal giant stromal tumor complicated with intra-tumoral hemorrhage: case report and literature review

ARS Medica Tomitana ◽

10.1515/arsm-2015-0011 ◽

2015 ◽

Vol 21 (1) ◽

pp. 1-6

Author(s):

B.A. Suciu ◽

V. Bud ◽

Doina Milutin ◽

Ioana Halmaciu ◽

C. Constantin ◽

...

Keyword(s):

Case Report ◽

Gastrointestinal Tract ◽

Literature Review ◽

Gastrointestinal Stromal Tumor ◽

Gastrointestinal Stromal Tumors ◽

Stromal Tumor ◽

Stromal Tumors ◽

Pathological Characteristics ◽

Mesenchymal Origin ◽

Extragastrointestinal Stromal Tumor

Abstract Gastrointestinal stromal tumors are an uncommon sarcomas with mesenchymal origin that arises in the gastrointestinal tract. Recently, most of the published reports describe such tumors located outside of the gastrointestinal tract, with similar pathological characteristics and are named extra-gastrointestinal stromal tumors. We report the case of a patient suffering for a giant retroperitoneal extra-gastrointestinal stromal tumor, complicated with intra-tumoral hemorrhage. The particularity of this case is the presence of the intra-tumoral hemorrhage in a retroperitoneal extragastrointestinal stromal tumor that grew rapidly in volume (in 1 week).

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A gastrointestinal stromal tumor: Case report

Medicinski pregled ◽

10.2298/mpns0210423t ◽

2002 ◽

Vol 55 (9-10) ◽

pp. 423-426

Author(s):

Viktor Till ◽

Matilda Djolai ◽

Borut Pilipovic ◽

Slavica Senicar ◽

Ljiljana Hadnadjev ◽

...

Keyword(s):

Computed Tomography ◽

Small Intestine ◽

Case Report ◽

Gastrointestinal Stromal Tumor ◽

Superior Mesenteric Artery ◽

Mesenteric Artery ◽

Gastrointestinal Stromal Tumors ◽

Abdominal Cavity ◽

Stromal Tumor ◽

Stromal Tumors

Introduction Gastrointestinal stromal tumors represent extremely rare tumors of the gastrointestinal system, especially when localized on the small intestine. Case report We report a case of a female patient, with recurrent gastrointestinal bleeding and severe anemia, caused by gastrointestinal stromal tumor of the small intestine. After negative endoscopic findings, she underwent radiological examination of the small intestine. Primary diagnostic radiological evaluation included: small intestine passage enteroclysis, computed tomography of the abdominal cavity and selective angiographic study of the three major aortic branches that supply the gastrointestinal tract in the abdomen (celiac axis, superior mesenteric artery and inferior mesenteric artery). Secondly, ultrasound of abdominal cavity was performed. Findings of small intestine passage and enteroclysis were negative. The tumor was visualized by computed tomography and ultrasound, but without distinctive anatomical localization in the abdominal cavity. Discussion The diagnostic dilemma has been resolved by using selective angiographic examination of celiac axis and superior mesenteric artery and thus a tumor formation was visualized in the mesenterium of the small intestine. Radiological findings were confirmed by surgery. Histopathological findings were positive for gastrointestinal stromal tumor. Conclusion Gastrointestinal stromal tumors of the small intestine rarely cause recurrent bleeding, but they should be included in differential diagnosis.

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Massive hemorrhage of upper gastrointestinal tract caused by gastrointestinal stromal tumor of the stomach: Case report

Medicinski pregled ◽

10.2298/mpns1208341l ◽

2012 ◽

Vol 65 (7-8) ◽

pp. 341-345

Author(s):

Nenad Lalovic ◽

Nikolina Dukic-Vladicic ◽

Radmil Maric ◽

Mirjana Cuk ◽

Milan Simatovic ◽

...

Keyword(s):

Case Report ◽

Gastrointestinal Tract ◽

Gastrointestinal Stromal Tumor ◽

Gastrointestinal Stromal Tumors ◽

Digestive System ◽

Massive Hemorrhage ◽

Stromal Tumor ◽

Acute Bleeding ◽

Stromal Tumors ◽

Upper Gastrointestinal

Introduction. Acute bleeding from the upper gastrointestinal system is a medical emergency which is followed by high mortality rate, ranging from 6 to 15% in spite of modern diagnostic methods and treatment. Bleeding from the upper gastrointestinal system may be caused by gastrointestinal stromal tumors of the stomach, which are mainly characterized by occult bleeding, while profuse bleeding rarely occurs accompanied by hemorrhagic shock. Gastrointestinal stromal tumors of stomach are the most common mesenchimal tumors of the gastrointestinal tract. Case Report. In our study we showed a 60-year-old female patient with profuse bleeding from the stomach and the clinical picture of severe hemorrhagic shock, caused by gastrointestinal stromal tumor. An ovoid junction, raised towards the lumen, covered with ulcerated mucosa in several places and followed by massive arterial bleeding was found intraoperatively, after the performed gastrotomy. Histopathological examination with immunohistochemical analysis confirmed that this was a gastrointestinal stromal tumor of the stomach. Discussion. Acute bleeding from the digestive system is a sudden and serious condition of the body. Urgent esophagogastroduodenoscopy is a sensitive and specific diagnostic and therapeutic method of choice. Massive bleeding from the upper gastrointestinal tract is very rarely caused by gastrointestinal stromal tumors, whose clinical picture is very heterogeneous and depends on tumor size and location. Abundant bleeding from the tumor is an indication for urgent surgical intervention. Conclusion. According to the literature massive hemorrhage of the upper digestive system can rarely be caused by gastrointestinal stromal tumor of the stomach. It is shown that abundant hemorrhage of the upper digestive tract can be caused with gastric gastrointestinal stromal tumor. Surgical resection is the main form of treatment of gastrointestinal stromal tumors of the digestive system and bleeding from these tumors caused by failure of endoscopic hemostasis.

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Gastrointestinal Perforation Due to Gastrointestinal Stromal Tumour (GIST) In Small Intestine-A Case Report

Journal of Surgical Sciences ◽

10.3329/jss.v20i2.43819 ◽

2019 ◽

Vol 20 (2) ◽

pp. 65-67

Author(s):

SM lftekhar Uddeen Sagar ◽

AMSM Sharfuzzaman ◽

SM Nazrul Lslam ◽

Md Mahamudul Hasan

Keyword(s):

Small Intestine ◽

Case Report ◽

Gastrointestinal Stromal Tumors ◽

Abdominal Mass ◽

Gastrointestinal Stromal Tumour ◽

Early Recurrence ◽

Gi Bleeding ◽

Gi Tract ◽

Stromal Tumors ◽

Small Intestinal

Gastrointestinal stromal tumors (GISTs) is a mesenchymal tumor of GI tract. Now a daysdiagnosis of GISTs is more frequent then previous due to advance diagnostic tool. GISTsusually present with abdominal mass and GI bleeding but it may also present with manyunusual pattern like obstruction, perforation. Perforation of GISTs is extremely rare presentation.We report a case of pneumoperitoneum due to perforation of small intestinal GIST.Emergency laparotomy followed by resection and end to end anastomosis was done. Aftersurgical treatment lmatinibmesylate was given for prevention of early recurrence. Journal of Surgical Sciences (2016) Vol. 20 (2) :65-67

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Malignant Gastrointestinal Stromal Tumour with Metastasis

International Journal of Recent Surgical and Medical Sciences ◽

10.1055/s-0039-1678630 ◽

2015 ◽

Vol 01 (01) ◽

pp. 031-033

Author(s):

Bhushita Lakhar ◽

Nilesh Guru

Keyword(s):

Gastrointestinal Stromal Tumors ◽

Gastrointestinal Stromal Tumour ◽

Anatomic Site ◽

Stromal Tumors ◽

Mesenchymal Neoplasms ◽

Imaging Characteristics ◽

The World ◽

Mitotic Frequency ◽

Malignant Lesions

AbstractGastrointestinal stromal tumors (GISTs) are the most usual mesenchymal neoplasms of the gastrointestinal tract. Ever since the classification of GIST as an entity distinct from leiomyoma's, leiomyosarcomas, etc., there has been an increased concern in defining their imaging characteristics. It is estimated that approximately 5000-10,000 people are affected per year by this tumor all over the world. Most GISTs are benign (70-80%). However, these tumors have a spectrum ranging from benign to malignant lesions, depending on its anatomic site, tumor size, and mitotic frequency. We report a case of multiple malignant GIST with metastasis into Liver.

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