Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents

A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-free under microwave irradiation. The synthesized compounds showed a good anti-inflammatory, antibacterial, and antifungal activity.

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Synthesis and biological evaluation of novel d-glucose-derived 1,2,3-triazoles as potential antibacterial and antifungal agents

Medicinal Chemistry Research ◽

10.1007/s00044-014-1123-9 ◽

2014 ◽

Vol 24 (1) ◽

pp. 182-196 ◽

Cited By ~ 22

Author(s):

Hui-Zhen Zhang ◽

Jin-Jian Wei ◽

Kannekanti Vijaya Kumar ◽

Syed Rasheed ◽

Cheng-He Zhou

Keyword(s):

Antifungal Agents ◽

Biological Evaluation ◽

Antibacterial And Antifungal ◽

Synthesis And Biological Evaluation

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Synthesis and biological Evaluation of Some Abbreviated New Triazolopyrimidines

International Journal of Scientific Research in Science and Technology ◽

10.32628/ijsrst1207250 ◽

2019 ◽

pp. 354-361

Author(s):

Jatin Vora ◽

Kartik Vyas

Keyword(s):

Biginelli Reaction ◽

Biological Evaluation ◽

Spectroscopic Techniques ◽

The Novel ◽

Antibacterial And Antifungal Activity ◽

1H Nuclear Magnetic Resonance ◽

Elemental Analyses ◽

Antibacterial And Antifungal ◽

Synthesis And Biological Evaluation ◽

Compound Series

A cogent synthesis of completely new compound series of by 6-(3,5-bis(trifluoromethyl)phenyl)-4-(4-chlorophenyl)-3,4-dihydro pyrimidine-2(1H)-one (Biginelli reaction) was achieved by continue heating of (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one and urea for 5 hours with 40% KOH and ethyl alcohol. (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one is produced by Claisen-Schmidt Condensation. In this condensation 1-(3,5-bis(trifluoromethyl)phenyl)ethanone and different aldehyde are mixed. All the novel compound series were characterized by infrared and 1H nuclear magnetic resonance and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity

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Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff’s Bases of Sulphonamides

International Journal of Current Pharmaceutical Review and Research ◽

10.25258/ijcprr.v8i03.9213 ◽

2017 ◽

Vol 8 (03) ◽

Author(s):

Neeraj Kumar ◽

Dhruti Bhatt ◽

Chandra Shekhar Sharma ◽

Hamendra Pratap Singh ◽

Harshda Pandiya ◽

...

Keyword(s):

Antibacterial Activity ◽

Antifungal Activity ◽

Biological Evaluation ◽

Antibacterial And Antifungal Activity ◽

Schiff’S Bases ◽

E Coli ◽

Schiff's Bases ◽

Microbial Strains ◽

Antibacterial And Antifungal ◽

Synthesis And Biological Evaluation

A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalcone derivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested for antibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A. clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significant antibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.

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