scholarly journals Impact of Sleep Respiratory Disorders on Endothelial Function in Children

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Luigia Brunetti ◽  
Ruggiero Francavilla ◽  
Pietro Scicchitano ◽  
Valentina Tranchino ◽  
Maria Loscialpo ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Sleep Disordered Breathing ◽  
Sleep Apnea Syndrome ◽  
Population Sample ◽  
Paediatric Population ◽  
Risk Profile ◽  
Cardiovascular Risk Profile ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Flow Mediated Vasodilation

Obstructive sleep apnea syndrome (OSAS) in children can induce endothelial dysfunction, a well-known early marker of atherosclerosis. The study aimed to evaluate a link among endothelial function (measured by flow-mediated vasodilation (FMD)), obesity (evaluated by body mass index (BMI)), and sleep disordered breathing (SDB), assessed with apnoea/hypopnoea index (AHI), in a paediatric population. We demonstrated that our little OSAS patients showed an impaired endothelial function as compared to controls. In particular, the higher the AHI, the worst the FMD values and thus the endothelial function. Although the population sample is small, this study demonstrated that OSAS could impair endothelial function and worsen cardiovascular risk profile since childhood.

scholarly journals Evaluation of endothelial function and cardiovascular risk in non-obese patients with slight degree of obstructive sleep apnea syndrome

2017 ◽  
Vol 87 (3) ◽  
Author(s):  
Fiorella Devito ◽  
Annapaola Zito ◽  
Silvano Dragonieri ◽  
Pierluigi Carratù ◽  
Vitaliano N. Quaranta ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Endothelial Function ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Intima Media Thickness ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Recently, it has been clearly described an independent relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular risk, with underlying mechanisms also including endothelial dysfunction. We enrolled 32 consecutive non-obese patients (mean age of 39.5±11.5 years), of which 16 with mild OSAS and 16 snoring without OSAS. Mild OSAS is defined by an AHI index between 5 and 15. We have investigated if whether there was a relationship between mild OSAS, endothelial function and carotid intima-media thickness (C-IMT). The population was divided into two groups: Group 1 (16 simple snorer patients with an average age of 39.4±12.1 years) and Group 2 (16 subjects with mild OSAS with an average age of 39.6±11.2 years). Each group underwent cardiovascular investigation including measurement of flow-mediated dilation (FMD) of the brachial artery and C-IMT. Both groups comprised non-obese subjects. Patients with mild OSAS had serum total cholesterol values statistically significantly higher than simple snores patients (178.6±24.9 vs 159.2±25.3; p=0.038). OSAS patients had also a trend towards higher values of maximum C-IMT compared to simple snorer patients (0.70±0.15 vs 0.65±0.16), although below the level of significance. Between the two groups, no difference was found for FMD values. The present results on mild OSAS strengthen the importance of a diagnosis of OSAS as soon as possible, in order to encourage all primary prevention interventions to correct risk factors responsible for disease progression and the occurrence of cardiovascular diseases, not excluding the use of therapies of non-invasive ventilation even in the early stages of the disease.

Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome

Lung ◽  
2015 ◽  
Vol 193 (6) ◽  
pp. 1037-1045 ◽  
Author(s):  
Wei-Ji Chen ◽  
Shwu-Fang Liaw ◽  
Ching-Chi Lin ◽  
Chung-Hsin Chiu ◽  
Mei-Wei Lin ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Endothelial Function ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Nasal Cpap ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Treatment of Snoring and Obstructive Sleep Apnea Syndrome

1995 ◽  
Vol 112 (5) ◽  
pp. P143-P143
Author(s):  
Samuel A. Mickelson ◽  
B. Tucker Woodson
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Diagnostic Tests ◽  
Sleep Disordered Breathing ◽  
Sleep Apnea Syndrome ◽  
Treatment Modalities ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Abnormal Sleep

Educational objectives: To discuss normal and abnormal sleep patterns, to understand the polysomnogram and the pathophysiology of snoring and obstructive sleep apnea syndrome, and to become familiar with advances in the management of sleep disordered breathing and to understand the various diagnostic tests and surgical and nonsurgical treatment modalities now available and to individualize the approach in surgical treatment.

scholarly journals Microvascular endothelial function in patients with obstructive sleep apnea syndrome

2018 ◽  
Vol 2 (1) ◽  
pp. 53-58
Author(s):  
Takuo Arikawa ◽  
Shigeru Toyoda ◽  
Masayuki Miyamoto ◽  
Keisuke Suzuki ◽  
Itsuo Nakajima ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Endothelial Function ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Microvascular Endothelial ◽  
Microvascular Endothelial Function
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