Restoration of Critical-Sized Defects in the Rabbit Mandible Using Autologous Bone Marrow Stromal Cells Hybridized with Nano-β-tricalcium Phosphate/Collagen Scaffolds
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Nano-β-tricalcium phosphate/collagen (n-β-TCP/Col) is considered with good osteoconductivity. However, the therapeutic effectiveness of n-β-TCP/Col scaffolds in combination with autologous bone marrow stromal cells (BMSCs) remains to be elucidated for the repair of critical-sized bone defects. In this study, we found that n-β-TCP/Col scaffolds exhibited high biocompatibilityin vitro. The introduction of BMSCs expandedin vitroto the scaffolds dramatically enhanced their efficiency to restore critical-sized bone defects, especially during the initial stage after implantation. Collectively, these results suggest that autologous BMSCs in n-β-TCP/Col scaffolds have the potential to be applied in bone tissue engineering.
2014 ◽
Vol 12
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pp. 123
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2008 ◽
Vol 29
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pp. 4211-4216
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2001 ◽
Vol 344
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pp. 385-386
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2006 ◽
Vol 7
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pp. 83
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2007 ◽
Vol 28
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pp. 1005-1013
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2006 ◽
Vol 168
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pp. 542-550
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2001 ◽
Vol 12
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pp. 594-595
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