scholarly journals Anti-Inflammatory and Antiarthritic Activity of Anthraquinone Derivatives in Rodents

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Ajay D. Kshirsagar ◽  
Prashant V. Panchal ◽  
Uday N. Harle ◽  
Rabindra K. Nanda ◽  
Haidarali M. Shaikh
Keyword(s):  
Complete Freund’S Adjuvant ◽  
Inflammatory Activity ◽  
Pharmacokinetic Data ◽  
Adjuvant Induced Arthritis ◽  
Aloe Emodin ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant ◽  
Anti Inflammatory

Aloe emodin is isolated compound of aloe vera which is used traditionally as an anti-inflammatory agent. In vitro pharmacokinetic data suggest that glucuronosyl or sulfated forms of aloe emodin may provide some limitations in its absorption capacity. Aloe emodin was reported to have in vitro anti-inflammatory activity due to inhibition of inducible nitric oxide (iNO) and prostaglandin E2, via its action on murine macrophages. However, present work evidenced that molecular docking of aloe emodin modulates the anti-inflammatory activity, as well as expression of COX-2 (cyclooxygenase-2) in rodent. The AEC (4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2 carboxylic acid) was synthesized using aloe emodin as starting material. The study was planned for evaluation of possible anti-inflammatory and antiarthritic activity in carrageenan rat induced paw oedema and complete Freund’s adjuvant induced arthritis in rats. The AE (aloe emodin) and AEC significantlyP<0.001reduced carrageenan induced paw edema at 50 and 75 mg/kg. Complete Freund’s adjuvant induced arthritis model showed significantP<0.001decrease in injected and noninjected paw volume, arthritic score. AE and AEC showed significant effect on various biochemical, antioxidant, and hematological parameters. Diclofenac sodium 10 mg/kg showed significantP<0.001inhibition in inflammation and arthritis.

scholarly journals Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Srinivasa Reddy Jitta ◽  
Prasanthi Daram ◽  
Karthik Gourishetti ◽  
C. S. Misra ◽  
Picheswara Rao Polu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Complete Freund’S Adjuvant ◽  
Inflammatory Activity ◽  
Aqueous Extracts ◽  
Adjuvant Induced Arthritis ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant ◽  
Anti Inflammatory

Terminalia tomentosa bark belongs to the family Combretaceae. The plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea. Phytochemical investigation of T. tomentosa bark confirms the presence of flavonoids, polyphenols, and tannins. The plant has not been investigated for its anti-inflammatory and antiarthritic activity. The present study was undertaken to explore its possible anti-inflammatory and antiarthritic activity. Anti-inflammatory activity of alcoholic and aqueous extracts of the bark was assessed by in vivo methods. In vivo antiarthritic potential of the extracts was evaluated by Complete Freund’s Adjuvant (CFA) induced arthritis in Wistar rats. Our findings showed that the alcoholic and aqueous extracts exhibited anti-inflammatory activity at 500 mg/kg oral dose in carrageenan-induced hind paw edema and carrageenan-induced air pouch inflammation models. We also found alcoholic as well as aqueous extracts of the bark restored the altered blood and serum parameters caused by the Complete Freund’s Adjuvant-induced arthritis in Wistar rats. This study shows that the T. tomentosa bark extracts possess anti-inflammatory activity and have pronounced effects on adjuvant arthritis also. Future studies are necessary to provide deeper insight into the exact mechanism of the action of anti-inflammatory and antiarthritic activity of T. tomentosa.

Ferulic acid ethyl ester diminished Complete Freund’s Adjuvant-induced incapacitation through antioxidant and anti-inflammatory activity

2015 ◽  
Vol 389 (1) ◽  
pp. 117-130 ◽  
Author(s):  
Francisco Valmor Macedo Cunha ◽  
Bruno de Sousa Gomes ◽  
Benedito de Sousa Neto ◽  
Alana Rodrigues Ferreira ◽  
Damião Pergentino de Sousa ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Ethyl Ester ◽  
Acid Ethyl Ester ◽  
Complete Freund’S Adjuvant ◽  
Inflammatory Activity ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant ◽  
Anti Inflammatory ◽  
Ferulic Acid Ethyl Ester

scholarly journals Evaluation of in vitro and in vivo anti-arthritic potential of Berberis calliobotrys

2015 ◽  
Vol 10 (4) ◽  
pp. 807 ◽  
Author(s):  
. Alamgeer ◽  
Umme Habiba Hasan ◽  
Ambreen Malik Uttra ◽  
Shahid Rasool
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Complete Freund’S Adjuvant ◽  
Membrane Stabilization ◽  
Adjuvant Induced Arthritis ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

<p class="Abstract">The present study was commenced to evaluate the anti-arthritic effect of 70% methanol extract and <em>n</em>-butanol and aqueous fractions of <em>Berberis calliobotrys</em> using both <em>in vitro</em> and <em>in vivo</em> arthritis models. Extract and fractions were investigated<em> in vitro</em> for inhibition of protein (bovine serum and egg albumin) denaturation and human red blood cell membrane stabilization. <em>In vivo</em> anti-arthritic activity of extract and fractions at 50, 100 and 200 mg/kg was assessed using turpentine oil and formaldehyde-induced arthritis, while, 200 mg/kg dose was evaluated against complete Freund’s adjuvant-induced arthritis. <em>B. calliobotrys</em> produced significant (p&lt;0.001) dose dependent inhibition of protein denaturation and human red blood cell membrane stabilization. In turpentine oil, formaldehyde and complete Freund’s adjuvant-induced arthritis models,<em> B. calliobotrys</em> significantly (p&lt;0.001) reduced joint and paw swelling. <em>B. calliobotrys</em> markedly improved body weight, hematology profile, radiological and histopathological parameters in complete Freund’s adjuvant model. It could be concluded that <em>B. calliobotrys</em> holds anti-arthritic potential, supporting its traditional use in treatment of rheumatoid arthritis.</p><br /><p> </p>

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