scholarly journals Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes againstMycobacterium tuberculosis

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Mustapha C. Mandewale ◽  
Bapu Thorat ◽  
Dnyaneshwar Shelke ◽  
Ramesh Yamgar
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Metal Complexes ◽  
Inhibitory Activity ◽  
Biological Properties ◽  
Biological Evaluation ◽  
Fluorescence Properties ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

A new series of quinoline hydrazone derivatives and their metal complexes have been synthesized and their biological properties have been evaluated againstMycobacterium tuberculosis(H37 RV strain). Most of the newly synthesized compounds displayed 100% inhibitory activity at a concentration of 6.25–25 μg/mL, againstMycobacterium tuberculosis. Fluorescence properties of all the synthesized compounds have been studied.

Synthesis and Biological Evaluation of Acetylcholinesterase Inhibitor Macakurzin C and Its Derivatives

Synlett ◽  
2015 ◽  
Vol 26 (08) ◽  
pp. 1131-1134 ◽  
Author(s):  
Hyoungsu Kim ◽  
Seung-Hoon Baek ◽  
Hongjun Jang
Keyword(s):  
Inhibitory Activity ◽  
Acetylcholinesterase Inhibitor ◽  
Biological Evaluation ◽  
Hydroxyl Groups ◽  
Structural Requirements ◽  
Ache Inhibitory Activity ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

The derivatives of macakurzin C containing a modified D ring and protected C(3)/C(5)-hydroxyl groups were synthesized and their in vitro AChE inhibitory activity and neurotoxicity were evaluated to identify the structural requirements for the activities. The results indicated that C(3)-benzyl-protected derivative has a more potent AChE inhibitory activity (IC50, 2.6 μM) and a less neurotoxicity (GI50, >100 μM) than synthetic macakurzin C (IC50, 9.1 μM; GI50, 16.6 μM).

Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis

2009 ◽  
Vol 17 (13) ◽  
pp. 4681-4692 ◽  
Author(s):  
Ram Shankar Upadhayaya ◽  
Girish M. Kulkarni ◽  
Nageswara Rao Vasireddy ◽  
Jaya Kishore Vandavasi ◽  
Shailesh S. Dixit ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Thiourea Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

2013 ◽  
Vol 10 (10) ◽  
pp. 935-941
Author(s):  
Yan Tang ◽  
Zhewei Tu ◽  
Jing Sun ◽  
Xiong Zhu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis

2006 ◽  
Vol 14 (13) ◽  
pp. 4610-4626 ◽  
Author(s):  
Ze-Qi Xu ◽  
Krzysztof Pupek ◽  
William J. Suling ◽  
Livia Enache ◽  
Michael T. Flavin
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation
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