scholarly journals Adipocyte-Like Differentiation in a Posttreatment Embryonal Rhabdomyosarcoma

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Dana Balitzer ◽  
Timothy H. McCalmont ◽  
Andrew E. Horvai
Keyword(s):  
Skeletal Muscle ◽  
Soft Tissue ◽  
Neoadjuvant Chemotherapy ◽  
Lower Extremity ◽  
Immunohistochemical Staining ◽  
Muscle Differentiation ◽  
Embryonal Rhabdomyosarcoma ◽  
Skeletal Muscle Differentiation ◽  
Unusual Phenomenon ◽  
Oil Red O

We describe a 16-year-old boy with rhabdomyosarcoma, consistent with embryonal subtype, of the lower extremity who received systemic neoadjuvant chemotherapy and subsequent excision. Microscopic sections of the postchemotherapy excision demonstrated diffuse, prominent, and immature adipocyte-like differentiation, in addition to skeletal muscle differentiation. Adipocyte-like differentiation was confirmed by a combination of positive Oil Red O and adipophilin immunohistochemical staining. To our knowledge, this represents the first report of an unusual phenomenon of differentiation of a soft tissue rhabdomyosarcoma into adipocyte-like cells after chemotherapy.

Pediatric Tumors: Rhabdomyosarcoma

2017 ◽  
Author(s):  
John Groundland ◽  
Sara Shaw ◽  
R L Randall
Keyword(s):  
Skeletal Muscle ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Cytotoxic Chemotherapy ◽  
Embryonal Rhabdomyosarcoma ◽  
Pediatric Tumors ◽  
Skeletal Muscle Differentiation ◽  
Systemic Control ◽  
Therapeutic Radiation ◽  
Pleomorphic Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a group of soft tissue sarcomas that share a common feature of primitive skeletal muscle differentiation. Three main subtypes have been characterized: embryonal, alveolar, and pleomorphic. Presentation and prognosis of RMS are highly variable, depending on anatomic location, subtype, and risk stratification. Currently, treatment centers on systemic control with cytotoxic chemotherapy and local control with surgery and/or therapeutic radiation. This review contains 3 figures, 10 tables and 50 references  Key words: alveolar rhabdomyosarcoma, embryonal rhabdomyosarcoma, pediatric soft tissue sarcoma, pleomorphic rhabdomyosarcoma, rhabdomyosarcona, t(2;13), t(1;13)

Pediatric Tumors: Rhabdomyosarcoma

2017 ◽  
Author(s):  
John Groundland ◽  
Sara Shaw ◽  
R L Randall
Keyword(s):  
Skeletal Muscle ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Cytotoxic Chemotherapy ◽  
Embryonal Rhabdomyosarcoma ◽  
Pediatric Tumors ◽  
Skeletal Muscle Differentiation ◽  
Systemic Control ◽  
Therapeutic Radiation ◽  
Pleomorphic Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a group of soft tissue sarcomas that share a common feature of primitive skeletal muscle differentiation. Three main subtypes have been characterized: embryonal, alveolar, and pleomorphic. Presentation and prognosis of RMS are highly variable, depending on anatomic location, subtype, and risk stratification. Currently, treatment centers on systemic control with cytotoxic chemotherapy and local control with surgery and/or therapeutic radiation. This review contains 3 figures, 10 tables and 50 references  Key words: alveolar rhabdomyosarcoma, embryonal rhabdomyosarcoma, pediatric soft tissue sarcoma, pleomorphic rhabdomyosarcoma, rhabdomyosarcona, t(2;13), t(1;13)

scholarly journals The expression of nestin delineates skeletal muscle differentiation in the developing rat esophagus

2011 ◽  
Vol 218 (3) ◽  
pp. 311-323 ◽  
Author(s):  
Peng-Han Su ◽  
Tung-Cheng Wang ◽  
Zong-Ruei Wong ◽  
Bu-Miin Huang ◽  
Hsi-Yuan Yang
Keyword(s):  
Skeletal Muscle ◽  
Muscle Differentiation ◽  
Skeletal Muscle Differentiation ◽  
Developing Rat

scholarly journals Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation

2016 ◽  
Vol 1863 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Anna Polesskaya ◽  
Guillaume Pinna ◽  
Yassine Sassi ◽  
Marie Vandamme ◽  
Anne Bigot ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Differentiation ◽  
Interleukin 8 ◽  
Skeletal Muscle Differentiation ◽  
Transcriptional Modulation
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