scholarly journals The Different Characteristics of Cirrus Optical Coherence Tomography between Superior Segmental Optic Hypoplasia and Normal Tension Glaucoma with Superior Retinal Nerve Fiber Defect

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Jong Chul Han ◽  
Da Ye Choi ◽  
Changwon Kee
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Normal Tension Glaucoma ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Superior Segmental Optic Hypoplasia ◽  
Different Characteristics ◽  
Normal Controls ◽  
Retinal Nerve Fiber

Purpose. To evaluate the different characteristics in superior segmental optic hypoplasia (SSOH) and normal tension glaucoma (NTG) with superior retinal nerve fiber layer (RNFL) defect (NTG-SRD) compared to normal control using cirrus optical coherence tomography (OCT).Methods. SSOH eyes and NTG-SRD eyes were reviewed. The peripapillary RNFL (pRNFL) and ganglion cell inner plexiform layer (GCIPL) of the two groups were compared to age-matched normal controls using cirrus OCT.Results. Included in this study were 31 SSOH eyes, 33 NTG patients, and 49 healthy normal controls. Compared to normal controls, pRNFL thickness in SSOH eyes was thinner except in the inferotemporal to the temporal segment. NTG-SRD eyes had thinner pRNFL except in the nasal to inferonasal segment. Meanwhile, GCIPL thickness in SSOH eyes was thinner in the global and sectoral segment, but not in the superonasal and inferonasal sectors compared to normal controls. NTG-SRD eyes showed thinner GCIPL in all sectors compared to normal controls. In case of comparison between SSOH and NTG-SRD, superonasal sector was thinner in NTG-SRD than in SSOH (P=0.03).Conclusions. The different distributions of nerve fiber layer were shown in pRNFL and GCIPL between SSOH eyes and NTG-SRD eyes.

scholarly journals Follow up Jangka Panjang Pada Glaukoma Tekanan Normal Bilateral

2020 ◽  
pp. 35-48
Author(s):  
Fauziyah Hayati
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Normal Tension Glaucoma ◽  
Optical Coherence ◽  
Prostaglandin Analog ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

Glaukoma adalah kelompok penyakit nervus optikus yang ditandai dengan adanya kehilangan sel ganglion retina secara progresif. Glaukoma merupakan penyebab kebutaan ireversibel di dunia. Glaukoma tekanan normal adalah salah satu jenis dari glaukoma primer sudut terbuka yang ditandai dengan adanya neuropati optik dan tekanan bola mata kurang dari 21 mmHg. Laporan kasus ini menceritakan seorang pasien wanita umur 55 tahun dengan keluhan utama mata tidak nyaman dan buram pada kedua mata. Akan tetapi dari pemeriksaan oftalmologi, tajam penglihatan terbaik menunjukkan nilai normal yaitu 6/6, segmen anterior bola mata normal, dan tekanan bola mata normal, lapang pandang normal, kelainan hanya didapatkan dari funduskopi menunjukkan adanya cupping pada kedua mata dan Optical Coherence Tomography (OCT) yang menggambarkan adanya penipisan Retinal Nerve Fiber Layer (RNFL). Pasien diberikan obat topikal golongan prostaglandin analog dan follow up selama 3 tahun. Dari hasil follow up yang panjang, tingkat kerusakan karena glaukoma tidak terlihat signifikan. Akan tetapi setelah dua tahun, terjadi defek lapang pandang meningkat secara signifikan, sehingga perlu penambahan obat untuk mencapai target tekanan bola mata. Kesimpulan dalam kasus ini. Sangat penting untuk mengetahui diagnosis Normal Tension Glaucoma (NTG) agar dapat membedakan dari jenis glaukoma lainnya. Diagnosis dan terapi pada NTG masih menjadi tantangan bagi dokter mata. Pemeriksaan oftalmologi secara serial perlu dilakukan untuk mencegah progresifitas kerusakan nervus optikus. Follow up jangka panjang diperlukan pada semua kasus glaukoma termasuk NTG. Pengobatan NTG harus disesuaikan sesuai dengan target tekanan bola mata yang diperlukan.

Retinal Nerve Fiber and Optic Disc Morphology Using Spectral-Domain Optical Coherence Tomography in Scleroderma Patients

2016 ◽  
Vol 27 (3) ◽  
pp. 281-284 ◽  
Author(s):  
Sevinc Sahin-Atik ◽  
Feray Koc ◽  
Sirin Akin-Sari ◽  
Mustafa Ozmen
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Optic Disc ◽  
Retinal Nerve Fiber Layer ◽  
Normal Tension Glaucoma ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Sd Oct ◽  
Retinal Nerve Fiber

Purpose To evaluate the optic nerve head parameters and peripapillary retinal nerve fiber layer using spectral-domain optical coherence tomography (SD-OCT) in a systemic sclerosis (SSc) cohort and age-matched controls to determine whether SSc patients have an increased risk of normal-tension glaucoma (NTG). Methods We examined 30 patients (3 male, 27 female) with SSc and 28 age- and sex-matched controls. Retinal nerve fiber and optic disc morphology were evaluated using Cirrus SD-OCT. Results Optic disc morphology measurements including disc area, rim area, average and vertical cup/disc (C/D) ratio, and cup volume were not significantly different between the study groups. The average and 4-quadrant retinal nerve fiber layer (RNFL) measurements of the C/D >0.3 subgroups were not significantly different in the patients and controls. These values were also similar for the C/D >0.5 subgroups except that the average inferior quadrant RNFL thickness of the right eyes in the patient subgroup was significantly thinner than in the control subgroup (p<0.05). Conclusions Our SSc cohort had relatively shorter disease duration but increased prevalence of early glaucomatous damage signs. Our findings indicate that SSc is a risk factor for developing normal-tension glaucoma. Further studies combined with visual field evaluation are necessary to identify the long-term glaucomatous effects of SSc.

Retinal Optical Coherence Tomography Metrics Are Unchanged in Verubecestat Alzheimer’s Disease Clinical Trial but Correlate with Baseline Regional Brain Atrophy

2021 ◽  
Vol 79 (1) ◽  
pp. 275-287
Author(s):  
Robert C. Sergott ◽  
Annaswamy Raji ◽  
James Kost ◽  
Cyrille Sur ◽  
Saheeda Jackson ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Brain Atrophy ◽  
Retinal Thickness ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

Background: We performed exploratory analyses of retinal thickness data from a clinical trial of the AβPP cleaving enzyme (BACE) inhibitor verubecestat in patients with Alzheimer’s disease (AD). Objective: To evaluate: 1) possible retinal thickness changes following BACE inhibition; and 2) possible association between retinal thickness and brain atrophy. Methods: Retinal thickness was measured using spectral-domain optical coherence tomography in a 78-week randomized placebo-controlled trial of verubecestat in 1,785 patients with mild-to-moderate AD. Changes from baseline in retinal pigment epithelium, macular grid retinal nerve fiber layer, central subfield retinal thickness, and macular grid volume were evaluated for verubecestat versus placebo. Correlation analyses were performed to investigate the potential association between macular grid retinal nerve fiber layer and central subfield retinal thickness with brain volumetric magnetic resonance imaging (vMRI) data at baseline, as well as correlations for changes from baseline at Week 78 in patients receiving placebo. Results: Verubecestat did not significantly alter retinal thickness during the trial compared with placebo. At baseline, mean macular grid retinal nerve fiber layer and central subfield retinal thickness were weakly but significantly correlated (Pearson’s r values≤0.23, p-values < 0.01) with vMRI of several brain regions including whole brain, hippocampus, and thalamus. At Week 78, correlations between retinal thickness and brain vMRI changes from baseline in the placebo group were small and mostly not statistically significant. Conclusion: BACE inhibition by verubecestat was not associated with adverse effects on retinal thickness in patients with mild-to-moderate AD. Correlations between retinal thickness and brain volume were observed at baseline. Trial registration: Clinicaltrials.gov NCT01739348 (registered December 3, 2012; https://clinicaltrials.gov/ct2/show/NCT01739348).

scholarly journals Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography

2011 ◽  
Vol 19 (11) ◽  
pp. 10252 ◽  
Author(s):  
Badr Elmaanaoui ◽  
Bingqing Wang ◽  
Jordan C. Dwelle ◽  
Austin B. McElroy ◽  
Shuang S. Liu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Swept Source ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber
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