Single Intravitreal Aflibercept Injection for Unilateral Acute Nonarteritic Ischemic Optic Neuropathy

Acute nonarteritic ischemic optic neuropathy (ANAION) is the most common optic neuropathy in the elderly population without a well-established treatment. A 67-year-old man with a sudden painless visual loss in his left eye of one-day duration was diagnosed to have left ANAION. Next day, 2 mg aflibercept injection was injected intravitreally in OS. Visual acuity improved to 7/10 from 1/10 a week after the injection. Mean retinal nerve fiber layer thickness (RNFLT) was reduced to 159,7 μm from 182,4 μm at the first week. Visual fields improved dramatically during the follow-up of three months. The aim of this study is to present a case having ANAION treated with a single intravitreal aflibercept injection and discuss the place of intravitreal anti-VEGF injections in the treatment of armamentarium of ANAION.

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Comparison of the Correlations Between Optic Disc Rim Area and Retinal Nerve Fiber Layer Thickness in Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy

Yearbook of Ophthalmology ◽

10.1016/j.yoph.2011.06.032 ◽

2011 ◽

Vol 2011 ◽

pp. 194-195

Author(s):

R.C. Sergott

Keyword(s):

Nerve Fiber ◽

Layer Thickness ◽

Optic Disc ◽

Optic Neuropathy ◽

Retinal Nerve Fiber Layer ◽

Ischemic Optic Neuropathy ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

Optic Disc Rim Area

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Retinal Nerve Fiber Layer Thickness by Stratus and Cirrus OCT in Retrobulbar Optic Neuritis and Nonarteritic Ischemic Optic Neuropathy

European Journal of Ophthalmology ◽

10.5301/ejo.5000822 ◽

2016 ◽

Vol 27 (1) ◽

pp. 80-85 ◽

Cited By ~ 2

Author(s):

Barbara Giambene ◽

Gianni Virgili ◽

Ugo Menchini

Keyword(s):

Confidence Interval ◽

Optic Neuritis ◽

Nerve Fiber ◽

Layer Thickness ◽

Optic Neuropathy ◽

Ischemic Optic Neuropathy ◽

Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

Cirrus Oct ◽

Retrobulbar Optic Neuritis

Purpose To compare retinal nerve fiber layer thickness (RNFLT) measurements by Stratus and Cirrus optical coherence tomography (OCT) and to evaluate agreement between the 2 instruments in retrobulbar optic neuritis (RON), nonarteritic ischemic optic neuropathy (NAION), and healthy controls. Methods A total of 89 eyes with RON, 92 with NAION (6 to 12 months after diagnosis of acute disease), and 159 control eyes were studied. Average RNFLT was measured by Stratus and Cirrus OCTs. Comparisons among groups were performed by analysis of variance. Agreement between the 2 instruments was assessed using intraclass correlation coefficient (ICC) with 95% confidence interval (CI) and Bland-Altman analysis. Statistical significance was set at p≤0.05. Results Average RNFLT was lower in NAION eyes than in RON and control ones using both OCT devices (60.0 ± 1.2, 69.9 ± 1.2, and 97.4 ± 0.9 μm, p<0.001 by Cirrus; 49.7 ± 1.5, 65.9 ± 1.9, and 99.2 ± 1.3 μm, p<0.001 by Stratus). The RNFLT values were higher with Cirrus than with Stratus in NAION (+10.30 μm, confidence interval [CI] 7.82-12.79 μm) and RON (+4.01 μm, CI 1.32-6.70 μm) eyes, and slightly lower in control ones (-1.75 μm, CI -3.51 to 0.01 μm). A stronger agreement between the 2 instruments was found in control and RON eyes than in NAION ones (ICC 0.682, CI 0.566-0.771; 0.635, CI 0.467-0.758; 0.321, CI 0.132-0.472, respectively). Conclusions Both Stratus and Cirrus OCT can identify RNFLT reduction in previous RON and NAION. Absolute RNFLT values differ between the 2 instruments; hence they are not to be considered interchangeable.

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