scholarly journals Visual Fields at Follow-up in the Ischemic Optic Neuropathy Decompression Trial

Ophthalmology ◽  
2008 ◽  
Vol 115 (10) ◽  
pp. 1809-1817 ◽  
Author(s):  
Roberta W. Scherer ◽  
Steven E. Feldon ◽  
Lori Levin ◽  
Patricia Langenberg ◽  
Joanne Katz ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Visual Fields ◽  
Ischemic Optic Neuropathy

scholarly journals Single Intravitreal Aflibercept Injection for Unilateral Acute Nonarteritic Ischemic Optic Neuropathy

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ziya Ayhan ◽  
Gamze Kocaoğlu ◽  
Aylin Yaman ◽  
Meltem Söylev Bajin ◽  
A. Osman Saatci
Keyword(s):  
Optic Neuropathy ◽  
Elderly Population ◽  
Visual Fields ◽  
The Elderly ◽  
Ischemic Optic Neuropathy ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Intravitreal Aflibercept ◽  
Established Treatment

Acute nonarteritic ischemic optic neuropathy (ANAION) is the most common optic neuropathy in the elderly population without a well-established treatment. A 67-year-old man with a sudden painless visual loss in his left eye of one-day duration was diagnosed to have left ANAION. Next day, 2 mg aflibercept injection was injected intravitreally in OS. Visual acuity improved to 7/10 from 1/10 a week after the injection. Mean retinal nerve fiber layer thickness (RNFLT) was reduced to 159,7 μm from 182,4 μm at the first week. Visual fields improved dramatically during the follow-up of three months. The aim of this study is to present a case having ANAION treated with a single intravitreal aflibercept injection and discuss the place of intravitreal anti-VEGF injections in the treatment of armamentarium of ANAION.

scholarly journals The anterior ischemic optic neuropathy treatment using the dispersed “Alloplant”

2013 ◽  
Vol 6 (2) ◽  
pp. 20-24
Author(s):  
Venera Uzbekovna Galimova ◽  
Irina Viktorovna Verzakova ◽  
Yevgeniy Musinovich Gareyev ◽  
Zarina Khikhmetullovna Karimova
Keyword(s):  
Visual Acuity ◽  
Visual Field ◽  
Blood Supply ◽  
Optic Neuropathy ◽  
Visual Fields ◽  
Resistance Index ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Ciliary Arteries ◽  
Lateral Branches

In this article, the results of a study are presented on the influence of the therapeutic retroscleral filling by dispersed “Alloplant” biomaterial upon blood supply and visual functions of the eye. 47 patients (69 eyes) suffering from anterior ischemic optic neuropathy sequelae were examined. Obtained results allowed to study the degree of relationship between the following indices: resistance index of ocular vessels, visual acuity and electrophysiological data, visual field limits. The majority of cases with significant visual fields widening (79 %) correlated with post-operative decrease of resistance index in posterior short ciliary arteries (medial and lateral branches). The results of performed investigation allow to assume that the dispersed “Alloplant” biomaterial use in the treatment of patients with anterior ischemic optic neuropathy sequelae could promote the optic nerve blood supply improvement with further amelioration of visual function indices.

scholarly journals AZATHIOPRINE INDUCED PANCYTOPENIA-A CASE REPORT

2017 ◽  
Vol 9 (2) ◽  
pp. 324 ◽  
Author(s):  
Jeslyn Mary Philip ◽  
Parvathypriya C. ◽  
Christeena George ◽  
Meenu Vijayan
Keyword(s):  
Optic Neuropathy ◽  
Tpmt Activity ◽  
Ischemic Optic Neuropathy ◽  
Normal Range ◽  
Total Blood ◽  
Oral Steroids ◽  
Low Levels ◽  
Severe Pancytopenia ◽  
Stimulating Factor

<p>Azathioprine (AZA), a prodrug of 6 mercaptopurine, is an immunosuppressant that can be used as adjunctive therapy with corticosteroids in the treatment of arteritic form of ischemic optic neuropathy. Although myelotoxicity is known to occur while using azathioprine, severe pancytopenia is rarely seen. Patients with thiopurine methyltransferase (TPMT) deficiency are at high risk of developing severe myelosuppression. A 63 year* old female with ischemic optic neuropathy was initiated treatment with oral methylprednisone. As two courses of oral steroids showed no significant improvement, oral azathioprine 25 mg twice daily was added and gradually increased to 50 mg twice daily with relief of symptoms. 6 mo later, she was admitted with acute stroke and lab reports showed low levels of total blood counts or pancytopenia. The patient was put on broad spectrum antibiotics; given injection of granulocyte colony stimulating factor 300 mcg subcutaneously and blood transfusion as correction till counts normalised. She improved over 14 d and on next follow-up counts were in normal range. Causality was assessed by Naranjo causality assessment scale and a probable relationship was obtained between azathioprine and pancytopenia with a score of 6. Variations in TPMT activity occurs due to genetic polymorphism. Physicians should be aware of the possibility of myelosuppression while prescribing azathioprine. Frequent blood count monitoring is the most convenient way to avoid this problem where testing for TPMT deficiency is not possible.</p>

Anterior and posterior ischemic optic neuropathy following liposuction surgery in a previously healthy young woman

2020 ◽  
pp. 112067212096206
Author(s):  
Kaveh Abri Aghdam ◽  
Ali Sadeghi ◽  
Mostafa Soltan Sanjari ◽  
Ali Aghajani ◽  
Saba Gholamalizadeh
Keyword(s):  
Optic Neuropathy ◽  
Vision Loss ◽  
Ischemic Optic Neuropathy ◽  
Laboratory Studies ◽  
Level Of Evidence ◽  
Healthy Young Woman ◽  
Posterior Ischemic Optic Neuropathy ◽  
The Right ◽  
Liposuction Surgery

A previously healthy 28-year-old female developed bilateral painless vision loss, more prominent in the right eye than in the left, following abdominoplasty and liposuction surgery. Laboratory studies showed severe peri- and post-operative anemia. Over a 5-month follow-up, visual function remained decreased but stable in the right eye and improved in the left eye. This is the second reported case of anterior ischemic optic neuropathy in one eye and posterior ischemic optic neuropathy in the other eye after liposuction. Level of evidence: Level VI, case report study.

Bilateral Ischemic Optic Neuropathy Following Intravenous Immunoglobulin

2019 ◽  
Vol 3 (2) ◽  
pp. 111-113
Author(s):  
Waseem H. Ansari ◽  
Brittany K. Patrick ◽  
Bradley T. Smith
Keyword(s):  
Risk Factors ◽  
Visual Acuity ◽  
Intravenous Immunoglobulin ◽  
Optic Neuropathy ◽  
Temporal Relationship ◽  
Ischemic Optic Neuropathy ◽  
Ivig Infusion ◽  
Minimal Improvement ◽  
Contralateral Eye

Purpose: The purpose of this work is to report an association between intravenous immunoglobulin (IVIG) infusions and the development of bilateral ischemic optic neuropathy. Methods: A case report is described. Results: A 76-year-old male receiving IVIG infusions developed loss of vision in the left eye and was diagnosed with ischemic optic neuropathy. Two months later, he developed another episode of ischemic optic neuropathy in the contralateral eye. The investigation for giant-cell arteritis, vasculopathy, and infiltrative processes was negative. The patient had minimal improvement in visual acuity over several months of follow-up. Conclusions: Bilateral ischemic optic neuropathy was likely caused by IVIG infusion in this case, given the temporal relationship and the negative workup for other risk factors.

scholarly journals Follow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography angiography

2020 ◽  
Author(s):  
Juejun Liu ◽  
Changzheng Chen ◽  
Li Lu ◽  
Zuohuizi Yi ◽  
Hongmei Zheng
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Neuropathy ◽  
Optical Coherence Tomography Angiography ◽  
Vessel Density ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Optical Coherence ◽  
Significant Difference ◽  
Sd Oct

Abstract Background To analyze the blood flow changes of radial peripapillary capillaries (RPC) and macula with time procession in patients with non-arteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCT-A).Methods A total of 21 affected eyes and 19 unaffected eyes from 21 NAION patients, and 40 eyes of 20 healthy individuals were included. Assessments of BCVA, CFP, SD-OCT, and OCT-A were performed on NAION patients at enrollment and at 1-2 weeks, 1-2 months, and 3-6 months post-enrollment. Measures of the thickness of peripapillary retinal nerve fiber layer (wRNFL) and macular ganglion cell complex (wGCC) of the whole image in SD-OCT, vessel density of RPC (wRPC) and superficial and deep vascular complexes (wSVD, wDVD) in the whole image of OCT-A, and their superior- and inferior-hemi values (s/iRNFL, s/iGCC, s/iRPC, and s/iSVD) were assessed.Results Compared to healthy controls, wRPC (p<0.001) and wDVD (P=0.001) were significantly lower in affected eyes at baseline, and there was no significant difference in wSVD (p>0.05). The wRPC and wSVD values of affected eyes were significantly decreased at follow-up time points of 1-2 and 3-6 months compared to baseline (p=0.001, p=0.000; p=0.000, p=0.000). The sRPC values were significantly lower than iRPC at 1-2/3-6 months (p=0.001, p=0.000), and sSVD values were lower than iSVD at 1-2 months (p=0.010). Statistically significant correlations were found between wRPC and wRNFL values at 3-6 months (r=0.626, p=0.022), between wSVD and wGCC at 1-2 weeks and 1-2 months (r=0.570, r=0.436; p=0.007, p=0.048).Conclusion OCT-A revealed a sectorial reduction in vessel density in RPC and macula with the disease progression of NAION from acute to atrophic stages, a classification associated with structural deficits.

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