Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature

Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported in the literature, with only one of them being intrathyroidal. Here we report a case of a 34-year-old woman who presented for evaluation of a goiter and was found to have a thyroid nodule and abnormal thyroid function tests (TFT). Fine needle aspiration biopsy of the nodule revealed thyroid follicular cells without atypia and subsequent Afirma® Gene Expression Classifier (GEC) testing results were suspicious for malignancy. As a result, the patient underwent a right thyroid lobectomy and isthmusectomy. Histological sections revealed an intrathyroidal nodule consistent with a clear cell neoplasm of parathyroid origin. The histologic appearance together with the immune profile was diagnostic of WCCA, with diffuse positivity for GATA3, focal weak positivity for parathyroid hormone, and negativity for PAX8, thyroglobulin, TTF1, synaptophysin, chromogranin, and S100p. Our study focuses on the clinical presentation, current management strategies, and review of the available literature surrounding this rare diagnosis. The ultimate goal is to help endocrinologists and surgeons establish a foundational treatment plan for intrathyroidal clear cell tumor cases.

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Clear cell tumor of the lung Could Be Aggressive: a case report and review of the literature

10.21203/rs.3.rs-17141/v1 ◽

2020 ◽

Author(s):

leilei shen ◽

Jixing LIN ◽

Zhipeng REN ◽

Bailin WANG ◽

You Liu ◽

...

Keyword(s):

Fine Needle Aspiration Biopsy ◽

Clear Cell ◽

Mediastinal Lymph Node ◽

Lower Lobe ◽

Needle Aspiration ◽

Cell Tumor ◽

Epithelioid Cells ◽

Case Presentation ◽

Clear Cell Tumor ◽

Pulmonary Neoplasm

Abstract Background: Clear cell tumor of the lung (CCTL) is a rare and mostly benign pulmonary neoplasm arising from perivascular epithelioid cells. Only about 100 cases have been reported and half of them were in China. Limited details about CCTL often cause diagnostic or therapeutic problems. Case presentation: We describe a case of 28-year-old woman with gradually increased and enlarged multiple nodules in the left lower lobe. The patient underwent a fine-needle aspiration biopsy and was considered as CCTL. A left lower lobectomy and mediastinal lymph node dissection was performed. The gradual changes in size (1.4 cm to 2.8 cm) and quantity (10 to 49) of CCTL in this case was the biggest difference from previously reported cases. Conclusions: CCTL is a very uncommon and mostly benign PEComatous tumor with no specific morphologic features. We present a case of CCTL with multiplicity and rapid growth, which may indicate its aggressive nature. The accumulation of similar cases will help clarify its exact disease nature and to improve our understanding of such tumor.

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Ovarian Clear Cell Tumor

10.32388/haaajd ◽

2020 ◽

Author(s):

Keyword(s):

Clear Cell ◽

Cell Tumor ◽

Clear Cell Tumor

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A rare cause of hemoptysis: benign sugar (clear) cell tumor of the lung

European Journal of Cardio-Thoracic Surgery ◽

10.1016/j.ejcts.2004.01.022 ◽

2004 ◽

Vol 25 (4) ◽

pp. 652-654 ◽

Cited By ~ 28

Author(s):

A SANTANA ◽

F NUNES ◽

N HO ◽

T TAKAGAKI

Keyword(s):

Clear Cell ◽

Cell Tumor ◽

Clear Cell Tumor

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A Clear Cell Tumor of the Lung Presenting as a Rapidly Growing Coin Lesion: Is It Really a Benign Tumor?

The Annals of Thoracic Surgery ◽

10.1016/j.athoracsur.2010.07.043 ◽

2011 ◽

Vol 91 (2) ◽

pp. 588-591 ◽

Cited By ~ 6

Author(s):

Alexandros Kalkanis ◽

Myrto Trianti ◽

Kostas Psathakis ◽

Charalampos Mermigkis ◽

Dimitrios Kalkanis ◽

...

Keyword(s):

Benign Tumor ◽

Clear Cell ◽

Cell Tumor ◽

Clear Cell Tumor ◽

Coin Lesion

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Clear Cell Tumor of the Colon in an 8.5-Year-Old Girl

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/00005176-200108000-00019 ◽

2001 ◽

Vol 33 (2) ◽

pp. 196-199

Author(s):

Vicky Zolota ◽

Anna Batistatou ◽

Maria Melachrinou ◽

Evangelos Tzorakoeleftherakis ◽

Vassilios Pastromas ◽

...

Keyword(s):

Clear Cell ◽

Cell Tumor ◽

Clear Cell Tumor

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Unusual clear cell tumor of the kidney in infancy

The American Journal of Surgical Pathology ◽

10.1097/00000478-198109000-00007 ◽

1981 ◽

Vol 5 (6) ◽

pp. 581-586 ◽

Cited By ~ 3

Author(s):

Alan D. Glick ◽

Kyi Toe Tham ◽

Nai Kwong Leung ◽

Song Win Wong

Keyword(s):

Clear Cell ◽

Cell Tumor ◽

Clear Cell Tumor

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Lung Clear “Sugar” Cell Tumor and Jak V617f Positive Essential Thrombocythemia: A simple Coıncıdence?

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2013.021 ◽

2013 ◽

Vol 5 (1) ◽

pp. e2013021

Author(s):

Volkan Yazak ◽

Gokhan Sargin ◽

Irfan Yavasoglu ◽

Gurhan Kadikoylu ◽

Canten Tataroglu ◽

...

Keyword(s):

Essential Thrombocythemia ◽

Clear Cell ◽

Cell Tumor ◽

Myeloproliferative Disease ◽

Laboratory Findings ◽

Clear Cell Tumor ◽

Distinct Cell ◽

Sugar Tumor ◽

Rare Benign Tumor ◽

Clear Cytoplasm

The primary clear cell tumor of the lung is an extremely rare benign tumor, which is called “sugar tumor”, because of the large content of glycogen. Here we are presenting essential thrombocythemia and lung clear cell tumor which was not reported before to the best of our knowledge.A 44 years old woman admitted to the clinic with complaint of lassitude lasting for 2 months. In her physical examination the spleen was 3 cm palpable from the costa arch In laboratory findings number of platelet was 1014000 mm³. A 3.5 cm in diameter pulmonary nodule is detected in right upper lobe in the graphy of the lungs. Subsequently computed tomography (CT ) of thorax was carried out. Due to the benign features in the display of the detected nodule, a total excision with curative and diagnostic intentions was performed. Microscopically the tumor were composed of nests of rounded or oval cells with distinct cell borders and optically clear cytoplasm. The nuclei were small. Immunohistochemically the tumor cells expressed HMB-45, NSE and focal S100 antigen. It was diagnosed as clear “sugar” cell tumor. In conclusion, in lung clear cell tumor, it is important to make evaluation in terms of myeloproliferative disease in adults whose thrombocytosis continue after the treatment.

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