scholarly journals Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with 82Rb PET

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Adrian F. Ocneanu ◽  
Robert A. deKemp ◽  
Jennifer M. Renaud ◽  
Andy Adler ◽  
Rob S. B. Beanlands ◽  
...  
Keyword(s):  
Blood Flow ◽  
Kinetic Model ◽  
Myocardial Blood Flow ◽  
Input Function ◽  
Blood Pool ◽  
Flow Measurements ◽  
Flow Reserve ◽  
Arterial Blood ◽  
Spillover Correction ◽  
Blood Flow Measurements

Purpose. Myocardial blood flow (MBF) quantification with Rb82 positron emission tomography (PET) is gaining clinical adoption, but improvements in precision are desired. This study aims to identify analysis variants producing the most repeatable MBF measures. Methods. 12 volunteers underwent same-day test-retest rest and dipyridamole stress imaging with dynamic Rb82 PET, from which MBF was quantified using 1-tissue-compartment kinetic model variants: (1) blood-pool versus uptake region sampled input function (Blood/Uptake-ROI), (2) dual spillover correction (SOC-On/Off), (3) right blood correction (RBC-On/Off), (4) arterial blood transit delay (Delay-On/Off), and (5) distribution volume (DV) constraint (Global/Regional-DV). Repeatability of MBF, stress/rest myocardial flow reserve (MFR), and stress/rest MBF difference (ΔMBF) was assessed using nonparametric reproducibility coefficients (RPCnp = 1.45 × interquartile range). Results. MBF using SOC-On, RVBC-Off, Blood-ROI, Global-DV, and Delay-Off was most repeatable for combined rest and stress: RPCnp = 0.21 mL/min/g (15.8%). Corresponding MFR and ΔMBF RPCnp were 0.42 (20.2%) and 0.24 mL/min/g (23.5%). MBF repeatability improved with SOC-On at stress (p<0.001) and tended to improve with RBC-Off at both rest and stress (p<0.08). DV and ROI did not significantly influence repeatability. The Delay-On model was overdetermined and did not reliably converge. Conclusion. MBF and MFR test-retest repeatability were the best with dual spillover correction, left atrium blood input function, and global DV.

scholarly journals Effect of temporal sampling protocols on myocardial blood flow measurements using Rubidium-82 PET

2021 ◽  
Author(s):  
S. S. Koenders ◽  
J. D. van Dijk ◽  
P. L. Jager ◽  
M. Mouden ◽  
A. G. Tegelaar ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Flow Measurements ◽  
Temporal Sampling ◽  
Flow Reserve ◽  
Sampling Protocols ◽  
Blood Flow Measurements ◽  
Time Frames ◽  
Tissue Phase ◽  
Rubidium 82

Abstract Background A variety of temporal sampling protocols is used worldwide to measure myocardial blood flow (MBF). Both the length and number of time frames in these protocols may alter MBF and myocardial flow reserve (MFR) measurements. We aimed to assess the effect of different clinically used temporal sampling protocols on MBF and MFR quantification in Rubidium-82 (Rb-82) PET imaging. Methods We retrospectively included 20 patients referred for myocardial perfusion imaging using Rb-82 PET. A literature search was performed to identify appropriate sampling protocols. PET data were reconstructed using 14 selected temporal sampling protocols with time frames of 5-10 seconds in the first-pass phase and 30-120 seconds in the tissue phase. Rest and stress MBF and MFR were calculated for all protocols and compared to the reference protocol with 26 time frames. Results MBF measurements differed (P ≤ 0.003) in six (43%) protocols in comparison to the reference protocol, with mean absolute relative differences up to 16% (range 5%-31%). Statistically significant differences were most frequently found for protocols with tissue phase time frames < 90 seconds. MFR did not differ (P ≥ 0.11) for any of the protocols. Conclusions Various temporal sampling protocols result in different MBF values using Rb-82 PET. MFR measurements were more robust to different temporal sampling protocols.

Image-Based Measurements of Myocardial Blood Flow

2015 ◽  
Author(s):  
Heinrich R. Schelbert
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Structural Changes ◽  
Large Body ◽  
Treatment Strategies ◽  
Flow Measurements ◽  
Time Activity ◽  
Flow Reserve ◽  
Coronary Stenoses ◽  
Functional Consequences

Image-based measurements of myocardial blood flow afford the assessment of coronary circulatory function. They reflect functional consequences of coronary stenoses, diffuse epicardial vessel disease and microvascular dysfunction and structural changes and thus provide a measure of the total ischemic burden. Measured flows contain therefore clinically important predictive information. Fundamental to flow measurements are the tissue tracer kinetics, their description through tracer kinetic models, high spatial and temporal resolution imaging devices and accurate extraction of radiotracer tissue concentrations from dynamically acquired images for estimating true flows from the tissue time activity curves. A large body of literature on measurements of myocardial blood flow exists for defining in humans normal values for flow at baseline and during hyperemic stress as well as for the myocardial flow reserve. The role of PET for flow measurements has been well established; initial results with modern SPECT devices are encouraging. Responses of myocardial blood flow to specific challenges like pharmacologic vasodilation and to sympathetic stimulation can uncover functional consequences of focal epicardial coronary stenoses, of conduit vessel disturbances and disease and impairments of microvascular function. Apart from risk stratification, flow measurements may allow detection of early preclinical disease, influence treatment strategies and identify therapy responses.

Comparison between regional myocardial blood flow measurements and results of exercise tests

1977 ◽  
Vol 3 (4) ◽  
pp. 359-366 ◽  
Author(s):  
Barbara H. Roberts ◽  
Peter F. Cohn ◽  
B. Leonard Holman ◽  
Douglass F. Adams ◽  
Jackie R. See
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Regional Myocardial Blood Flow ◽  
Exercise Tests ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
Regional Myocardial Blood

The impact of prompt gamma compensation on myocardial blood flow measurements with rubidium-82 dynamic PET

2016 ◽  
Vol 25 (2) ◽  
pp. 596-605 ◽  
Author(s):  
Ian S. Armstrong ◽  
Matthew J. Memmott ◽  
Christine M. Tonge ◽  
Parthiban Arumugam
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Prompt Gamma ◽  
Dynamic Pet ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
The Impact ◽  
Rubidium 82

Assessment of arterial blood flow measurements by digital angiography.

Radiology ◽  
1981 ◽  
Vol 141 (1) ◽  
pp. 39-47 ◽  
Author(s):  
J H Bürsch ◽  
H J Hahne ◽  
R Brennecke ◽  
D Grönemeier ◽  
P H Heintzen
Keyword(s):  
Blood Flow ◽  
Arterial Blood Flow ◽  
Digital Angiography ◽  
Flow Measurements ◽  
Arterial Blood ◽  
Blood Flow Measurements

Increased number of myocardial blood flow measurements with radionuclide-labeled microspheres

1984 ◽  
Vol 246 (3) ◽  
pp. H418-H434 ◽  
Author(s):  
R. W. Baer ◽  
B. D. Payne ◽  
E. D. Verrier ◽  
G. J. Vlahakes ◽  
D. Molodowitch ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Least Squares ◽  
Reference Sample ◽  
Separation Technique ◽  
Fixed Amount ◽  
Flow Measurements ◽  
Coronary Pressure ◽  
Blood Flow Measurements

We evaluated the use of a least-squares radionuclide separation technique to allow an increased number of myocardial blood flow measurements with radionuclide-labeled microspheres in dogs. Two sets of labeled microspheres were studied: a set of eight labeled with 125I, 153Gd, 57Co, 51Cr, 113Sn, 85Sr, 95Nb, and 46Sc; and a set of nine in which 125I and 46Sc were replaced with 114In, 54Mn, and 65Zn. For each microsphere label the nuclide activities determined by least-squares separation compared favorably with those actually added to in vitro samples containing a fixed amount of the other nuclides in the set. For the set of eight radionuclide-labeled microspheres, myocardial flow measurements made with the least-squares separation technique and the reference sample method were usually within 15% and almost all within 20% of direct measurements of coronary venous outflow in a right heart bypass preparation. Serial left atrial injections of 15-micron microspheres totaling 48 X 10(6) caused no significant changes in systemic hemodynamics, regional myocardial flows, or coronary pressure-flow relations, whether the coronary bed was autorelating or vasodilated with chromonar. We conclude that at least nine myocardial blood flow measurements can be made in dogs with acceptable accuracy and without evidence of dysfunction due to embolization of the coronary vascular bed. With appropriate validation, this method should be applicable to other organs and animal models as well.

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