The air pollution tradeoff in India: Saving more lives versus reducing the inequality of exposure

Chronic exposure to ambient fine particulate matter (PM2.5) represents one of the largest global public health risks, leading to millions of premature deaths annually. For a country facing high and spatially variable exposures, prioritizing where to reduce PM2.5 concentrations leads to an inherent tradeoff between saving the most lives and reducing inequality of exposure. This tradeoff results from the shape of the concentration-response function between exposure to PM2.5 and mortality, which indicates that the additional lives saved per unit reduction in PM2.5 declines as concentrations increase. We estimate this concentration-response function for urban areas of India, finding that a 10 unit reduction in PM2.5 in already-clean locations will reduce the mortality rate substantially (4.2% for a reduction from 30 to 20 µgm-3), while a 10 unit reduction in the dirtiest locations will reduce mortality only modestly (1.2% for a reduction from 90 to 80 µgm-3). We explore the implications of this PM2.5/mortality relationship by considering a thought experiment. If India had a fixed amount of resources to devote to PM2.5 concentration reductions across urban areas, what is the lives saved/inequality of exposure tradeoff from three different methods of employing those resources? Across our three scenarios—1) which reduces exposures for the dirtiest districts, 2) which reduces exposures everywhere equally, and 3) which reduces exposures to save the most lives—scenario 1 saves 18,000 lives per year while reducing the inequality of exposure by 65%, while scenario 3 saves 126,000 lives per year, but increases inequality by 19%.

Choice Bundling Increases Valuation of Delayed Losses More Than Gains in Cigarette Smokers

Choice bundling, in which a single choice produces a series of repeating consequences over time, increases valuation of delayed monetary and non-monetary gains. Interventions derived from this manipulation may be an effective method for mitigating the elevated delay discounting rates observed in cigarette smokers. No prior work, however, has investigated whether the effects of choice bundling generalize to reward losses. In the present study, an online panel of cigarette smokers (N = 302), recruited using survey firms Ipsos and InnovateMR, completed assessments for either monetary gains or losses (randomly assigned). In Step 1, participants completed a delay-discounting task to establish Effective Delay 50 (ED50), or the delay required for an outcome to lose half of its value. In Step 2, participants completed three conditions of an adjusting-amount task, choosing between a smaller, sooner (SS) adjusting amount and a larger, later (LL) fixed amount. The bundle size (i.e., number of consequences) was manipulated across conditions, where a single choice produced either 1 (control), 3, or 9 consequences over time (ascending/descending order counterbalanced). The delay to the first LL amount in each condition, as well as the intervals between all additional SS and LL amounts (where applicable), were set to individual participants’ ED50 values from Step 1 to control for differences in discounting of gains and losses. Results from Step 1 showed significantly higher ED50 values (i.e., less discounting) for losses compared to gains (p < 0.001). Results from Step 2 showed that choice bundling significantly increased valuation of both LL gains and losses (p < 0.001), although effects were significantly greater for losses (p < 0.01). Sensitivity analyses replicated these conclusions. Future research should examine the potential clinical utility of choice bundling, such as development of motivational interventions that emphasize both the bundled health gains associated with smoking cessation and the health losses associated with continued smoking.

Surface Chemistry Study of the Interactions of Sesame Oil with Meibomian Films

A possible approach for the treatment of meibomian gland disease (MGD) can be the supplementation of meibomian gland secretion (MGS) with nonpolar lipids (NPL) rich plant oils. Sesame oil (SO), approximately equal in monounsaturated fat (oleic acid, 40% of total) and polyunsaturated fat (linoleic acid, 42% of total), has shown multiple health benefits due to its anti-inflammatory and antioxidant effects. Thus, the interactions between SO and MGS in surface layers deserve further study. Therefore, pseudobinary films were formed with controlled MGS/SO molar ratios (0%, 10%, 30%, 50%, and 100% SO) at the air/water surface of the Langmuir trough over phosphate buffered saline (pH 7.4) subphase. Surface pressure (π)-area (A) isotherms and Brewster angle microscopy observations showed nonideal interactions where SO aggregates with MGS and complements the NPL stratum of the meibomian layers. The analysis of stress relaxation transients with Kohlrausch–Williams–Watts equation revealed that the supplementation of fixed amount of MGS with excess lipids via SO altered the dilatational elasticity of the films as reflected by the increase of the exponent β. Thus, SO with its unique combination of high oxidative stability and abundance of long polyunsaturated acyl chains might be a useful supplement to MGS layers.

The Interactions and Release Kinetics of Sodium Hyaluronate Implemented in Nonionic and Anionic Polymeric Hydrogels, Studied by Immunoenzymatic ELISA Test

Hyaluronan is a natural polymer that was introduced to wound therapy. Formulations based on synthetic polymers such as methylcellulose (MC) and polyacrylic acid (PA) containing hyaluronan (HA) were proposed for the development of prospective wound-healing preparations. The formulations of different carrier concentrations containing a fixed amount of HA were prepared, and their viscosity was measured. The HA release was evaluated by employing the apparatus paddle over a disc. The hydrogels were introduced to the donor chamber, and HA was released to the pH = 7.4 buffer. The amount of HA released was obtained using the ELISA test. The release was analyzed on the basis of different kinetic models: zero-, first-, and second-order kinetics, as well as Higuchi and Korsmeyer–Peppas equations. The release rate constants and the half release time were calculated from these equations. According to the value of the coefficient of the determination, the best model describing the observed process was selected. The comparison between the dissolution profiles was carried out by calculating the difference factor f1 and the similarity factor f2. The interaction between the hydrogel components was investigated by Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) measurements. The study revealed that the zero-order equation best described the release of HA from the formulations studied. The FTIR research and the DSC study showed the intermolecular interaction between HA chains in MC-based compositions, as well as between HA and the synthetic polymer in the PA-based formulations. The study revealed that the formulation with a higher concentration of synthetic polymer may prolong the release of HA. The obtained results indicated that the proposed hydrogels have potential for wound healing and may accelerate skin regeneration.

A two-sex model of human papillomavirus infection: Vaccination strategies and a case study

Vaccination is effective in preventing human papillomavirus (HPV) infection. It still remains debatable whether males should be included in a vaccination program and unclear how to allocate the vaccine in genders to achieve the maximum benefits. In this paper, we use a two-sex model to assess HPV vaccination strategies and use the data from Guangxi Province in China as a case study. Both mathematical analysis and numerical simulations show that the basic reproduction number, an important indicator of the transmission potential of the infection, achieves its minimum when the priority of vaccination is given to the gender with a smaller recruit rate. Given a fixed amount of vaccine, splitting the vaccine evenly usually leads to a larger basic reproduction number and a higher prevalence of infection. Vaccination becomes less effective in reducing the infection once the vaccine amount exceeds the smaller recruit rate of the two genders. In the case study, we estimate the basic reproduction number is 1.0333 for HPV 16/18 in people aged 15-55. The minimal bivalent HPV vaccine needed for the disease prevalence to be below 0.05% is 24050 per year, which should be given to females. However, with this vaccination strategy it would require a very long time and a large amount of vaccine to achieve the goal. In contrast with allocating the same vaccine amount every year, we find that a variable vaccination strategy with more vaccine given in the beginning followed by less vaccine in later years can save time and total vaccine amount. The variable vaccination strategy illustrated in this study can help to better distribute the vaccine to reduce the HPV prevalence. Although this work is for HPV infection and the case study is for a province in China, the model, analysis and conclusions may be applicable to other sexually transmitted diseases in other regions or countries.

Asymptotic Solutions of a Generalized Starobinski Model: Kinetic Dominance, Slow Roll and Separatrices

We consider a generalized Starobinski inflationary model. We present a method for computing solutions as generalized asymptotic expansions, both in the kinetic dominance stage (psi series solutions) and in the slow roll stage (asymptotic expansions of the separatrix solutions). These asymptotic expansions are derived in the framework of the Hamilton-Jacobi formalism where the Hubble parameter is written as a function of the inflaton field. They are applied to determine the values of the inflaton field when the inflation period starts and ends as well as to estimate the corresponding amount of inflation. As a consequence, they can be used to select the appropriate initial conditions for determining a solution with a previously fixed amount of inflation.

A Novel Polyvinylpyrrolidone-Stabilized Illite Microparticle with Enhanced Antioxidant and Antibacterial Effect

Illite is a clay mineral that shows antioxidant and antibacterial activities because of the abundance of important clay elements in its structure. However, illite has low bioactivity due to its low solubility and electron-donating ability in aqueous solutions. Therefore, we aimed to develop polyvinylpyrrolidone (PVP)-stabilized illite microparticles (P-lite MPs) via polymer adsorption on illite surfaces. An increasing amount of PVP was used to coat a fixed amount of illite to prepare P-lite MPs of different hydrodynamic diameters in the range of 4–9 μm. These sizes were maintained for 2 weeks during storage in a biological buffer without any noticeable changes. The stabilization of illite microparticles using a hydrophilic PVP polymer improved their aqueous dispersity and free radical-scavenging activity. Since the large surface area of microparticles provides several sites for interactions, the smallest P-lite MP exhibited the highest antioxidant and antibacterial activities. More importantly, the MPs showed effective free radical-scavenging activity in vitro without any cytotoxicity. Therefore, P-lite MPs with improved bioavailability may represent a suitable bioactive material for various industrial and biomedical applications.

Processing and Mechanical Behavior of Banana Fibre Reinforced Epoxy based Composite with Alumina and silicon Carbide

Polymer composites have outstanding qualities such as high strength, flexibility, stiffness, and lightweight. Currently, research is being performed to develop innovative polymer composites that may be used in many operational situations and contain a variety of fibre and filler combinations. Banana fibre has low density compared to glass fibre and it is a lingo-cellulosic fibre having relatively good mechanical properties compared to glass fibre. Because of their outstanding qualities, banana fibre reinforced polymer composites are now widely used in various industries. The primary goal of this study is to determine the effect of the wt.% of banana fibre, the wt.% of SiC, and the wt.% of Al2O3 in banana fibre reinforcement composites on the mechanical and physical properties of banana fibre reinforcement composites. Tensile strength and flexural strength of unfilled banana fibre epoxy composite increased with the increase in wt. of banana fibre from 0 wt.% to 12 wt.%. Further, an increase in wt.% banana fibre drop in mechanical property was observed. It has been concluded from the study that the variation in percentage weight of filler material with fixed amount (12 wt.%) of banana fibre affects the mechanical properties of filled banana reinforcement composites. Optimum mechanical properties were obtained for BHEC5 (72 wt.% Epoxy + Hardener, 12 wt.% banana fibre and 16 wt.% Al2O3).

Satellite to Ground Station, Attenuation Prediction for 2.4-72GHz Using LTSM, An Artificial Recurrent Neural Network Technology

Free-space communication is a leading component in global communications. Its advantages relate to a broader signal spread, no wiring, and ease of engagement. Satellite communication services became recently attractive to mega-companies that foresee an excellent opportunity to connect disconnected remote regions, serve emerging machine-to-machine communication, Internet-of-things connectivity, and more. Satellite communication links suffer from arbitrary weather phenomena such as clouds, rain, snow, fog, and dust. In addition, when signals approach the ground station, it has to overcome buildings blocking the direct access to the ground station. Therefore, satellites commonly use redundant signal strength to ensure constant and continuous signal transmission, resulting in excess energy consumption, challenging the limited power capacity generated by solar energy or the fixed amount of fuel. This research proposes LTSM, an artificial recurrent neural network technology that provides a time-dependent prediction of the expected attenuation level due to rain and fog and the signal strength that remained after crossing physical obstacles surrounding the ground station. The satellite transmitter is calibrated accordingly. The satellite outgoing signal strength is based on the predicted signal strength to ensure it will remain strong enough for the ground station to process it. The instant calibration eliminates the excess use of energy resulting in energy savings.

Effect Of Suvarna Bhasma (Gold Calx) On Reproductive System Of Male Albino Rats

Suvarna Bhasma” (gold calx) (SB) prepared as per Ayurveda, a practicing medical system, is prescribed as a medicine in several ailments including conditions like oligozoospermia and asthenoszoospermia in male infertility. SB is prepared from pure metal gold by one of the processing methods detailed in Ayurveda classics. Gold along with other elements was reported in normal human seminal plasma. . In human pathological semen samples, the level of gold was less than normal. Gold may have a role in physiological activity of sperm as shown in case of other elements. The present study supports the hypothesis that the presence of gold is essential for sperm motility. Here we studied the effect of SB on male reproductive organs and semen from epididymis of rat. Present study was performed using Charles foster strain albino rats. Rats were divided into two groups of ten each namely, Group 1 (control) and Group 2 (study). Animals in study group were orally given a fixed amount of SB for 15 days. At the end of the study treated animals showed increase in body weight (<0.05) and testicular weight. In treated animals total sperm count (<0.05) and percentage of sperm motility were increased in epididymal fluid. Histological study showed increase in interstitial area of testes (<0.001), proliferation and branching of the epithelial layer of seminal vesicle. In the Study (gold treated) Group, the increased gold level in genital system may be responsible for the increase in sperm production and motility.