Identification of Underlying Inflammation in Vogt–Koyanagi–Harada Disease with Sunset Glow Fundus by Multiple Analyses

Purpose. To evaluate underlying subclinical ocular inflammation in Vogt–Koyanagi–Harada (VKH) disease with sunset glow fundus (SGF) by multiple analyses. Study Design. Retrospective observational study. Methods. Clinical records of 34 eyes of 17 VKH patients with SGF in whom laser flare photometry (LFP), enhanced depth imaging optical coherence tomography (EDI-OCT), and indocyanine green angiography (ICGA) were performed on the same day were reviewed. The mean age was 57.3 ± 16.3 years, and the mean duration from the initial onset of uveitis was 47.1 ± 22.1 months. Flare counts, ICGA scores, and subfoveal choroidal thickness (SFCT) were compared between eyes. Results. Although clinical ocular inflammation was observed only in 4 eyes (11.8%), inflammatory signs were observed in 23 out of 34 eyes by LFP (67.6%), in 27 eyes by ICGA (79.4%), and in 10 eyes by SFCT (29.4%). Active inflammatory signs detected by ICGA were observed in 77.8% by LFP and in 25.9% by SFCT. The strength of agreement (Cohen’s kappa coefficient) between positive ICGA score and positive flare score was 0.406 (95% CI: 0.076–0.7359, P<0.01), but there was no association between positive ICGA score and increased SFCT. In addition, positive flare count was the significant prognostic factor of positive ICGA score with odds ratio 11.7. Conclusions. Subclinical ocular inflammation signs were detected in most VKH patients with SGF by ICGA and a substantial proportion of which were also detected by LFP, whereas SFCT was less sensitive to detect subclinical inflammation.

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How does nepafenac affect the choroidal thickness after uneventful cataract surgery?

European Journal of Ophthalmology ◽

10.1177/1120672120976041 ◽

2020 ◽

pp. 112067212097604

Author(s):

Selim Cevher ◽

Gülçin Aydoğdu

Keyword(s):

Free Group ◽

Choroidal Thickness ◽

Enhanced Depth Imaging ◽

Depth Imaging ◽

Small Incision ◽

Significant Difference ◽

Ophthalmologic Examination ◽

Imaging Optical Coherence Tomography ◽

The Mean

Purpose: To investigate the effects of topical nepafenac on choroidal thickness (CT) following uneventful phacoemulsification surgery (UPS) using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: This prospective study included 45 randomly selected eyes (23 eyes of 23 patients used nepafenac (nepafenac group) and 22 eyes of 22 control patients did not use nepafenac (nepafenac-free group)) undergoing small-incision UPS. All participants underwent full ophthalmologic examination. CT measurements were performed at subfoveal, 1.0 mm temporal, and 1.0 mm nasal using the EDI-OCT preoperatively, 1 day, 1 week, and 1 month postoperatively. Results: The mean subfoveal, nasal, and temporal CT in the nepafenac-free group had changed from 268.95 ± 63.59 μm to 283.36 ± 65.63 μm, 237.22 ± 64.09 μm to 253.09 ± 67.27 μm, and 235.95 ± 75.22 μm to 259.09 ± 63.66 μm preoperatively to 1 month postoperatively, respectively ( p < 0.001, p < 0.001, p < 0.001, respectively). The mean subfoveal, nasal, and temporal CT in the nepafenac group had changed from 259.65 ± 55.99 μm to 276.65 ± 59.21 μm, 236.34 ± 55.40 μm to 251.00 ± 62.39 μm, and 247.56 ± 50.88 μm to 261.13 ± 53.73 μm preoperatively to 1 month postoperatively, respectively ( p < 0.001, p < 0.001, p < 0.001, respectively). The postoperative CT continued to increase significantly during the follow-up period in two groups. However, compared to the change from baseline to month 1, there was not a statistically significant difference between the groups at subfoveal, nasal, and temporal CT ( p: 0.633, p: 0.865, and p: 0.328, respectively). Conclusion: UPS may cause a significant increase in CT. Although increasing in the CT was lower in the nepafenac group than the nepafenac-free group, there was not a statistically significant difference between the groups.

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Evaluation of the choroidal features in pachychoroid spectrum diseases by optical coherence tomography and optical coherence tomography angiography

European Journal of Ophthalmology ◽

10.1177/1120672119887095 ◽

2019 ◽

pp. 112067211988709 ◽

Cited By ~ 1

Author(s):

Sibel Demirel ◽

Mehmet Fatih Kağan Değirmenci ◽

Figen Batıoğlu ◽

Emin Özmert

Keyword(s):

Optical Coherence Tomography ◽

Central Serous Chorioretinopathy ◽

Optical Coherence Tomography Angiography ◽

Enhanced Depth Imaging ◽

Optical Coherence ◽

Flow Area ◽

Depth Imaging ◽

Imaging Optical Coherence Tomography ◽

The Mean ◽

Pachychoroid Pigment Epitheliopathy

Purpose: To evaluate choroidal area, stroma/lumen ratio, choriocapillaris vessel density, and choriocapillaris flow area in eyes with central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy using enhanced depth imaging-optical coherence tomography and optical coherence tomography angiography. Materials and Methods: This retrospective study analyzed enhanced depth imaging-optical coherence tomography and optical coherence tomography angiography scans of 142 eyes of 92 patients with central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy. The choroidal area and stroma/lumen ratio were measured by binarization of enhanced depth imaging-optical coherence tomography images. Choriocapillaris vessel density and choriocapillaris flow area were measured at the choriocapillaris level by manual segmentation of optical coherence tomography angiography scans. Results: The mean stroma/lumen ratio results were 0.361, 0.345, and 0.354 in central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy groups, respectively ( p > 0.05). The mean whole image choriocapillaris vessel density in uncomplicated pachychoroid group was higher compared with central serous chorioretinopathy and pachychoroid pigment epitheliopathy groups ( p < 0.0001). The mean foveal, parafoveal, and perifoveal choriocapillaris vessel densities were lower in central serous chorioretinopathy group than in uncomplicated pachychoroid group ( p < 0.0001). The mean choriocapillaris flow area was lower in central serous chorioretinopathy group than in uncomplicated pachychoroid and pachychoroid pigment epitheliopathy groups ( p < 0.0001 and p = 0.01, respectively). Conclusion: Our findings suggest that both choroidal vessels and stroma are equally involved in central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy. The choriocapillaris segment seems to be more affected in central serous chorioretinopathy compared to uncomplicated pachychoroid and pachychoroid pigment epitheliopathy. However, the reduced optical coherence tomography angiography signal in central serous chorioretinopathy group could be due to shadowing artifact or choriocapillaris hypoperfusion and further studies with higher quality imaging tools are needed.

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Choroidal Thickness in Lipoid Proteinosis

10.21203/rs.3.rs-769891/v1 ◽

2021 ◽

Author(s):

Armağan Özgür ◽

Isa An

Keyword(s):

Choroidal Thickness ◽

Disease Process ◽

Enhanced Depth Imaging ◽

Control Group ◽

Depth Imaging ◽

Lipoid Proteinosis ◽

Corrected Visual Acuity ◽

Imaging Optical Coherence Tomography ◽

The Mean ◽

Thickness Measurements

Abstract Purpose: To assess choroidal thickness in patients with lipoid proteinosis versus healthy subjects using enhanced depth imaging optical coherence tomography. Methods: 40 eyes of 20 patients and the same number of age and sex-matched healthy individuals were enrolled. Comprehensive ocular examinations including measurement of best-corrected visual acuity, spherical equivalent values of refractive errors, and axial length were performed. Choroidal thickness at three points (subfoveal, 500 µm nasal and temporal regions) were measured. Results: The mean age was 15,68 ± 5,98 years in the patient group and 16,48 ± 5,69 years in the control group. Mean choroidal thickness was statistically significantly thicker at each point in patients with lipoid proteinosis compared to the healthy controls: subfoveal, temporal and nasal choroidal thickness measurements were 414,13 ± 53.88, 359.97 ± 64.75, 322.10 ± 56.74 in the study group; 341.60 ± 42.01, 329.55 ± 41.30, 295.44 ± 43.07 in the control group, respectively ( P < 0.05). Conclusion: Patients with lipoid proteinosis have thicker choroid compared to control eyes. Hyalin deposition and ensuing potential inflammation in the disease process may explain this finding.

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Structural Alterations of the Choroid Evaluated by Enhanced-Depth Imaging Optical Coherence Tomography in Patients with COVID-19

10.21203/rs.3.rs-97433/v1 ◽

2020 ◽

Author(s):

Özkan KOCAMIŞ ◽

Emine Temel ◽

Lokman HIZMALI ◽

Nazife AŞIKGARİP ◽

Kemal ÖRNEK ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Statistical Significance ◽

Enhanced Depth Imaging ◽

Optical Coherence ◽

Depth Imaging ◽

Luminal Area ◽

Imaging Optical Coherence Tomography ◽

The Mean ◽

Group 2 ◽

Group 1

Abstract Background: To assess alterations of choroid by enhanced depth imaging optical coherence tomography (EDI-OCT) in coronavirus disease 2019 (COVID-19).Methods: Thirty-two patients with COVID-19 infection (group 1) and 34 healthy subjects (group 2) were included in this study. The choroidal thickness was measured at three points: Subfoveal, 1500 mm nasal from the fovea, and 1500 mm temporal from the fovea. Total choroidal area, luminal area, stromal area and choroidal vascular index (CVI) was measured by Image-J.Results: In group 1, subfoveal, nasal, and temporal choroid thicknesses were thinner compared to group 2. However, there was no statistical significance (p=0.534, p=0.437, and p=0.077, respectively). The mean total choroidal area, the mean stromal area, the mean luminal area, and the mean CVI were significantly decreased in group 1 (p<0.001, p=0.001, p=0.001, and p=0.003; respectively).Conclusions: Our results demonstrate that there may be choroidal vascular and stromal depletion in these patients.

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Repeatability of choroidal thickness measurements with Spectralis OCT images

BMJ Open Ophthalmology ◽

10.1136/bmjophth-2018-000237 ◽

2019 ◽

Vol 4 (1) ◽

pp. e000237 ◽

Cited By ~ 1

Author(s):

Jason K Lau ◽

Sin Wan Cheung ◽

Michael J Collins ◽

Pauline Cho

Keyword(s):

Choroidal Thickness ◽

Enhanced Depth Imaging ◽

Depth Imaging ◽

Single Visit ◽

Imaging Optical Coherence Tomography ◽

The Mean ◽

Spectralis Oct ◽

Thickness Measurements ◽

Lens Wear ◽

Manual Correction

ObjectiveTo investigate the repeatability of choroidal thickness measurements determined from enhanced depth imaging optical coherence tomography (EDI-OCT) images of eyes after wearing single-vision spectacles (SV) and orthokeratology (ortho-k) lenses.Methods and analysisTwo EDI-OCT images of 40 children (SV: 20, ortho-k: 20) taken at a single visit were analysed twice. Subjects in the ortho-k group had been wearing ortho-k for 1–4 weeks. The choroidal thickness was determined from each image using a graph theory-based software and, where appropriate, manual correction of choroidal boundaries was undertaken by an experienced examiner.ResultsThe mean (±SD) choroidal thickness was 227.3±42.2 µm for the SV subjects and 251.1±54.4 µm for the ortho-k subjects. The interimage differences in choroidal thickness were −0.99±3.54 and −1.14±5.03 µm for the SV and ortho-k subjects, respectively, and the limits of agreement were +5.96 to −7.93 and +8.72 to −11.00 µm, respectively.ConclusionThe coefficients of repeatability of choroidal thickness measurements from two EDI-OCT images taken at a single visit were 7.08 µm (SV) and 10.06 µm (ortho-k), suggesting that a change in choroidal thickness of less than 10 µm may not indicate a real change resulting from ortho-k lens wear.

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Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study

Angiology ◽

10.1177/0003319717737223 ◽

2017 ◽

Vol 69 (7) ◽

pp. 574-581 ◽

Cited By ~ 7

Author(s):

Fabien Lareyre ◽

Elisabeth Nguyen ◽

Juliette Raffort ◽

Joseph Carboni ◽

Jérôme Doyen ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Carotid Endarterectomy ◽

Carotid Stenosis ◽

Choroidal Thickness ◽

Enhanced Depth Imaging ◽

Optical Coherence ◽

Depth Imaging ◽

Imaging Optical Coherence Tomography ◽

The Mean ◽

Contralateral Eye

The influence of both severe chronic carotid stenosis and carotid endarterectomy (CEA) on ocular tissue has been poorly evaluated. The goal of this study was to measure subfoveal choroidal thickness (SFCT), before and after CEA, in patients with severe carotid stenosis. Consecutive patients (n = 36) with severe carotid stenosis were prospectively included. Patients (n = 19) were followed up at 1 and 3 months after CEA. The SFCT was measured bilaterally using enhanced depth imaging optical coherence tomography (EDI-OCT). Preoperatively, the median SFCT of the ipsilateral eye did not differ significantly from the contralateral eye (223 vs 236 µm; P = .75). In the ipsilateral eye, the mean SFCT was significantly higher at 1 month postsurgery and the effect was maintained at 3 months (226.3 ± 17.1 at 3 months vs 210.8 ± 16.5 µm at baseline; P < .001). For the contralateral eye, the increase in SFCT reached statistical significance at 3 months (220.1 ± 11.3 at 3 months vs 214.8 ± 11.5 µm at baseline; P = .04). The mean SFCT significantly increased bilaterally after CEA, with a more noticeable effect in the ipsilateral eye. Further studies are required to determine whether EDI-OCT could be useful as a potential marker of ophthalmologic outcomes.

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