scholarly journals Comparison of the Postoperative Effects of Local Antibiotic versus Systemic Antibiotic with the Use of Platelet-Rich Fibrin on Impacted Mandibular Third Molar Surgery: A Randomized Split-Mouth Study

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Ceren Melahat Donmezer ◽  
Kani Bilginaylar
Keyword(s):  
Third Molar ◽  
Third Molar Surgery ◽  
Control Group ◽  
Platelet Rich Fibrin ◽  
Systemic Antibiotic ◽  
Group 4 ◽  
Mandibular Third Molar ◽  
Mandibular Third Molar Surgery ◽  
Systemic Antibiotics ◽  
Local Antibiotic

The surgery of the impacted mandibular third molar is the most frequent procedure in dentistry. The prescription of systemic antibiotics after the third molar extraction is widespread among dentists, but this is still argumentative. This study is aimed at evaluating the postoperative effects of local antibiotic mixed with platelet-rich fibrin (PRF) and a postoperative systemic antibiotic prescribed for mandibular third molar surgery. The study included 75 patients divided into a control and 4 test groups ( n = 15 ). In the control group, only PRF was placed into the extracted socket, and no antibiotic was prescribed. In the first and third groups, PRF was applied to the socket; penicillin and clindamycin were prescribed as oral medications, respectively. In the second and fourth groups, only PRF combined with penicillin and clindamycin was applied into the socket, respectively. The outcome variables were pain, swelling, analgesic intake, and trismus. These variables were also assessed based on the first, second, third, and seventh days following the operation. Unpaired Student’s t -test and Mann–Whitney U test were used for analysis. There were significant differences in the total VAS pain scores between the control and group 3 ( p < 0.05 ), groups 1 and 2 ( p < 0.01 ), and group 4 ( p < 0.001 ) in ascending order. For analgesic intake, there was no significant difference for group 1 ( p > 0.05 ). However, there were statistical differences between the control group and groups 2 and 3 ( p < 0.01 ) and group 4 ( p < 0.001 ). Trismus and swelling did not differ among the groups ( p > 0.05 ). This study showed that the effects of local and systemic antibiotics with the use of PRF reduced postoperative outcomes. Moreover, local antibiotics with PRF may be a viable method to avoid the possible side effects of systemic antibiotics.

scholarly journals Role of Dexamethasone in reducing Postoperative Sequelae following Impacted Mandibular Third Molar Surgery: A Comparative Clinical Study

2017 ◽  
Vol 8 (2) ◽  
pp. 53-60 ◽  
Author(s):  
Bipin C Reddy ◽  
Mueedul Islam ◽  
Azhar Khan ◽  
Shoaib N Parkar ◽  
Tanmoy Nath ◽  
...  
Keyword(s):  
Clinical Study ◽  
Third Molar ◽  
Third Molar Surgery ◽  
Control Group ◽  
Dexamethasone Group ◽  
Impacted Mandibular Third Molar ◽  
Mandibular Third Molar ◽  
Comparative Clinical Study ◽  
Mandibular Third Molar Surgery

ABSTRACT Aims and objectives To understand the benefits of dexamethasone and compare the effects of submucosal vs intramuscular (IM) administration of dexamethasone in reducing postoperative sequelae following impacted mandibular third molar surgery. Materials and methods The study was conducted on 90 patients, who were divided into three groups of 30 each. The two experimental groups were given dexamethasone 4 mg submucosally or intramuscularly (preoperatively), and the control group did not receive any form of corticosteroid. Measurements of facial swelling and maximal interincisal distance were made preoperatively and on the 1st, 3rd, and 7th postoperative days. Pain was evaluated from patients' response to visual analog scale and recording the number of rescue analgesic tablets taken at the end of the 7th postoperative day. Results Both dexamethasone groups showed a significant reduction in pain, swelling, and trismus as compared with the control group at all intervals. There was a statistically significant reduction in magnitude of swelling in the submucosal dexamethasone group as compared with the IM dexamethasone group on the 1st postoperative day, but there was no significant difference among two experimental groups at other times and their effects were comparable for all variables. Conclusion Dexamethasone 4 mg is an effective therapeutic strategy for reducing postoperative sequelae following surgical removal of impacted third molars and submucosal dexamethasone is an effective alternative to dexamethasone given systemically. How to cite this article Imran M, Reddy BC, Islam M, Khan A, Parkar SN, Nath T. Role of Dexamethasone in reducing Postoperative Sequelae following Impacted Mandibular Third Molar Surgery: A Comparative Clinical Study. J Health Sci Res 2017;8(2):53-60.

scholarly journals A comparative analysis of the efficacy of moxifloxacin and cefixime in reduction postoperative inflammatory sequelae after mandibular third molar surgery

2020 ◽  
pp. 122-122
Author(s):  
Branimir Stosic ◽  
Ivan Sarcev ◽  
Sinisa Mirkovic ◽  
Branislav Bajkin ◽  
Ivan Soldatovic
Keyword(s):  
Scientific Evidence ◽  
Third Molar ◽  
Study Groups ◽  
Third Molar Surgery ◽  
Control Group ◽  
Double Blind Study ◽  
Double Blind ◽  
Dry Socket ◽  
Mandibular Third Molar ◽  
Mandibular Third Molar Surgery

Background/Aim. There is no scientific evidence that prophylactic use of antibiotics as a part of the mandibular third molar surgery is effective in suppressing postoperative pain, edema, trismus and dry socket. The aim of the present study was to investigate the effects of antibiotics from the fluoroquinolone (moxifloxacin) and cephalosporin (cefixime) groups, in reducing inflammatory postoperative sequelae (pain, edema and trismus), as well as in possibly reducing the incidence of dry socket after mandibular third molar surgery. Methods. This double-blind study was completed by 157 subjects, comprising two study groups (who received the aforementioned antibiotics), and a control group, who received placebo-tablets. Subjects were assessed on the first, second, and seventh day following surgery. In the postoperative course, patients were monitored for the occurrence, intensity and duration of postoperative inflammatory sequelae and dry socket. Results. Both antibiotics, especially moxifloxacin, had a pronounced effect on reducing all inflammatory sequelae (pain, edema and trismus) as the most common postoperative complaints following mandibular third molar surgery. It is interesting, however, that both antibiotics, especially moxifloxacin, also contributed to reducing the incidence of dry socket. Conclusion. Antibiotic prophylaxis with cefixime, and especially moxifloxacin, reduced the occurrence of postoperative inflammatory sequelae and alleviated discomfort, suggesting that this is a useful, rather than risky recommendation. It is interesting, however, that both antibiotics, especially moxifloxacin, also contributed inreducing the incidence of postoperative dry socket, which is not provoked by inflammation. Therefore, further research into the underlying mechanisms behind such an effect is warranted.

Sign in / Sign up

Export Citation Format

Share Document