scholarly journals Henoch–Schönlein Purpura Associated with Lung Cancer: When Paraneoplastic Manifestations Impede Oncological Management

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Éloïse Philippe ◽  
Aude Barnier ◽  
Juliette Menguy ◽  
Gilles Robinet ◽  
Gilles Quéré ◽  
...  
Keyword(s):  
Lung Tumor ◽  
Locally Advanced ◽  
Lung Squamous Cell Carcinoma ◽  
Henoch Schonlein Purpura ◽  
Systemic Corticosteroids ◽  
Programmed Death ◽  
Programmed Death Protein 1 ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background. Henoch–Schönlein purpura (HSP) is an uncommon syndrome that mostly occurs in children, in whom it is frequently triggered by infections. In contrast, HSP in adults is more frequently of neoplastic origin. Case Presentation. We report HSP associated with a locally advanced lung squamous cell carcinoma that was considered a paraneoplastic syndrome. Systemic corticosteroids were given because a kidney biopsy revealed active glomerulonephritis. Concomitant chemoradiotherapy achieved a partial response of the lung tumor. Consolidation immunotherapy (programmed death protein-1-ligand-1 (PD-L1) inhibitor) was cancelled because HSP is known to be an autoimmune vasculitis, and long-term corticosteroid therapy was pursued. Conclusion. Further prospective studies are needed to evaluate the effect of anti-PD-(L) 1 immunotherapies on autoimmune manifestations.

scholarly journals Renal transplantation in adults with Henoch-Schonlein purpura: long-term outcome

2008 ◽  
Vol 23 (9) ◽  
pp. 3010-3016 ◽  
Author(s):  
G. Moroni ◽  
B. Gallelli ◽  
A. Diana ◽  
A. Carminati ◽  
G. Banfi ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Henoch Schonlein Purpura ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Outcome of Henoch-Schönlein purpura nephritis treated with long-term immunosuppression

2007 ◽  
Vol 22 (10) ◽  
pp. 1717-1722 ◽  
Author(s):  
Mohan Shenoy ◽  
Mark G. Bradbury ◽  
Malcolm A. Lewis ◽  
Nicholas J. A. Webb
Keyword(s):  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Purpura Nephritis

scholarly journals SEVERE GASTROINTESTINAL MANIFESTATIONS COMPLICATING HENOCH-SCHÖNLEIN PURPURA IN ADULT: A RARE CASE IN INDONESIA

2018 ◽  
Vol 11 (11) ◽  
pp. 11
Author(s):  
William Ray Cassidy ◽  
Ketut Suryana ◽  
Dewi Catur Wulandari
Keyword(s):  
Systemic Vasculitis ◽  
Renal Involvement ◽  
Immunoglobulin A ◽  
Henoch Schonlein Purpura ◽  
Gastrointestinal Manifestations ◽  
Patient Morbidity ◽  
Schonlein Purpura ◽  
Term Monitoring ◽  
Henoch Schönlein Purpura

Henoch-Schönlein purpura (HSP), also known as immunoglobulin A vasculitis, is a self-limiting, small vessel systemic vasculitis rarely found in adults characterized by palpable purpura, arthritis or arthralgia, gastrointestinal, and renal involvement. We report a case of a 31-year-old male with HSP complicated with severe gastrointestinal manifestations mimicking acute abdomen. He was successfully managed with conservative approach. Meticulous diagnosis, treatment, and long-term monitoring are important to reduce patient morbidity.

P064 Henoch-Schonlein Purpura: experience of a general pediatric center

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_5) ◽  
Author(s):  
D J Belamri ◽  
I Boustil ◽  
S Zoubir ◽  
Bensoltane H Chériet ◽  
N Bouchair
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Involvement ◽  
Winter Period ◽  
Henoch Schonlein Purpura ◽  
Severe Renal Failure ◽  
Benign Condition ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Abstract Background Henoch-Schonlein purpura (HSP) is the most classic dysimmune vasculitis in children, related to an abnormal response of an immature immune system following an external antigen attack. Digestive involvement in HSP conditions the immediate vital prognosis and severe renal failure conditions the long-term functional prognosis. The Objective is to identify the epidemiological, clinical, disease course and therapeutic particularities of patients with HSP with a review of the literature. Material and method The authors reported the results of a retrospective study of cases of patients with HSP hospitalized and treated in the 02 pediatric departments of the wilaya of Annaba in Algeria (Clinique Sainte Thérèse, Annaba hospital university center and EHS El Bouni) over a period of 02 years. Information was obtained from hospital records. Results 24 cases of HSP were identified with a sex ratio of 1.4 (14 boys and 10 girls) and a hospital incidence of 1.66%. The average age was 6.6 years. Half of patients was hospitalized during the autumn-winter period, 67% of whom had an ENT infection before their hospitalizations. 17% of cases have personal history of HSP (the oldest was 5 years ago and the most recent 10 days before hospitalization). 7 patients underwent surgeries prior to hospitalization. Skin lesions were found in all patients. Joint, digestive and renal involvement were recorded in 50%, 80% and 25% respectively. Gastrointestinal bleeding has been observed in one patient. Only 1 patient with renal impairment progressed to chronic renal failure and only 1 patient had confirmed hypertension. A rare association with viral hepatitis A has been noted in one patient. Conclusion HSP remains a benign condition, easy to recognize clinically. Its immediate prognosis depends on the digestive complications and its long-term on nephropathy which may expose to the risk of chronic renal failure.

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